Systemic sclerosis (scleroderma) trials in United States

In United States 53 Also abroad 213

53 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
FT839 in Autoimmune Diseases
Where
Fullerton
Age
18 years to 70 years
People
446
Run by
Fate Therapeutics
See details and how to joinNCT07800871
Phase 2Taking people
Platform Clinical Study for Conquering Scleroderma
Where
Ann Arbor, Atlanta, Baltimore, Birmingham, Boston, Charleston, Chicago, Cleveland, Durham, Great Neck, Houston, Kansas City, Los Angeles, Milwaukee, Nashville, New Brunswick, New Haven, New York, Palo Alto, Philadelphia, Pittsburgh, Portland, Rochester, Salt Lake City, St Louis, Washington D.C.
Age
18 years and over
People
400 worldwide
Run by
Scleroderma Research Foundation, Inc.
See details and how to joinNCT06195072 · EU 2023-507129-40-00
Phase 2Taking people
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
Where
Pittsburgh
Age
8 years to 60 years
People
8
Run by
Paul Szabolcs
See details and how to joinNCT03630211
Phase 2Taking people
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Where
Arlington, Bellaire, Charleston, Charlotte, Chula Vista, Covina, Gainesville, Great Falls, Hixson, Iowa City, Irving, Jackson, Jupiter, Katy, Los Alamitos, Los Angeles, Mesquite, Miami, Norcross, Phoenix, Plantation, Red Oak, Roanoke, Santa Ana, Statesville, Tucson, Tuscaloosa, Tustin, Willowbrook, Woodland
Age
18 years and over
People
90 worldwide
Run by
Artiva Biotherapeutics, Inc.
See details and how to joinNCT06991114 · EU 2025-520461-41-00
Phase 1Not yet taking people in United States
BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Autoimmune Disease
Where
Boston
Age
16 years to 75 years
People
94
Run by
Luminary Therapeutics
See details and how to joinNCT07729995
No phaseTaking people
Diffuse Cutaneous Scleroderma (DSSc) SFDI Study
Where
Boston
Age
18 years and over
People
65
Run by
Boston University
See details and how to joinNCT07090226
Phase 1Taking people
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Where
Boston, Durham
Age
18 years and over
People
125 worldwide
Run by
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
See details and how to joinNCT07115745 · EU 2024-517681-41-00
Phase 2Taking people
A Study of Microbiome Transplantation for the Treatment of Constipation and/or Significant Bloating in Patients With Systemic Sclerosis
Where
Houston
Age
18 years and over
People
21
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT06827977
No phaseTaking people
Systemic Sclerosis DIet for GastrointESTinal Symptoms
Where
Ann Arbor
Age
18 years and over
People
60
Run by
University of Michigan
See details and how to joinNCT07402226
Phase 1Taking people
US Zamto-cel Autoimmune Diseases
Where
Milwaukee
Age
18 years and over
People
48
Run by
Miltenyi Biomedicine GmbH
See details and how to joinNCT06708845
Phase 1Taking people
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
Where
Beverly Hills, Cleveland, Durham, Fullerton, Gainesville, Irvine, Los Angeles, Louisville, Memphis, Miami, Minneapolis, New York, Oklahoma City, Omaha, Philadelphia, San Francisco
Age
12 years to 70 years
People
244 worldwide
Run by
Fate Therapeutics
See details and how to joinNCT06308978
No phaseTaking people
Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
Where
Dallas
Age
Up to 90 years
People
500
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT01808937
Phase 2Taking people
Intralesional Injection of STS in Treatment of Calcinosis
Where
Pittsburgh
Age
18 years and over
People
20
Run by
Robyn T. Domsic, MD, MPH
See details and how to joinNCT06672822
Phase 2Taking people
A Study of Nemolizumab for the Treatment of Adults With Systemic Sclerosis
Where
Ann Arbor, Arlington
Age
18 years and over
People
162 worldwide
Run by
Galderma R&D
See details and how to joinNCT07047690 · EU 2025-522294-11-00
Phase 4Taking people
Open Label Treprostinil Raynaud's Study
Where
Boston
Age
18 years and over
People
30
Run by
Brigham and Women's Hospital
See details and how to joinNCT07112183
Phase 1Enrolling by invitation
A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease
Where
Buffalo, Redwood City
Age
18 years to 80 years
People
180
Run by
Adicet Therapeutics
See details and how to joinNCT06375993
No phaseTaking people
EFESO: Study on Juvenile Onset Eosinophilic Fasciitis
Where
Birmingham, Syracuse
Age
Up to 18 years
People
20 worldwide
Run by
Meyer Children's Hospital IRCCS
See details and how to joinNCT07348263
No phaseTaking people
Rheumatology Patient Registry and Biorepository
Where
New Haven
Age
18 years to 99 years
People
5,000
Run by
Yale University
See details and how to joinNCT04402086
Phase 2/3Taking people
A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
Where
Denver
Age
18 years and over
People
70 worldwide
Run by
Kyverna Therapeutics
See details and how to joinNCT07403188 · EU 2024-511198-31-00
No phaseTaking people
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Where
Durham
People
1,000
Run by
Duke University
See details and how to joinNCT03276923
No phaseTaking people
The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life
Where
Ann Arbor, Nashville, New Orleans, Pittsburgh
Age
18 years and over
People
160
Run by
Robyn T. Domsic, MD, MPH
See details and how to joinNCT06675344
No phaseTaking people
Scleroderma Registry & Repository at the Hospital for Special Surgery
Where
New York
Age
18 years and over
People
300
Run by
Hospital for Special Surgery, New York
See details and how to joinNCT01656447
Phase 2Taking people
Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases
Where
Philadelphia
Age
8 years to 25 years
People
20
Run by
Stephan Grupp MD PhD
See details and how to joinNCT05029336
No phaseTaking people
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Where
Houston
Age
18 years and over
People
60
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT05989763
Phase 2Taking people
Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)
Where
Charleston, Chicago, Cleveland, Dallas, Houston, Los Angeles, Miami, New Orleans, New York, Oklahoma City, Richmond, Salt Lake City, San Diego
Age
18 years and over
People
25
Run by
aTyr Pharma, Inc.
See details and how to joinNCT05892614