Smoking and nicotine dependence trials in United States

In United States 164 Also abroad 269

164 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users
Where
Seattle
Age
18 years to 30 years
People
1,178
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06909500
No phaseTaking people
Vaped Phenanthrene
Where
Minneapolis
Age
21 years and over
People
100
Run by
University of Minnesota
See details and how to joinNCT07134426
No phaseTaking people
Sex Differences in E-Cigarette Perception
Where
New Haven
Age
21 years to 44 years
People
60
Run by
Yale University
See details and how to joinNCT07398976
Phase 4Taking people
Varenicline for Smoking Reduction in Veterans Not Ready To Quit
Where
Durham, Madison, Minneapolis, San Diego
Age
21 years and over
People
400
Run by
VA Office of Research and Development
See details and how to joinNCT06966362
No phaseTaking people
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
10
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06693700
No phaseEnrolling by invitation
Health Communications for Adults Smoking Nondaily
Where
Lexington
Age
18 years and over
People
320
Run by
Bethany Shorey Fennell, PhD
See details and how to joinNCT07296848
No phaseNot yet taking people in United States
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder
Where
Pittsburgh
Age
22 years to 70 years
People
12
Run by
Payel Roy
See details and how to joinNCT07770555
No phaseNot yet taking people in United States
Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking
Where
Boston
Age
18 years to 75 years
People
937
Run by
Massachusetts General Hospital
See details and how to joinNCT07789132
No phaseTaking people
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Where
Charleston
Age
21 years and over
People
50
Run by
Medical University of South Carolina
See details and how to joinNCT06678789
No phaseTaking people
Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study
Where
Columbus, Houston, La Jolla, New York, Philadelphia, Seattle, St Louis, Tampa, The Bronx, Washington D.C.
Age
45 years to 80 years
People
100
Run by
AIDS Malignancy Consortium
See details and how to joinNCT04949464
No phaseTaking people
A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial
Where
Seattle
Age
18 years and over
People
776
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06145763
No phaseEnrolling by invitation
A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research
Where
Philadelphia
People
500
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT05852860
No phaseTaking people
Evaluating the Impact of CONNECT in a Multilingual Population
Where
San Francisco
Age
50 years to 80 years
People
439
Run by
University of California, San Francisco
See details and how to joinNCT07111936
No phaseTaking people
A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse
Where
Charleston
Age
21 years and over
People
544
Run by
Medical University of South Carolina
See details and how to joinNCT06118502
No phaseNot yet taking people in United States
A Behavioral Application for Improving Smoking Cessation Among Smokers
Where
Seattle
Age
18 years and over
People
1,812
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07493252
No phaseTaking people
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
Where
San Francisco
Age
18 years and over
People
36
Run by
University of California, San Francisco
See details and how to joinNCT06678672
No phaseTaking people
Family-Based Financial Incentives Intervention for Smoking Cessation
Where
Anchorage
Age
18 years and over
People
1,312
Run by
Mayo Clinic
See details and how to joinNCT06556433
Phase 1Taking people
Effects of Cannabidiol on Stress and Nicotine Withdrawal
Where
Baltimore
Age
21 years to 70 years
People
90
Run by
Johns Hopkins University
See details and how to joinNCT07001930
No phaseTaking people
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
Where
Philadelphia
Age
18 years and over
People
3,200
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT06582693
No phaseNot yet taking people in United States
AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation
Where
Buffalo
Age
14 years to 20 years
People
100
Run by
State University of New York at Buffalo
See details and how to joinNCT06965296
No phaseTaking people
Personalized Brain Stimulation to Help Veterans Quit Smoking
Where
Charleston
Age
18 years to 70 years
People
56
Run by
VA Office of Research and Development
See details and how to joinNCT07050862
No phaseTaking people
Maternal Smoking Cessation and Pediatric Obesity Prevention
Where
Buffalo
Age
18 years to 39 years
People
48
Run by
State University of New York at Buffalo
See details and how to joinNCT03514602
No phaseNot yet taking people in United States
Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness
Where
Durham
Age
18 years and over
People
120
Run by
VA Office of Research and Development
See details and how to joinNCT07714200
Phase 3Taking people
Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement
Where
New Brunswick, Salt Lake City
Age
18 years and over
People
420
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT06033599
Phase 2Taking people
Multi-Site Trial of Tirzepatide for Smoking Cessation
Where
Aurora, Chicago, Los Angeles, New Haven
Age
21 years to 65 years
People
300
Run by
University of Southern California
See details and how to joinNCT07602699