Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Early phase 1Not yet taking people in United States
PICSTAT Pilot Study for CD8 PET/CT-Guided Lifileucel Treatment in Advanced Melanoma
Where
Philadelphia
Age
18 years and over
People
10
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT07700121
Phase 1/2Taking people
A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)
Where
Aurora, Boston, Chicago, Dallas, Fargo, New York, Sioux Falls
Age
6 months to 17 years
People
370 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT02332668 · EU 2022-501257-36-00
No phaseTaking people
Navigation Intervention for Adolescent and Young Adult Cancer Survivors
Where
Pasadena
Age
21 years to 45 years
People
25
Run by
Kaiser Permanente
See details and how to joinNCT07406087
No phaseNot yet taking people in United States
A Disposable Negative Pressure Wound Therapy Device (SNaP) to Promote Wound Healing in the Lower Limbs Following Mohs Micrographic Surgery for Non-melanoma Skin Cancer
Where
Los Angeles
Age
19 years to 79 years
People
60
Run by
Jonsson Comprehensive Cancer Center
See details and how to joinNCT07032701
Phase 3Taking people
Adjuvant Tebentafusp in High Risk Ocular Melanoma
Where
Lake Success
Age
18 years and over
People
290 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT06246149 · EU 2023-510333-28-00
No phaseTaking people
Integrated Cancer Repository for Cancer Research
Where
Aitkin, Alliance, Aurora, Bozeman, Brainerd, Canton, Council Bluffs, Daytona Beach, DeLand, Duluth, Fargo, Fayetteville, Fergus Falls, Fort Wayne, Glens Falls, Green Bay, Greenwood Village, Hastings, Holyoke, Kansas City, Liberty, Manchester, Minot, Norfolk, North Kansas City, North Platte, Omaha, Orange City, Overland Park, Palm Coast, Randallstown, Saint Joseph, Tallahassee, Utica, Waterloo, Westminster, Yorkville
Age
19 years to 110 years
People
999,999
Run by
University of Nebraska
See details and how to joinNCT02012699
No phaseTaking people
The Multicentre Selective Lymphadenectomy Trial - 3
Where
Los Angeles
Age
18 years and over
People
1,500 worldwide
Run by
Melanoma Institute Australia
See details and how to joinNCT07049276
No phaseTaking people
Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)
Where
Forth Worth, Fort Smith, Frederick, Oklahoma City, Springfield, St Louis, Temple
Age
18 years and over
People
2,000
Run by
Elephas
See details and how to joinNCT07327489
Phase 1/2Taking people
Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma
Where
Tampa
Age
18 years and over
People
36
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT06961357
No phaseTaking people
Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study
Where
Columbus
Age
18 years and over
People
70
Run by
Ohio State University Comprehensive Cancer Center
See details and how to joinNCT07215988
Phase 2Taking people
Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
Where
Pittsburgh
Age
18 years and over
People
72
Run by
Dan Zandberg
See details and how to joinNCT04114136
No phaseTaking people
Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients
Where
Rochester
Age
18 years and over
People
350
Run by
Mayo Clinic
See details and how to joinNCT07379138
No phaseNot yet taking people in United States
Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor
Where
Portland
Age
18 years and over
People
50
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT07660666
No phaseTaking people
Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types
Where
Rochester
Age
18 years and over
People
500
Run by
Mayo Clinic
See details and how to joinNCT06075524
No phaseTaking people
Immediate Lymphatic Reconstruction After Lymphadenectomy in Melanoma Patients: a Parallel Cohort Pilot Study
Where
Houston
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06887205
Phase 2Taking people
Adjuvant Quisinostat in High-Risk Uveal Melanoma
Where
Miami
Age
19 years and over
People
63
Run by
University of Miami
See details and how to joinNCT06932757
No phaseTaking people
In Vivo Real-time Detection of Circulating Melanoma Cells
Where
Little Rock
Age
18 years to 80 years
People
75
Run by
University of Arkansas
See details and how to joinNCT01776905
No phaseTaking people
Familial Investigations of Childhood Cancer Predisposition
Where
Memphis
People
1,500
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT03050268
No phaseNot yet taking people in United States
Evaluating a Decision Aid for Sentinel Lymph Node Biopsy in Intermediate-Risk Melanoma
Where
Charlottesville
Age
18 years and over
People
66
Run by
University of Virginia
See details and how to joinNCT07653087
Phase 1Taking people
AB821 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Where
New Haven
Age
18 years and over
People
50
Run by
Yale University
See details and how to joinNCT07027488
Phase 1/2Taking people
A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel
Where
Chapel Hill, Denver, Nashville
Age
18 years to 70 years
People
42 worldwide
Run by
Iovance Biotherapeutics, Inc.
See details and how to joinNCT06940739
Phase 2Taking people
Neoadjuvant Tebentafusp for Uveal Melanoma
Where
Philadelphia
Age
18 years and over
People
19
Run by
Thomas Jefferson University
See details and how to joinNCT06414590
No phaseTaking people
Evolution of Metabolic and Immune Dysfunction in In-transit Melanoma
Where
Pittsburgh
Age
18 years and over
People
20
Run by
Yana Najjar
See details and how to joinNCT04658303
Phase 2Taking people
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
Where
Houston
Age
18 years and over
People
50
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04771520
Phase 1Taking people
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
Where
Durham, Tampa
Age
18 years and over
People
40
Run by
Memgen, Inc.
See details and how to joinNCT05076760