Colorectal cancer trials in Belgium

In Belgium 77 Also abroad 1929

77 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
Where
Ghent
Age
18 years and over
People
130 worldwide
Run by
Bayer
See details and how to joinNCT07535112 · EU 2025-523648-11-00
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Kortrijk
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 2Not yet taking people in Belgium
A phase 2, single arm, open label, study on the safety and feasibility of Liver Isolated Oxaliplatin (LIOX) delivered via arterial access device for treatment of liver metastasis in colorectal cancer patients
Where
Leuven
Age
18 years and over
People
13
Run by
UZ Leuven
See details and how to join2025-523261-25-00 · EU 2025-523261-25-00
Phase 1Taking people
A Phase 1 Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Denikitug (GS-1811), an Afucosylated Anti-CCR8 Monoclonal Antibody, as Monotherapy and in Combination With an Anti–PD-1 Monoclonal Antibody in Adults With Advanced Solid Tumors
Where
Edegem, Hasselt, Leuven
Age
18 years and over
People
93 worldwide
Run by
Gilead Sciences Inc.
See details and how to joinNCT05007782 · EU 2022-501684-40-00
Phase 1/2Taking people
A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer
Where
Anderlecht
Age
18 years and over
People
100 worldwide
Run by
SOTIO Biotech a.s.
See details and how to joinNCT07693751 · EU 2026-526235-19-00
No phaseTaking people
A Novel Clinical Decision Support Tool to Predict Submucosal Invasive Cancer Within Large Non-Pedunculated Colorectal Polyps
Where
Ghent
Age
18 years and over
People
886
Run by
University Hospital, Ghent
See details and how to joinNCT07705880
Phase 1/2Taking people
BreAK CRC (001) trial
Where
Anderlecht
Age
18 years and over
People
79 worldwide
Run by
Brenus Pharma
See details and how to join2024-512011-45-00 · EU 2024-512011-45-00
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Brussels, Charleroi, Ghent, Leuven, Mechelen, Roeselare, Sint-Niklaas
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
No phaseTaking people
PrOspEctive Metastases Imaging (POEM)
Where
Wilrijk
Age
18 years and over
People
50
Run by
Cancer Research Antwerp
See details and how to joinNCT07781306
Phase 1/2Taking people
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors
Where
Anderlecht, Leuven
Age
18 years and over
People
270 worldwide
Run by
Lumara Bio Oncologics GmbH
See details and how to joinNCT05706129 · EU 2023-504254-35-00
Phase 1Taking people
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
Where
Leuven
Age
18 years and over
People
307 worldwide
Run by
Xencor, Inc.
See details and how to joinNCT05433142 · EU 2024-513619-28-00
No phaseTaking people
Efficacy and Safety of Conventional Neoadjuvant Therapy Versus Total Neoadjuvant Therapy in Older Patients With Locally Advanced Rectal Cancer
Where
Anderlecht, Antwerp, Auderghem, Brussels, Charleroi, Edegem, Ghent, Godinne, Haine-Saint-Paul, Hornu, Libramont, Liège, Mons, Namur, Sint-Niklaas, Turnhout
Age
70 years and over
People
230
Run by
Jules Bordet Institute
See details and how to joinNCT06052332
Phase 3Taking people
Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
Where
Anderlecht, Charleroi, Gent, Leuven, Mechelen, Roeselare, Sint-Lambrechts-Woluwe, Sint-Niklaas
Age
18 years to 64 years
People
241 worldwide
Run by
Amgen Inc.
See details and how to join2022-502352-31-00 · EU 2022-502352-31-00
Phase 1Taking people
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
Where
Edegem, Ghent
Age
18 years and over
People
434 worldwide
Run by
Amgen
See details and how to joinNCT07094113
Phase 1Taking people
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Where
Brussels
Age
18 years to 100 years
People
162 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06562192
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Anderlecht, Edegem, La Louvière, Leuven, Liège, Sint-Lambrechts-Woluwe, Turnhout
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
Phase 1Taking people
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Where
Brussels, Edegem, Leuven
Age
18 years and over
People
710 worldwide
Run by
Incyte Corporation
See details and how to joinNCT06179160 · EU 2023-507091-47-00
Phase 1/2Taking people
A phase 1/2a, first-in-human, open-label, dose-escalating study with a safety expansion cohort to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary anti-tumour activity of TAX2 in patients with relapsed/refractory advanced/metastatic solid tumours
Where
Anderlecht, Gent
Age
18 years and over
People
48 worldwide
Run by
Apmonia Therapeutics
See details and how to join2025-521164-36-00 · EU 2025-521164-36-00
Phase 1/2Taking people
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
Where
Leuven
Age
12 years and over
People
500 worldwide
Run by
Turning Point Therapeutics, Inc.
See details and how to joinNCT03093116 · EU 2024-512606-25-00
Phase 1/2Taking people
Beamion BCGC-1: A study to find a suitable dose of zongertinib used alone and in combination with other treatments to test whether it helps people with different types of HER2+ cancer that has spread
Where
Edegem, Leuven, Libramont-Chevigny, Namur, Sint-Lambrechts-Woluwe
Age
18 years and over
People
181 worldwide
Run by
Boehringer Ingelheim International GmbH
See details and how to join2023-509566-38-00 · EU 2023-509566-38-00
Phase 2Taking people
A Study of Neoadjuvant Dostarlimab Plus Capecitabine Plus Oxaliplatin (CAPEOX) Vs CAPEOX With Previously Untreated T4N0 or Stage III Mismatch Repair Proficient (MMRp)/Microsatellite Stable (MSS) Colon Cancer
Where
Aalst, Bonheiden, Brussels, Ghent, Leuven, Liège, Ostend, Roeselare, Turnhout
Age
18 years and over
People
120 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06567782
No phaseNot yet taking people in Belgium
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Where
Ghent
Age
18 years and over
People
764
Run by
University Hospital, Ghent
See details and how to joinNCT07584486
Phase 1Taking people
Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-NNS309 in patients with pancreatic, lung, breast and colorectal cancers.
Where
Anderlecht
Age
18 years and over
People
76 worldwide
Run by
Novartis Pharma AG
See details and how to join2023-510356-23-00 · EU 2023-510356-23-00
Phase 3Taking people
FOLICOLOR TRIAL: Following Therapy Response Through Liquid Biopsy in Metatstatic Colorectal Cancer Patients
Where
Brasschaat, Bruges, Charleroi, Edegem, Ghent, Kortrijk, Mechelen, Sint-Niklaas, Wilrijk
Age
18 years and over
People
150
Run by
University Hospital, Antwerp
See details and how to joinNCT07558083
No phaseEnrolling by invitation
SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study
Where
Edegem, Leuven
Age
22 years and over
People
108 worldwide
Run by
SafeHeal Inc
See details and how to joinNCT07116668