Smoking and nicotine dependence trials in United States

In United States 164 Also abroad 266

164 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Testing the mHealth App Intervention for Nondaily Smokers "SiS4"
Where
Boston
Age
18 years and over
People
1,600
Run by
Massachusetts General Hospital
See details and how to joinNCT06678243
No phaseTaking people
Generalized and Domain-Specific Episodic Thinking for Smoking Cessation
Where
Roanoke
Age
21 years and over
People
134
Run by
Virginia Polytechnic Institute and State University
See details and how to joinNCT07158749
No phaseTaking people
Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke
Where
Boston
Age
18 years and over
People
100
Run by
Massachusetts General Hospital
See details and how to joinNCT06654414
Phase 4Taking people
Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial
Where
Houston
Age
18 years and over
People
2,010
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04604509
Phase 4Taking people
The Avenues Study: Dual Use Cessation
Where
Madison
Age
21 years and over
People
500
Run by
University of Wisconsin, Madison
See details and how to joinNCT06474299
No phaseTaking people
Smoking Cessation CM for Veterans With or at Risk for Cancer
Where
San Francisco
Age
18 years and over
People
108
Run by
VA Office of Research and Development
See details and how to joinNCT06432985
Phase 2Taking people
Smoking Cessation Pharmacotherapy-Nurse Practitioner Led Tobacco Treatment Team Study
Where
Springfield
Age
18 years and over
People
424
Run by
Baystate Medical Center
See details and how to joinNCT05733767
No phaseNot yet taking people in United States
LLM Intervention for Tobacco in Underserved Populations (LIFT-UP)
Where
Salt Lake City
Age
18 years and over
People
22
Run by
University of Utah
See details and how to joinNCT07620301
No phaseTaking people
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
Where
Winston-Salem
Age
18 years and over
People
314
Run by
Wake Forest University Health Sciences
See details and how to joinNCT06883097
No phaseTaking people
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
Where
West Haven
Age
18 years and over
People
220
Run by
VA Office of Research and Development
See details and how to joinNCT06442514
Phase 2/3Taking people
A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation
Where
Rochester
Age
18 years and over
People
150
Run by
Mayo Clinic
See details and how to joinNCT07487818
No phaseNot yet taking people in United States
Smartphone-based Incentives Intervention to Increase Smoking Cessation During Pregnancy
Where
Burlington
Age
18 years to 50 years
People
137
Run by
University of Vermont
See details and how to joinNCT07840118
Phase 4Not yet taking people in United States
Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial
Where
Bridgeport, Brooklyn, Jersey City, New Haven, Paterson
Age
18 years and over
People
794
Run by
Yale University
See details and how to joinNCT07835555
Phase 2Taking people
Semaglutide for Post-Smoking Cessation Weight Management
Where
Austin, Houston
Age
18 years to 75 years
People
197
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT06173778
No phaseTaking people
Actívatexto: Advancing Smoking Cessation and Physical Activity Among Latinos
Where
Rochester
Age
18 years and over
People
408
Run by
University of Rochester
See details and how to joinNCT06926608
No phaseEnrolling by invitation
Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment
Where
St Louis
Age
18 years and over
People
915
Run by
Washington University School of Medicine
See details and how to joinNCT05627674
No phaseTaking people
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Where
Houston
Age
22 years to 65 years
People
50
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT05276050
Phase 4Taking people
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
Where
Boston
Age
18 years to 65 years
People
30
Run by
Massachusetts General Hospital
See details and how to joinNCT07145866
No phaseNot yet taking people in United States
Libre Del Cigarrillo: Development of an mHealth Smoking Cessation App to Extend Reach of a Validated Smoking Cessation Intervention for Spanish-speaking Smokers
Where
Tampa
Age
18 years and over
People
120
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT07754448
No phaseTaking people
Orexin s Role in the Neurobiology of Substance Use Disorder
Where
Baltimore
Age
18 years to 60 years
People
140
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT05630781
No phaseTaking people
Temporal Interference Methods for Addiction Treatment
Where
Bloomington, Indianapolis
Age
21 years to 50 years
People
120
Run by
Indiana University
See details and how to joinNCT07210268
No phaseTaking people
Trauma-Informed Care for Smoking Cessation for Pregnancy
Where
San Francisco
Age
18 years and over
People
20
Run by
University of California, San Francisco
See details and how to joinNCT07129590
No phaseTaking people
Modulating Neural Mechanisms of Reward Processing in Tobacco Users
Where
Newark
Age
18 years to 60 years
People
54
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT07812753
Phase 1/2Taking people
Overcoming Nicotine Dependence to Enable Quitting
Where
Chicago
Age
18 years and over
People
780
Run by
Rush University Medical Center
See details and how to joinNCT05513872
Phase 1Not yet taking people in United States
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Where
Charleston
Age
18 years to 65 years
People
20
Run by
Medical University of South Carolina
See details and how to joinNCT07224087