Depression trials in Canada

In Canada 75 Also abroad 664

75 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial
Where
Toronto
Age
13 years to 18 years
People
300
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT05142683
No phaseTaking people
Integrated Suicide & Trauma Therapy for Suicide Risk
Where
Toronto
Age
18 years and over
People
20
Run by
Unity Health Toronto
See details and how to joinNCT05613972
No phaseTaking people
RCT of At-Home tDCS for Depression in Pregnancy
Where
Toronto
Age
18 years and over
People
156
Run by
Women's College Hospital
See details and how to joinNCT05097586
Phase 3Taking people
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Toronto, Verdun
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06963021 · EU 2024-519421-37-00
No phaseEnrolling by invitation
Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant Depression
Where
Toronto
Age
18 years and over
People
65
Run by
Joshua Rosenblat
See details and how to joinNCT07737990
Phase 2Taking people
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)
Where
Toronto
Age
18 years to 70 years
People
120
Run by
Joshua Rosenblat
See details and how to joinNCT07569198
No phaseTaking people
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Where
Hamilton
Age
18 years to 65 years
People
50
Run by
St. Joseph's Healthcare Hamilton
See details and how to joinNCT07250893
No phaseTaking people
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Where
Calgary, Halifax, Hamilton, Kingston, Ottawa, Toronto, Vancouver, Whitby
Age
18 years to 70 years
People
252
Run by
Abraham Nunes
See details and how to joinNCT06746155
Phase 4Taking people
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
Where
Calgary, Halifax, Hamilton, Kingston, Ottawa, Saskatoon, Toronto, Vancouver, Whitby
Age
18 years to 65 years
People
400
Run by
Nova Scotia Health Authority
See details and how to joinNCT05017311
No phaseNot yet taking people in Canada
Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging
Where
Ottawa
Age
18 years to 55 years
People
20
Run by
The Royal Ottawa Mental Health Centre
See details and how to joinNCT07620288
No phaseTaking people
Pharmacogenetics of Antidepressant-Induced Disinhibition
Where
Calgary
Age
6 years to 17 years
People
120
Run by
University of Calgary
See details and how to joinNCT03953014
No phaseTaking people
Home-Based tDCS for Depression in BPD
Where
Montreal
Age
18 years to 65 years
People
60
Run by
Ciusss de L'Est de l'Île de Montréal
See details and how to joinNCT06972368
Phase 1Not yet taking people in Canada
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
Where
Calgary
Age
18 years to 65 years
People
20
Run by
University of Calgary
See details and how to joinNCT07562074
Phase 2Not yet taking people in Canada
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
Where
Montreal
Age
21 years and over
People
16
Run by
Kyle Greenway
See details and how to joinNCT07373535
Phase 2Taking people
Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder
Where
Toronto
Age
18 years to 65 years
People
30
Run by
Roger McIntyre
See details and how to joinNCT07523048
Phase 2Taking people
A Randomized Neuroimaging Trial of Psilocybin in Depression
Where
Toronto
Age
18 years to 64 years
People
50
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT06072898
No phaseTaking people
Brain Imaging of Cognition Inn Schizophrenia and Depression
Where
Ottawa
Age
18 years to 60 years
People
90
Run by
The Royal Ottawa Mental Health Centre
See details and how to joinNCT04159662
No phaseTaking people
rTMS for Depression in Young Adults With Autism
Where
Toronto
Age
16 years to 35 years
People
80
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT04972136
No phaseTaking people
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
Where
Toronto
Age
60 years and over
People
150
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT06780917
No phaseTaking people
ACT_for Alcohol Use Disorder and Depression
Where
Montreal
Age
18 years to 70 years
People
30
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06620276
No phaseTaking people
A Novel Blood Test as a Biomarker in Mental Health
Where
New Westminster
Age
19 years and over
People
500
Run by
Fraser Health
See details and how to joinNCT06856161
No phaseNot yet taking people in Canada
Neuroimaging Markers of Midlife Depression and Cognitive Behavioural Therapy (CBT)
Where
Toronto
Age
40 years to 60 years
People
30
Run by
Baycrest
See details and how to joinNCT07091643
No phaseTaking people
Presynaptic Imaging in Major Depressive Episodes After COVID-19
Where
Toronto
Age
18 years to 75 years
People
90
Run by
Centre for Addiction and Mental Health
See details and how to joinNCT06086366
Phase 3Not yet taking people in Canada
Sustained Mood Improvement With Laughing Gas Exposure
Where
Toronto
Age
18 years to 65 years
People
120
Run by
Women's College Hospital
See details and how to joinNCT07262008
No phaseTaking people
Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression
Where
Toronto
Age
60 years to 85 years
People
24
Run by
Rotman Research Institute at Baycrest
See details and how to joinNCT07212465