Retinitis pigmentosa: trials for referral
77 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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77 trials shown
No phase1 site
RecruitingCanada
NCT07341763
Brain Stimulation Effects on Orientation and Mobility Skills in Adults With Vision Impairment
University of Waterloo
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 2/314 sites
RecruitingUnited States
NCT07901751
Study to Evaluate the Efficacy of a Single Intravitreal Injection of RTx-015 in Participants With Retinitis Pigmentosa (PERCEPT)
Ray Therapeutics, Inc.
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 12 sites
RecruitingGreece, United States
NCT05147701
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
The Foundation for Orthopaedics and Regenerative Medicine
Registry updated 16 Oct 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingChina
NCT05805007
Safety and Tolerability Study of Gene Editing Drug ZVS203e in Participants With Retinitis Pigmentosa
Peking University Third Hospital
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govPhase 1/25 sites
RecruitingUnited States
NCT06789445
A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO)
BlueRock Therapeutics
Registry updated 15 Oct 2026
Registry record: ClinicalTrials.govPhase 31 site
RecruitingUnited States
NCT07710196
A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome
Nacuity Pharmaceuticals, Inc.
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingJapan
NCT07774975
Safety Evaluation Study of Pitavastatin PLGA Nano-particle for Retinitis Pigmentosa
Kyushu University
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.govPhase 1/211 sites
RecruitingUnited States
NCT06467344
Study to Evaluate ACDN-01 in ABCA4-related Stargardt Retinopathy (STELLAR)
Ascidian Therapeutics, Inc
Registry updated 7 Oct 2026
Registry record: ClinicalTrials.govPhase 10 sites
Not yet recruiting
NCT07847723
Phase I/II Open-Label Trial of UGX202 for Advanced Retinitis Pigmentosa
Suzhou UgeneX Therapeutics Co., Ltd.
Registry updated 2 Oct 2026
Registry record: ClinicalTrials.govPhase 1/22 sites
RecruitingUnited States
NCT07408232
A Phase 1/2 Study in Healthy Volunteers and Participants With Autosomal Dominant Retinitis Pigmentosa (RHO-adRP)
Octant, Inc.
Registry updated 24 Sept 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingUnited States
NCT06319872
The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration
University of Rochester
Registry updated 16 Sept 2026
Registry record: ClinicalTrials.govPhase 1/23 sites
RecruitingBelgium, France, Ireland
NCT07807111
Open-Label Study to Evaluate the Safety, Tolerability, and Efficacy of Gene Therapy (SPVN20) in Subjects With Rod-Cone Dystrophy
SparingVision
Registry updated 8 Sept 2026
Registry record: ClinicalTrials.govPhase 20 sites
Not yet recruiting
NCT07796646
Study to Evaluate the Long-Term Safety of Ultevursen in Participants With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene
Laboratoires Thea
Registry updated 1 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingAustralia
NCT07266584
Restoration of Central Vision With PRIMA in Patients With Photoreceptor Degeneration
Science Corporation
Registry updated 17 Aug 2026
Registry record: ClinicalTrials.govPhase 30 sites
Not yet recruiting
NCT07290530
24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome
Nacuity Pharmaceuticals, Inc.
Registry updated 1 Jul 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingChina
NCT07656753
Safety and Efficacy Study of PUMCH-E111 Injection in Subjects With RLBP1 Related Inherited Retinal Dystrophy
Peking Union Medical College Hospital
Registry updated 18 Jun 2026
Registry record: ClinicalTrials.govPhase 25 sites
RecruitingAustralia
NCT06628947
A Phase II Study of Intravitreal KIO-301 in Patients With Late-stage Retinitis Pigmentosa
Kiora Pharmaceuticals, Inc.
