Sarcoma trials in United States

In United States 300 Also abroad 605

300 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Not yet taking people in United States
Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall
Where
Columbus
Age
18 years and over
People
228
Run by
Ohio State University Comprehensive Cancer Center
See details and how to joinNCT07823491
Phase 1Taking people
A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma
Where
Harrison, New York
Age
18 years and over
People
40
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05607095
Phase 2Taking people
Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities
Where
Houston
Age
18 years and over
People
227
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04751409
No phaseTaking people
Biomarkers of Resiliency In Childhood Cancer Surgery
Where
Rochester
Age
3 years to 25 years
People
40
Run by
Mayo Clinic
See details and how to joinNCT06674811
Phase 1/2Taking people
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Where
Aurora, Houston, Miami, New York
Age
18 years and over
People
270 worldwide
Run by
Adcendo ApS
See details and how to joinNCT06797999 · EU 2024-516900-41-00
No phaseTaking people
Financial Toxicity in Patients With Resected Soft Tissue and Bone Sarcomas
Where
Houston
People
100
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07215611
Phase 1/2Not yet taking people in United States
A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers
Where
Houston
Age
18 years and over
People
138
Run by
Advenchen Pharmaceuticals, LLC.
See details and how to joinNCT07811232
Phase 1/2Not yet taking people in United States
A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers
Where
Houston
Age
18 years and over
People
138
Run by
Advenchen Pharmaceuticals, LLC.
See details and how to joinNCT07811297
Phase 1Taking people
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Where
Fairfax, Houston, Los Angeles, Nashville, San Antonio, Sarasota, St Louis
Age
18 years and over
People
80
Run by
Angiex, Inc.
See details and how to joinNCT06440005
Phase 1Taking people
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
Where
Ann Arbor, Atlanta, Aurora, Beverly Hills, Charlottesville, Chicago, Cincinnati, Cleveland, Duarte, Fairfax, Grand Rapids, Houston, Los Angeles, Nashville, New York, Orange, Philadelphia, Portland, San Antonio, San Diego, San Francisco, Santa Monica, Scottsdale
Age
12 years to 85 years
People
411 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT03715933 · EU 2023-508139-29-00
Phase 1/2Taking people
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Where
New York
Age
18 years and over
People
98
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT04577014
Phase 1/2Taking people
Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors
Where
Boston, Chicago, Detroit, Fairfax, Grand Junction, Houston, Lake Mary, Miami, Nashville, New York, Palo Alto, Salt Lake City, Urbana, Zion
Age
18 years and over
People
225 worldwide
Run by
Tango Therapeutics, Inc.
See details and how to joinNCT05732831
Phase 1Taking people
First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors
Where
Boston, Nashville, New York
Age
18 years and over
People
150 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06644755
No phaseTaking people
Clinical Orthopaedic Data Bank (Acute and Chronic)
Where
Gainesville
People
10,000
Run by
University of Florida
See details and how to joinNCT00411060
No phaseTaking people
GRID Therapy for Extremity Soft Tissue Sarcoma
Where
Chapel Hill
Age
18 years and over
People
20
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT06073067
Phase 1Taking people
Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas
Where
Aurora, Philadelphia, San Francisco
Age
5 years to 40 years
People
30
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT06156410
Phase 1/2Taking people
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
Where
Birmingham, Dallas, Gainesville, Hackensack, Hartford, Hershey, Honolulu, Kansas City, Little Rock, Miami, Nashville, Orlando, St Louis, Tampa
Age
Up to 26 years
People
265
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT06465199
Phase 1/2Taking people
Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and Osteosarcoma
Where
Columbus, St Louis, Tampa, The Bronx
Age
12 years to 40 years
People
74
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT07725380
No phaseTaking people
Serial MRI Scans During Radiation Therapy
Where
Boston
Age
18 years and over
People
149
Run by
Dana-Farber Cancer Institute
See details and how to joinNCT04188535
Phase 1Taking people
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
Where
Brookline, Chapel Hill, Chicago, Dallas, Fairfax, Fort Worth, Grand Rapids, Houston, Jacksonville, Lone Tree, Milwaukee, Mineola, Nashville, New Brunswick, New York, Norton Shores, Orlando, Phoenix, Port Jefferson Station, Rochester, San Antonio, Seattle, Tyler
Age
18 years and over
People
336
Run by
Bristol-Myers Squibb
See details and how to joinNCT05245500
No phaseTaking people
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
26
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05837767
Phase 1/2Taking people
Lurbinectedin in FET-Fused Tumors
Where
Ann Arbor, Boston, Iowa City, Los Angeles, New York, Philadelphia
Age
10 years and over
People
63
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT05918640
Phase 2Taking people
KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)
Where
Clermont, Fargo, Sioux Falls
Age
18 years and over
People
140 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07252739 · EU 2025-521939-36-00
Phase 1Taking people
Losartan + Sunitinib in Treatment of Osteosarcoma
Where
Atlanta, Aurora, Los Angeles
Age
10 years and over
People
41
Run by
University of Colorado, Denver
See details and how to joinNCT03900793
Phase 2Taking people
Intratumoral Vusolimogene Oderparepvec (VO) in Combination With Pembrolizumab for Angiosarcoma
Where
San Francisco
Age
18 years and over
People
18
Run by
Varun Monga, MBBS
See details and how to joinNCT06898970