ALS (motor neurone disease): open trials in United States

89 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT04097158
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
Research · Loma Linda University
Loma Linda University, Loma Linda
Registry updated 2026-06-05
NCT05724173
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
Trial Treatment · Leigh R. Hochberg, MD, PhD.
Massachusetts General Hospital, Boston · Stanford University School of Medicine, Stanford
Registry updated 2026-06-02
NCT00912041
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Trial Treatment · Leigh R. Hochberg, MD, PhD.
Emory University School of Medicine, Atlanta · Massachusetts General Hospital, Boston · Baylor College of Medicine, Houston · Providence VA Medical Center, Providence · University of California - Davis, Sacramento · Stanford University School of Medicine, Stanford
Registry updated 2026-06-01
NCT07187388
Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
Trial Treatment · Nova Southeastern University
Nova Southeastern University, David and Cathy Husman Neuroscience Institute, Davie
Registry updated 2026-05-27
NCT05966038
ALS/MND Natural History Study Data Repository
Research · Massachusetts General Hospital
Lahey Clinic, Burlington · Northwestern University, Chicago · Henry Ford Health System, Detroit · University of Florida, Gainesville · Trinity Health Michigan, Grand Rapids · Loma Linda University Health, Loma Linda · Kaiser Permanente, Los Angeles · University of Minnesota, Minneapolis · Temple University Lewis Katz School of Medicine, Philadelphia · Thomas Jefferson University, Philadelphia · University of Pittsburgh, Pittsburgh · Providence ALS Clinic, Portland · Virginia Commonwealth University, Richmond · Saint Louis University, St Louis
Registry updated 2026-05-20
NCT01772602
The National Amyotrophic Lateral Sclerosis Registry
Research · Centers for Disease Control and Prevention
CDC, Atlanta
Registry updated 2026-04-29
NCT06491732
EIM Via the Myolex mScan as an ALS Biomarker
Research · Beth Israel Deaconess Medical Center
University of Michigan, Ann Arbor · Beth Israel Deaconess Medical Center, Boston · Massachusetts General Hospital, Boston · Dartmouth Hitchcock Medical Center, Lebanon · Barrow Neurological Institute, Phoenix · Atrium Health Wake Forest Baptist Medical Center, Winston-Salem
Registry updated 2026-04-22
NCT06665165
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Trial Treatment · Phase 1 · Amylyx Pharmaceuticals Inc.
Massachusetts General Hospital, Healey & AMG Center for ALS, Boston · University of Florida, Gainesville · Houston Methodist Neurological Institute, Houston · Mayo Clinic in Florida, Jacksonville · Alliance for Multispecialty Research, LLC, Knoxville · University of California San Diego, La Jolla · Orlando Regional Medical Center, Orlando Health Neuroscience Institute, Orlando · Temple University Of the Commonwealth System of Higher Education, Philadelphia · Mayo Clinic in Rochester, Rochester · Georgetown University Hospital Pasquerilla Healthcare Center, Washington D.C.
Registry updated 2026-04-14
NCT07357428
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
Trial Treatment · Paradromics
University of Michigan, Ann Arbor · Massachusetts General Hospital, Boston · University of California - Davis, Sacramento
Registry updated 2026-04-14
NCT07259980
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
Research · Biogen
Mass General Hospital -MGH, Boston
Registry updated 2026-04-09
NCT06819124
Examining Interactions Between PALS and Caregivers
Trial Treatment · Penn State University
Speech Core, Pennsylvania State University, University Park
Registry updated 2026-04-06
NCT07491484
Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
Research · TidalHealth, Inc.
TidalHealth Peninsula Regional, Inc., Salisbury
Registry updated 2026-03-24
NCT00136500
Clinical Research in ALS Study
Research · University of Miami
University of Miami, Miami
Registry updated 2026-03-20
NCT00317616
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Research · University of Miami
University of Miami, Miami
Registry updated 2026-03-20
NCT06172621
Spinal Cord Associative Plasticity for ALS
Trial Treatment · VA Office of Research and Development
James J. Peters VA Medical Center, Bronx, NY, The Bronx
Registry updated 2026-03-20
NCT07221240
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
Trial Treatment · Phase 1 · PRG Science & Technology Co., Ltd.
Pharmaron, Inc., Baltimore
Registry updated 2026-03-05
NCT07298486
Impact of Robotic Glove Use on Quality of Life, Grip Strength and Fine Motor Control in ALS
Trial Treatment · Nova Southeastern University
Nova Southeastern University, David and Cathy Husman Neuroscience Institute, Davie
Registry updated 2026-02-25
NCT07423494
Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576)
Trial Treatment · Phase 1/2 · n-Lorem Foundation
Mayo Clinic, Rochester
Registry updated 2026-02-20
NCT06828523
Assessing Perceptual Effects of Interactive Tasks
Trial Treatment · Penn State University
Speech Core, Pennsylvania State University, University Park
Registry updated 2026-02-12
NCT05104710
Intermuscular Coherence as a Biomarker for ALS
Research · University of Chicago
Massachusetts General Hospital, Boston · University of California Center for Clinical Research, Irvine · University of Miami Miller School of Medicine, Miami · Washington University Medical Center, St Louis
Registry updated 2026-02-09
NCT03233646
Retinal Imaging in Neurodegenerative Disease
Research · Duke University
Duke University Medical Center, Durham
Registry updated 2026-02-04
NCT04715399
UPenn Observational Research Repository on Neurodegenerative Disease
Research · University of Pennsylvania
University of Pennsylvania, Philadelphia
Registry updated 2026-01-22
NCT06429735
Precise Robotically IMplanted Brain-Computer InterfacE
Trial Treatment · Neuralink Corp
University of Miami, Miami · Barrow Neurological Institute, Phoenix
Registry updated 2026-01-09
NCT03865420
Amyotrophic Lateral Sclerosis (ALS) Families Project
Research · Columbia University
Columbia University, New York
Registry updated 2026-01-07
NCT05116943
Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders
Research · Mayo Clinic
Mayo Clinic in Florida, Jacksonville
Registry updated 2025-12-16

All ALS (motor neurone disease) trials and the map

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