Multiple sclerosis trials in France

In France 70 Also abroad 503

70 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
MAESTRO-4MS : "Allogenic Adipose tissue-derived Mesenchymal Stromal Cells for the treatment of Primary Progressive Multiple Sclerosis: an open-label phase I clinical trial."
Where
Creteil, Rennes
Age
18 years to 64 years
People
15
Run by
Centre Hospitalier Universitaire De Rennes
See details and how to join2023-509538-20-01 · EU 2023-509538-20-01
Phase 3Taking people
A Prospective Randomized Non-inferiority Trial Comparing Anti-CD20 Maintenance Versus De-Escalation Strategy In Relapsing-Remitting Multiple Sclerosis
Where
Ajaccio, Bayonne, Besancon Cedex, Bordeaux, Caen Cedex 9, Clermont Ferrand Cedex 1, Creteil, Dijon, La Tronche, Libourne Cedex, Lille Cedex, Marseille, Montpellier Cedex 5, Nancy, Nantes Cedex 1, Nice, Nîmes, Pau Cedex, Poissy, Rennes, Rouen Cedex, Strasbourg Cedex 2, Suresnes, Toulouse, Tours
Age
40 years and over
People
250
Run by
University Hospital, Montpellier
See details and how to joinNCT07189325 · EU 2024-513292-40-00
No phaseTaking people
Diagnostic Value of eVOG
Where
Nice
Age
18 years and over
People
150
Run by
Centre Hospitalier Universitaire de Nice
See details and how to joinNCT05776511
No phaseNot yet taking people in France
PRIMUS : Real World Usage for Real World Evidence of CDSS Use in Multiple Sclerosis
Where
Angers, Antibes, Bordeaux, Brest, Caen, Clermont-Ferrand, Colmar, Créteil, Dijon, Épinal, Grenoble, La Roche-sur-Yon, Lille, Lyon, Marseille, Metz, Montpellier, Nancy, Nice, Nîmes, Paris, Poissy, Poitiers, Rennes, Rouen, Saint-Brieuc, St-Malo, Strasbourg, Toulouse, Tours, Vannes
Age
18 years to 50 years
People
448
Run by
Nantes University Hospital
See details and how to joinNCT07647952
No phaseNot yet taking people in France
Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
Where
Strasbourg
Age
18 years and over
People
200
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT07560995
No phaseTaking people
Deployment o the Multidisciplinary Prospective Cohort Imminent
Where
Lille
Age
18 years and over
People
2,200
Run by
University Hospital, Lille
See details and how to joinNCT04334031
No phaseTaking people
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
Where
Poitiers
Age
18 years and over
People
50
Run by
Poitiers University Hospital
See details and how to joinNCT05491031
No phaseNot yet taking people in France
Multicenter Prospective Study Analyzing the Occurrence of Multiple Sclerosis Relapses Without Radiological Evidence: Myth or Reality?
Where
Colmar, Dijon, Haguenau, Metz, Mulhouse, Nancy, Reims, Strasbourg
Age
18 years to 70 years
People
136
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT07545889
No phaseTaking people
How to Develop the Highest Possible Leading-edge Interdisciplinary Care Model for People With MS, That Will be Relevant to All Stakeholders and Declinable to Different Local Contexts With the Ultimate Goal of Ensuring the Highest Level of Quality of Care in MS.