Registry updated 18 Jun 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingChina
NCT06952842
Safety and Efficacy of ZVS203e in the Treatment of Retinitis Pigmentosa Caused by RHO Gene Mutation
Chigenovo Co., Ltd
Registry updated 17 Jun 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
By invitation onlyUnited States
NCT06565572
Antisense Oligonucleotide Treatment for PCARP Disease Due to Mutation in FLVCR1
University of Colorado, Denver
Registry updated 19 May 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingUnited States
NCT05626920
Disulfiram for Treatment of Retinal Degeneration
University of Washington
Registry updated 5 May 2026
Registry record: ClinicalTrials.govPhase 1/22 sites
RecruitingUnited States
NCT06891885
A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa
Sumitomo Pharma America, Inc.
Registry updated 17 Apr 2026
Registry record: ClinicalTrials.govPhase 1/20 sites
Not yet recruiting
NCT07282457
Prospective, Randomized, Sham-controlled, Dose-finding I/II Trial of Safety and Efficacy of Modified Optogenetic Gene Therapy (ZM-02 Injection)
Augelux Therapeutics
Registry updated 13 Apr 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingChina
NCT06292650
Safety and Efficacy Study of Novel Gene Therapy ZM-02 for Retinitis Pigmentosa Patients
Augelux Therapeutics
Registry updated 31 Mar 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
RecruitingChina
NCT07063030
A Study of LX107 Gene Therapy in AIPL1-IRD Patients
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Registry updated 10 Mar 2026
Registry record: ClinicalTrials.govPhase 2/31 site
Not yet recruitingIndonesia
NCT05909488
Role of UC-MSC and CM to Inhibit Vision Loss in Retinitis Pigmentosa Phase I/II
PT. Prodia Stem Cell Indonesia
Registry updated 25 Feb 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingUnited States
NCT04278131
BS01 in Patients With Retinitis Pigmentosa
Bionic Sight LLC
Registry updated 23 Jan 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
Not yet recruitingChina
NCT07311863
UGX202 Injection in Patients With Advanced Retinitis Pigmentosa
Suzhou UgeneX Therapeutics Co., Ltd.
Registry updated 31 Dec 2025
Registry record: ClinicalTrials.govNo phase1 site
RecruitingChina
NCT05853107
Pilot Study of AuTNA I
Eye & ENT Hospital of Fudan University
Registry updated 19 Sept 2025
Registry record: ClinicalTrials.govNo phase1 site
By invitation onlyPoland
NCT07088705
Subthreshold Micropulse Laser Therapy (SML) in Retinitis Pigmentosa
Marta P. Wiącek
Registry updated 31 Jul 2025
Registry record: ClinicalTrials.govPhase 31 site
Not yet recruitingChina
NCT07082855
A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa
Zhongshan Ophthalmic Center, Sun Yat-sen University
Registry updated 24 Jul 2025
Registry record: ClinicalTrials.gov
The same sites as a list
- United States28 open trials
- China11 open trials
- France8 open trials
- Germany6 open trials
- Australia5 open trials
- Italy5 open trials
- Israel5 open trials
- Belgium4 open trials
- Canada3 open trials
- Ireland2 open trials
- Indonesia2 open trials
- United Kingdom2 open trials
- Netherlands2 open trials
- Greece1 open trial
- Japan1 open trial
- Poland1 open trial
- Thailand1 open trial
- Switzerland1 open trial
- Mexico1 open trial
- Norway1 open trial
- Brazil1 open trial
- Finland1 open trial
- Spain1 open trial
- United Arab Emirates1 open trial
- Austria1 open trial
- Russia1 open trial
- Egypt1 open trial
- India1 open trial
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
Paris, France
9 trials · 9 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Closed for recruitment
NCT03326336 · Phase 1/2 · France, United Kingdom, United States
Source: ClinicalTrials.govOpened for recruitment
NCT03326336 · Phase 1/2 · France, United Kingdom, United States
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
Phase 3Ended 22 Jun 2026
Phase 1/2Ended 12 May 2026
