Opioid use disorder trials in United States

In United States 229 Also abroad 254

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
A Bundled Intervention to End Opioid Overdoses
Where
Birmingham
Age
19 years and over
People
160
Run by
University of Alabama at Birmingham
See details and how to joinNCT07485335
Phase 1Taking people
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
Where
New Haven
Age
25 years to 65 years
People
110
Run by
Yale University
See details and how to joinNCT07800520
Phase 3Taking people
Adjunctive Cannabidiol for Recovery From Opioid Study
Where
New York, Portland
Age
18 years to 65 years
People
450
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06940674
No phaseNot yet taking people in United States
Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment
Where
San Diego, Vista
Age
18 years and over
People
295
Run by
Tools4Patient
See details and how to joinNCT07456930
No phaseTaking people
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
Where
Baton Rouge, Duluth, Grants Pass, Greenville, Los Angeles, Milwaukee, Roswell, Washington D.C.
Age
18 years and over
People
512
Run by
Montefiore Medical Center
See details and how to joinNCT07631598
No phaseTaking people
Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents
Where
Boston
Age
18 years and over
People
100
Run by
Boston Medical Center
See details and how to joinNCT06732596
No phaseNot yet taking people in United States
Measurement-Based Care to Support Buprenorphine-Naloxone Treatment in Outpatient Addiction Clinics
Where
Nashville
Age
18 years and over
People
140
Run by
Vanderbilt University Medical Center
See details and how to joinNCT07839182
No phaseNot yet taking people in United States
Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System
Where
Philadelphia
Age
18 years and over
People
74
Run by
Temple University
See details and how to joinNCT07432555
No phaseTaking people
Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD
Where
Charleston
Age
18 years and over
People
40
Run by
Medical University of South Carolina
See details and how to joinNCT06157840
No phaseTaking people
Sensing Physiological Symptoms of Opioid Withdrawal and Cravings in Patients With Opioid Use Disorder
Where
Center City, Columbus
Age
18 years to 50 years
People
20
Run by
Spark Biomedical, Inc.
See details and how to joinNCT06487533
No phaseEnrolling by invitation
TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization
Where
Cincinnati
Age
18 years and over
People
30
Run by
T. John Winhusen, PhD
See details and how to joinNCT07780097
No phaseNot yet taking people in United States
Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation
Where
Lexington
Age
18 years to 75 years
People
60
Run by
University of Kentucky
See details and how to joinNCT07842601
No phaseTaking people
Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
Where
Aurora
Age
12 years to 89 years
People
200,000
Run by
University of Colorado, Denver
See details and how to joinNCT06526286
Phase 3Taking people
A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)
Where
Baltimore, Bradenton, Charleston, DeSoto, Garden Grove, Houston, Marlton, New Haven, Oklahoma City, Philadelphia, Providence, Richmond, Savannah
Age
18 years to 70 years
People
300
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06655883
No phaseTaking people
A Clinical Trial of Telehealth Treatment for Opioid Use Disorders
Where
New Haven
Age
18 years and over
People
470
Run by
Yale University
See details and how to joinNCT07362082
Phase 1Taking people
Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder
Where
Indianapolis
Age
18 years to 65 years
People
40
Run by
Proniras Corporation
See details and how to joinNCT06538558
No phaseTaking people
Kentucky Women's Justice Community Overdose Innovation Network - Phase II
Where
Barbourville, Harlan, Hyden
Age
18 years and over
People
300
Run by
Michele Staton
See details and how to joinNCT07179614
No phaseTaking people
A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals
Where
Wilmington
Age
22 years and over
People
420
Run by
OpiAID
See details and how to joinNCT07405398
Phase 4Taking people
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
Where
Boston, Denver, Huntington, Minneapolis, Oakland, San Francisco
Age
18 years to 99 years
People
600
Run by
Yale University
See details and how to joinNCT06323824
No phaseTaking people
Real-time Opioid Study
Where
New Haven
Age
18 years to 50 years
People
3
Run by
Yale University
See details and how to joinNCT07768007
Phase 4Taking people
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
Where
Bay Pines, Boston, Cleveland, Dallas, Dayton, Gainesville, Hampton, Huntington, Long Beach, Milwaukee, Minneapolis, Palo Alto, Philadelphia, Phoenix, Pittsburgh, Providence, Salem, Salt Lake City, San Francisco, Seattle, Tuscaloosa, West Haven, White River Junction, Wilmington
Age
18 years and over
People
952
Run by
VA Office of Research and Development
See details and how to joinNCT04375033
Phase 1Taking people
OMAR Opioid Use Disorder
Where
New Haven
Age
18 years and over
People
30
Run by
Yale University
See details and how to joinNCT05683184
No phaseTaking people
Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
Where
Columbus
Age
14 years to 24 years
People
300
Run by
Ohio State University
See details and how to joinNCT06311838
No phaseTaking people
Improving Outcomes for Early Postpartum Mothers in Outpatient MOUD Treatment
Where
Little Rock
Age
18 years and over
People
10
Run by
University of Arkansas
See details and how to joinNCT07071766
No phaseTaking people
Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid Use Disorder in Durham, North Carolina
Where
Durham
Age
18 years and over
People
80
Run by
Duke University
See details and how to joinNCT07810322