Opioid use disorder trials in United States

In United States 229 Also abroad 254

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Early phase 1Taking people
Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
Where
West Haven
Age
18 years to 70 years
People
34
Run by
Yale University
See details and how to joinNCT07886606
Phase 2Taking people
Ketamine for Opioid Use Disorder
Where
Baltimore
Age
18 years to 65 years
People
50
Run by
University of Maryland, Baltimore
See details and how to joinNCT06943859
No phaseEnrolling by invitation
Impact of Collaborative Care for Pregnant Women With Opioid Use Disorder in Low-Resource Obstetric Settings
Where
Pittsburgh
Age
18 years and over
People
1,350
Run by
University of Pittsburgh
See details and how to joinNCT06956352
Phase 1Taking people
MethaLoad Dose-Finding Study
Where
Philadelphia
Age
18 years and over
People
24
Run by
Ashish P Thakrar, MD MS
See details and how to joinNCT06877858
No phaseTaking people
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes
Where
Worcester
Age
18 years and over
People
100
Run by
University of Massachusetts, Worcester
See details and how to joinNCT07637994
No phaseTaking people
The ENHANCE Project Toolkit
Where
Madison
Age
18 years and over
People
40
Run by
University of Wisconsin, Madison
See details and how to joinNCT07649278
No phaseActive, not recruiting
Expanding Medication-Assisted Therapies in Central Asia
Where
New Haven
Age
18 years and over
People
900 worldwide
Run by
Yale University
See details and how to joinNCT05579470
No phaseNot yet taking people in United States
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study
Where
Boston, Durham, Miami, Pittsburgh
Age
18 years and over
People
400
Run by
Duke University
See details and how to joinNCT07216963
Phase 1Not yet taking people in United States
Cannabis Effects on Opioid Self-Administration
Where
Lexington
Age
18 years to 55 years
People
30
Run by
Shanna Babalonis, PhD
See details and how to joinNCT07668635
Phase 3Not yet taking people in United States
Recovery Management Checkup Scalability and Sustainability Hybrid Experiment
Where
Chicago
Age
18 years and over
People
600
Run by
Chestnut Health Systems
See details and how to joinNCT07873944
No phaseTaking people
Supporting Treatment Access and Recovery in COD
Where
Holyoke, Orange, Springfield, Worcester
Age
18 years and over
People
1,000
Run by
University of Massachusetts, Worcester
See details and how to joinNCT05138614
No phaseTaking people
Cortical rTMS as a Treatment for Depression
Where
Houston
Age
18 years to 64 years
People
50
Run by
Baylor College of Medicine
See details and how to joinNCT05487911
No phaseTaking people
Integrating MOUD in Nonmedical Community Settings (Better Together)
Where
Baltimore, Chicago, Miami, Washington D.C.
Age
16 years and over
People
400
Run by
Howard University
See details and how to joinNCT06416020
Phase 2Taking people
Semaglutide for Helping Opioid Recovery
Where
Boston
Age
18 years and over
People
46
Run by
Brigham and Women's Hospital
See details and how to joinNCT06639464
No phaseTaking people
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
Where
New York
Age
18 years to 60 years
People
240
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07318480
Phase 1/2Not yet taking people in United States
Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder
Where
Basalt
Age
18 years to 65 years
People
60
Run by
Clive Michelsen
See details and how to joinNCT07871877
No phaseTaking people
The Effect of Light Intervention on Recovery in Individuals With Opioid Use Disorder (OUD)
Where
Birmingham
Age
18 years to 60 years
People
105
Run by
University of Alabama at Birmingham
See details and how to joinNCT06832007
No phaseNot yet taking people in United States
MedSMA℞T Mobile ED
Where
Madison, Rockford
Age
12 years and over
People
244
Run by
Olufunmilola Abraham
See details and how to joinNCT06848504
Phase 4Taking people
Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic
Where
New Haven
Age
18 years and over
People
60
Run by
Yale University
See details and how to joinNCT07176351
Phase 1Not yet taking people in United States
Cannabis and Opioid Use Disorder, Study 2
Where
Lexington
Age
18 years to 55 years
People
100
Run by
University of Kentucky
See details and how to joinNCT07661446
No phaseTaking people
Supporting Treatment for Opioids and Recovery Capital (STORC) - R61 Phase
Where
Philadelphia
Age
18 years and over
People
10
Run by
Friends Research Institute, Inc.
See details and how to joinNCT07787039
No phaseEnrolling by invitation
Measurement Based Care in Opioid Treatment Programs
Where
Pittsburgh
Age
18 years and over
People
3,650
Run by
University of Pittsburgh
See details and how to joinNCT06965010
No phaseNot yet taking people in United States
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System
Where
Chicago
Age
16 years and over
People
271,031
Run by
University of Illinois Chicago
See details and how to joinNCT07498322
No phaseTaking people
Peer Recovery Coaching for Tobacco Abstinence in People With Opioid Use Disorder
Where
Boston
Age
18 years and over
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT06965153
No phaseNot yet taking people in United States
Clinician Practice Companion to Address Youth Substance Use
Where
Boston
Age
14 years to 24 years
People
60 worldwide
Run by
Massachusetts General Hospital
See details and how to joinNCT07725289