Sarcoma trials in United States

In United States 300 Also abroad 605

300 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors
Where
Houston
Age
18 years and over
People
54
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05039801
Phase 1/2Taking people
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
Where
Birmingham, Dallas, Detroit, Gainesville, Hackensack, Hartford, Hershey, Honolulu, Kansas City, Louisville, Miami, Nashville, Oakland, Orlando, Phoenix, Providence, Richmond, Sacramento, Salt Lake City, San Diego, St Louis, St. Petersburg, Tampa
Age
Up to 30 years
People
104 worldwide
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT06541262
Phase 1/2Taking people
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors
Where
Boston, Houston, Los Angeles, Philadelphia, Salt Lake City, San Francisco
Age
1 year to 30 years
People
59
Run by
Theodore Laetsch
See details and how to joinNCT06721689
No phaseTaking people
Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial
Where
Phoenix, Rochester
Age
2 years and over
People
170
Run by
Mayo Clinic
See details and how to joinNCT07188532
Phase 2Taking people
Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma
Where
Hershey, Portland, Tampa
Age
0 years to 50 years
People
406
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT07321912
Phase 1Taking people
A Study of PHST001 in Advanced Solid Tumors
Where
Ann Arbor, Beverly Hills, Boston, Chicago, Denver, Durham, Fairfax, Fort Worth, Grand Rapids, Houston, Irving, Lake Success, Los Angeles, Nashville, New Haven, New York, Palo Alto, San Antonio
Age
18 years and over
People
426
Run by
Pheast Therapeutics
See details and how to joinNCT06840886
Phase 2Taking people
Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients With Advanced Leiomyosarcoma
Where
Columbus
Age
18 years and over
People
16
Run by
Gabriel Tinoco
See details and how to joinNCT06528769
No phaseTaking people
Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing
Where
Bethesda
Age
2 years to 100 years
People
100
Run by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
See details and how to joinNCT06749366
Phase 1/2Taking people
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Where
Dothan, Grand Rapids, Houston, Omaha
Age
18 years and over
People
61
Run by
Radiopharm Theranostics, Ltd
See details and how to joinNCT07189871
Phase 1/2Taking people
A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)
Where
West Valley City
People
64 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07602777
Phase 1Taking people
Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarcoma
Where
Atlanta
Age
Up to 50 years
People
12
Run by
Emory University
See details and how to joinNCT06492954
Phase 3Taking people
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
Where
Bethesda, Boston, Canton, Chicago, Houston, New York, Portland, Rochester
Age
18 years and over
People
16 worldwide
Run by
Rezolute
See details and how to joinNCT06881992
Phase 1Taking people
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
Where
Aurora, Duarte, Houston, New Haven, San Antonio, Sarasota
Age
18 years and over
People
405 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06884618 · EU 2024-519622-20-00
Phase 1/2Taking people
A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
Where
Atlanta, Aurora, Boston, Charlotte, Cleveland, Dallas, Hershey, Houston, Los Angeles, Memphis, New Brunswick, New York, Orlando, Philadelphia, Richmond, Scarborough, St Louis
Age
Up to 25 years
People
75 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT04094610 · EU 2023-506464-14-00
No phaseTaking people
DESTINY-PANTUMOUR04
Where
Birmingham, Boulder, Bullhead City, Canton, Casa Grande, Coral Springs, Dallas, Decatur, Durham, Farmington, Maumee, Nashville, Philadelphia, San Diego, St. Petersburg, Topeka, West Palm Beach, Wilson
Age
18 years to 130 years
People
100
Run by
AstraZeneca
See details and how to joinNCT07124000
Phase 2Taking people
A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)
Where
Houston
Age
18 years and over
People
70
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07193550
Phase 1Taking people
Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes
Where
Atlanta, Birmingham, Buffalo, Chapel Hill, Charlotte, Cleveland, Columbus, Durham, Gainesville, Grand Rapids, Hartford, Jacksonville, Lexington, Miami, Nashville, Phoenix, Salt Lake City, St. Petersburg, Tampa, The Bronx
Age
1 year and over
People
15
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT07194044
Phase 1Taking people
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
Where
New Have, Santa Monica
Age
18 years and over
People
76 worldwide
Run by
Kivu Bioscience Inc.
See details and how to joinNCT07229313
Early phase 1Taking people
A Trial to Evaluate CSF ctDNA and Safety of Plixorafenib Alone or With Retifanlimab in Patients With BRAF-altered Glioma
Where
Baltimore, New York
Age
18 years and over
People
24
Run by
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
See details and how to joinNCT06610682
Phase 1Taking people
A Study of CRD3874-SI in People With Solid Tumors
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
81
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06021626
Phase 1/2Taking people
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
Where
Ann Arbor, Baton Rouge, Boston, Fairfax, Hackensack, Houston, Nashville, New York, Sarasota, Tampa
Age
18 years and over
People
265 worldwide
Run by
Blueprint Medicines Corporation
See details and how to joinNCT07629960
No phaseTaking people
DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins
Where
Houston
Age
1 year and over
People
60
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07298083
Phase 1Taking people
A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas
Where
Seattle
Age
18 years and over
People
18
Run by
University of Washington
See details and how to joinNCT06025747
Phase 1Not yet taking people in United States
EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT
Where
Cleveland
Age
2 years and over
People
24
Run by
Rabi Hanna
See details and how to joinNCT07695311
Phase 1/2Taking people
A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
54
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06843967