Clinical trials

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164 trials

NCT06941389
Recruiting
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Not applicable · Canada, United States · 37 sites
Registry update: 4 Jun 2026
NCT06313398
Recruiting
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
Early phase 1 · United States · 1 site
Registry update: 28 Sept 2026
NCT06035939
Recruiting
SMYLS Multi-site Trial
Not applicable · United States · 1 site
Registry update: 8 Dec 2025
NCT06358638
Recruiting
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody
Phase 2 · United States · 1 site
Registry update: 26 Sept 2025
NCT07800247
Recruiting
Hemoglobin Disorders in Egypt: Sickle Cell Disease Ain Shams University Institutional Registry
Not applicable · Egypt · 2 sites
Registry update: 2 Sept 2026
NCT06529874
Recruiting
Pressure Pain Tolerance in Relation to Balance and Strength in Children
Not applicable · Egypt · 1 site
Registry update: 1 Apr 2025
NCT05285917
Recruiting
Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa
Phase 3 · Angola · 1 site
Registry update: 20 Aug 2026
NCT05583721
Recruiting
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Phase 2 · United States · 1 site
Registry update: 6 May 2026
NCT07116772
Recruiting
Serial Assessment of Fertility Experiences
Not applicable · Dominican Republic, Jamaica, Tanzania · 3 sites
Registry update: 4 Feb 2026
NCT05953584
Recruiting
A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke
Phase 2 · India, Nigeria, Oman · 9 sites
Registry update: 10 Sept 2026
NCT06385886
Recruiting
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
Not applicable · United States · 9 sites
Registry update: 22 Jun 2025
NCT05810181
Recruiting
Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)
Not applicable · United States · 1 site
Registry update: 10 Aug 2026
NCT05640271
Recruiting
Tocilizumab for Acute Chest Syndrome
Phase 2 · United States · 1 site
Registry update: 15 Sept 2026
NCT05392894
Recruiting
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease
Phase 3 · United Kingdom · 1 site
Registry update: 10 May 2023
NCT05736419
Recruiting
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
Phase 2 · United States · 6 sites
Registry update: 3 Jun 2026
NCT06198712
Recruiting
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
Phase 2 · Canada, France, United Kingdom, Kenya, Lebanon, Nigeria · 18 sites
Registry update: 18 Sept 2026
NCT05099874
Recruiting
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Not applicable · United States · 1 site
Registry update: 10 Jan 2025
NCT05799118
Recruiting
Study of the Role of Genetic Modifiers in Hemoglobinopathies
Not applicable · Angola, Argentina, Belgium, Brunei, Cyprus, Denmark, Spain, Greece, Israel, Italy, Malaysia, Nigeria, Pakistan, Portugal, United States · 26 sites
Registry update: 20 Mar 2024
NCT05431088
Recruiting
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Phase 2/3 · Belgium, Brazil, Germany, Spain, France, United Kingdom, Greece, India, Italy, Kenya, Nigeria, Saudi Arabia, United States · 96 sites
Registry update: 18 Aug 2026
NCT07083531
Recruiting
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
Not applicable · United States · 1 site
Registry update: 24 Jul 2025

Ordered by registry start date. Freshness and sponsorship never change the order.