Completed12 participants
NCT03374657
A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa
Phase 1/2Ended 22 Apr 2026
Completed49 participants
NCT04355689
Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome
Phase 1/2Ended 24 Mar 2026
Completed32 participants
NCT05282953
A Phase I/II Dose-escalating Study of the Safety, Tolerability and Efficacy of KIO-301 Administered Intravitreally to Patients With Retinitis Pigmentosa and Choroideremia (ABACUS)
- Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial. · Nature medicine, 2026
No phaseEnded 5 Feb 2026
Completed137 participants
NCT06177977
SS-HH-OCT as a Novel Diagnostic Modality for Early-Onset Retinal Dystrophies (EORDs)
Phase 1Ended 24 Sept 2025
Completed6 participants
NCT06455826
MAD of IVT VP-001 in PRPF31 Mutation-Associated Retinal Dystrophy Subjects (Wallaby)
No phaseEnded 17 Sept 2025
No phaseEnded Jul 2025
Withdrawn before start0 participants
NCT03629899
RETINA IMPLANT Alpha AMS in Blind Patients With Retinitis Pigmentosa
Reason given: unavailability of the investigational device
Phase 1/2Ended 30 Jun 2025
No phaseEnded 30 Jun 2025
Completed87 participants
NCT03597399
A Patient Registry Study for Patients Treated With Voretigene Neparvovec in US
No phaseEnded May 2025
Completed50 participants
NCT02759952
Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial
No phaseEnded Mar 2025
Withdrawn before start0 participants
NCT05841862
Intravitreal Quantum Dots (QD) for Advanced Retinitis Pigmentosa (RP) (QUANTUM)
Reason given: Lack of funding.
No phaseEnded 20 Dec 2024
Stopped early32 participants
NCT04558983
A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa
Reason given: The study stopped because patients dropped out of the study to participate in the interventional trials. With interventional trials present there is very little interest in participating in a Natural Histoy study.
No phaseEnded 7 Nov 2024
No phaseEnded 2 Nov 2024
Completed120 participants
NCT05793515
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models
Phase 1/2Ended 21 Oct 2024
Completed14 participants
NCT02556736
AGN-151597 (Formerly RST-001) Phase I/II Trial for Advanced Retinitis Pigmentosa
Phase 3Ended 30 Sept 2024
Completed105 participants
NCT04671433
Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
No phaseEnded 30 Sept 2024
Completed26 participants
NCT04359108
Environmental Localization Mapping and Guidance for Visual Prosthesis Users
Phase 1/2Ended 5 Aug 2024
Stopped early8 participants
NCT04120883
Oral Hydroxychloroquine (HCQ) for Retinitis Pigmentosa Caused by P23H- Rhodopsin (RHO)
Reason given: Unable to recruit additional participants after multiple extensions to planned enrollment period.
Phase 1/2Ended 24 Apr 2024
Stopped early14 participants
NCT05392751
Dose Escalation Study to Evaluate the Safety/Tolerability and Efficacy of EA-2353 in Subjects With Retinitis Pigmentosa
Reason given: Study terminated by the Sponsor. All study participants completed at least 12 months of safety follow-up instead of 24 mo. The reason for earlier termination was due to a corporate decision; not any safety concerns of EA-2353.
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No phaseEnded 23 Apr 2024
Completed15 participants
NCT04868916
An Observational Study of Japanese Participants With X-linked Retinitis Pigmentosa
No phaseEnded 19 Apr 2024
Completed140 participants
NCT03349242
Natural History Study of Patients With X-linked Retinal Dystrophy Associated With Mutations in Retinitis Pigmentosa GTPase Regulator (RPGR)
No phaseEnded 31 Mar 2024
Completed39 participants
NCT06377150
ABCA4-associated Disease in Childhood and Adolescence - a Phenotype Study
Phase 2Ended 18 Jan 2024
Completed27 participants
NCT04945772
Efficacy and Safety of MCO-010 Optogenetic Therapy in Adults With Retinitis Pigmentosa [RESTORE]
No phaseEnded 21 Dec 2023
Phase 2Ended 1 Dec 2023
Not medical advice. fetched 10 Nov 2026