Where
Paris
Age
18 years and over
People
57
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT07289724
Phase 3Taking people
For patients with active multiple sclerosis, impact of annual versus semi-annual infusions of ocrelizumab after 2 years of initial treatment on the absence of radiological disease activity at 2 years: a multicentre randomised controlled non-inferiority trial
Where
Bron, Creteil Cedex, Gonesse, Grenoble Cedex 09, Limoges Cedex 1, Nice, Paris, Paris Cedex 13, Poissy, Strasbourg Cedex 2, Suresnes
Age
18 years and over
People
244
Run by
Hopital Fondation Adolphe De Rothschild
See details and how to join2023-505420-62-00 · EU 2023-505420-62-00
No phaseTaking people
EXOPULSE Suit and Walking Ability of Patients With Multiple Sclerosis
Where
Berck, Créteil, Dijon, Gaillac-Toulza, Garches, Lomme, Lyon, Nice, Rennes, Saint-Genis-Laval, Strasbourg
Age
18 years and over
People
77
Run by
Otto Bock France SNC
See details and how to joinNCT07252895
No phaseTaking people
Comparison of the Performance of the 2024 and 2017 McDonald Criteria for the Diagnosis of Multiple Sclerosis in Real Life
Where
Ars-Laquenexy, Nancy
People
100
Run by
Central Hospital, Nancy, France
See details and how to joinNCT07492667
No phaseTaking people
Investigating Specific Gait Patterns in Individuals Living With Multiple Sclerosis
Where
Lille
Age
18 years to 65 years
People
30
Run by
SYSNAV
See details and how to joinNCT07388992
No phaseTaking people
From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis
Where
Nantes
Age
18 years and over
People
130
Run by
Nantes University Hospital
See details and how to joinNCT04873492
No phaseTaking people
Common and Specific Information From Neuroimaging and Smartphone
Where
Nantes
Age
18 years and over
People
100
Run by
Nantes University Hospital
See details and how to joinNCT05482906
No phaseTaking people
Exploring Cortical Remyelination in Children With Multiple Sclerosis
Where
Le Kremlin-Bicêtre, Paris
Age
12 years to 18 years
People
40
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT05258396
Phase 2/3Taking people
Study of Neuroinflammation in Multiple Sclerosis by PET-MRI Imaging Using the Radiotracer ([18F]-DPA-714) : a Multicentre Cohort Study (INFLANET)
Where
Bron, Orsay Cedex, Paris Cedex 13, Rennes, Rennes Cedex, Toulouse, Vandoeuvre Les Nancy
Age
18 years to 64 years
People
41
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06280742 · EU 2023-510304-53-00
No phaseTaking people
Clinical and Urodynamic Assessment of Bladder Sensation in Multiple Sclerosis
Where
Paris
Age
18 years to 99 years
People
113
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT05772637
Phase 3Taking people
RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis.
Where
Brest Cedex 2, Bron Cedex, Caen Cedex 9, Clermont-Ferrand, Creteil Cedex, Gonesse, Grenoble Cedex 9, Limoges, Lomme Cedex, Marseille, Montpellier Cedex 5, Nancy, Nice, Nimes Cedex 9, Paris, Poissy, Poitiers, Pontoise, Quimper Cedex, Rennes, Rouen Cedex, Saint-Herblain, Saint-Malo Cedex, Strasbourg Cedex, Suresnes, Toulouse
Age
18 years to 55 years
People
386
Run by
Rennes University Hospital
See details and how to joinNCT05758831 · EU 2022-501027-25-01
No phaseTaking people
Comparison of Digital Biomarkers in Subjects With Radiologically Isolated Syndrome (RIS) and Multiple Sclerosis (MS) Patients With Clinically Normal Neurological Examination
Where
Nice
Age
18 years to 60 years
People
150
Run by
Centre Hospitalier Universitaire de Nice
See details and how to joinNCT07135752
No phaseTaking people
French Registry for Monitoring Pregnancies for Multiple Sclerosis
Where
Amiens, Annecy, Avignon, Besançon, Bordeaux, Brive-la-Gaillarde, Bron, Caen, Chambéry, Clermont-Ferrand, Créteil, Dijon, Épinal, Garches, Gonesse, Grenoble, Le Chesnay, Lille, Limoges, Lyon, Marseille, Montpellier, Mornant, Nancy, Nice, Nîmes, Paris, Poissy, Poitiers, Pontoise, Rennes, Rouen, Saint-Denis, Saint-Herblain, Saint-Lô, Saint-Priest-en-Jarez, Strasbourg, Suresnes, Toulouse, Tours, Villeurbanne
People
1,500 worldwide
Run by
Hospices Civils de Lyon
See details and how to joinNCT03900221
No phaseTaking people
Evaluation of New MRI Sequences Including 3D-FGAPSIR for the Optimization of Inflammatory Spinal Cord Lesions Research
Where
Paris
Age
18 years and over
People
200
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT04906928
No phaseTaking people
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
Where
Paris
Age
18 years and over
People
196
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT06589999
Phase 1Taking people
Allogenic Adipose Tissue-derived Mesenchymal Stromal Cells for the Treatment of Primary Progressive Multiple Sclerosis
Where
Créteil, Rennes
Age
18 years to 55 years
People
10
Run by
Rennes University Hospital
See details and how to joinNCT06592703
No phaseTaking people
Escalation vs. Induction Therapy Strategy in Patients With Early-Onset MS After Age 50
Where
Strasbourg
Age
50 years and over
People
830
Run by
University Hospital, Strasbourg, France
See details and how to joinNCT07313462