Smoking and nicotine dependence trials in United States

In United States 164 Also abroad 269

164 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
Where
Minneapolis
Age
18 years to 45 years
People
171
Run by
University of Minnesota
See details and how to joinNCT04783857
Phase 2Taking people
Enhancing Smoking Cessation for African American People Everywhere
Where
Oklahoma City
Age
18 years and over
People
300
Run by
University of Houston
See details and how to joinNCT07024992
No phaseTaking people
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Where
Los Angeles
Age
21 years to 55 years
People
45
Run by
University of Southern California
See details and how to joinNCT07698470
No phaseTaking people
Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking
Where
Portland
Age
18 years and over
People
800
Run by
Kaiser Permanente
See details and how to joinNCT07459621
No phaseNot yet taking people in United States
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Where
Charlottesville
Age
18 years and over
People
120
Run by
University of Virginia
See details and how to joinNCT07694492
No phaseTaking people
Abuse Liability and Appeal of Oral Nicotine Products
Where
Los Angeles
Age
21 years to 25 years
People
320
Run by
University of Southern California
See details and how to joinNCT06506162
No phaseNot yet taking people in United States
VergeRx for Smokers Not Ready to Quit
Where
Charlottesville
Age
18 years and over
People
592
Run by
University of Virginia
See details and how to joinNCT07693660
No phaseTaking people
American Indian Smokefree Native RCT
Where
Minneapolis
Age
18 years and over
People
416
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT06544811
Early phase 1Taking people
Smart Olfaction App to Reduce Relapse
Where
Houston
Age
18 years and over
People
132
Run by
University of Houston
See details and how to joinNCT07007195
Phase 1/2Not yet taking people in United States
A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Where
Charleston
Age
18 years to 65 years
People
64
Run by
Medical University of South Carolina
See details and how to joinNCT07398404
No phaseTaking people
Preliminary Effectiveness of Enhanced Text Message + Incentives
Where
Kansas City
Age
18 years and over
People
50
Run by
University of Kansas Medical Center
See details and how to joinNCT07420621
No phaseTaking people
Behavioral Intervention for Youth to Promote Vaping Cessation
Where
Boston
Age
14 years to 19 years
People
400
Run by
Massachusetts General Hospital
See details and how to joinNCT06765291
No phaseTaking people
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
Where
Chicago
Age
18 years to 26 years
People
24
Run by
University of Chicago
See details and how to joinNCT06837220
Phase 2Taking people
Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
Where
Spokane
Age
18 years and over
People
205
Run by
Washington State University
See details and how to joinNCT05181891
No phaseTaking people
Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum
Where
Pittsburgh
Age
18 years and over
People
25
Run by
University of Pittsburgh
See details and how to joinNCT07489443
Phase 2Taking people
5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder
Where
Baltimore, Birmingham, New York
Age
21 years and over
People
66
Run by
Johns Hopkins University
See details and how to joinNCT05452772
No phaseTaking people
Testing the Impact of Smartphone-based Messaging to Support Young Adult Smoking Cessation
Where
Baltimore
Age
18 years to 30 years
People
160
Run by
Johns Hopkins Bloomberg School of Public Health
See details and how to joinNCT05836103
No phaseTaking people
PASCAL Feasibility Study
Where
Minneapolis
Age
21 years and over
People
120
Run by
University of Minnesota
See details and how to joinNCT07301151
No phaseTaking people
Non-Invasive Deep Brain Neuromodulation for Smoking Cessation
Where
Houston
Age
20 years to 60 years
People
100
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07298902
Phase 4Taking people
The Options 2 Study
Where
Madison
Age
21 years and over
People
300
Run by
University of Wisconsin, Madison
See details and how to joinNCT06595459
No phaseTaking people
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
Where
New Haven
Age
18 years and over
People
66
Run by
Yale University
See details and how to joinNCT05932745
No phaseTaking people
Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care
Where
Gainesville
Age
21 years and over
People
1,332
Run by
University of Florida
See details and how to joinNCT05415761
Phase 4Taking people
E-cigarette Cessation in Adults Who Co-use Cannabis
Where
Charleston, Lancaster, Pickens
Age
18 years to 40 years
People
105
Run by
Medical University of South Carolina
See details and how to joinNCT06688539
No phaseTaking people
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
Where
Philadelphia
Age
21 years and over
People
472
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT07199517
No phaseTaking people
Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation
Where
Loma Linda, Moreno Valley
Age
18 years and over
People
105
Run by
Loma Linda University
See details and how to joinNCT06438549