Down syndrome trials in United States

In United States 48 Also abroad 94

13 of 48 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy
Where
Bethesda
Age
1 year to 120 years
People
700
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT07416201
No phaseTaking people
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment
Where
Atlanta, Baton Rouge, Houston, New York, Phoenix, Riverside, Sarasota, West Covina
People
1,000
Run by
BillionToOne Inc.
See details and how to joinNCT07643896
No phaseTaking people
Vascular Function in Adults With Down Syndrome
Where
Las Vegas
Age
18 years to 35 years
People
46
Run by
University of Nevada, Las Vegas
See details and how to joinNCT07630207
No phaseTaking people
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
Where
Birmingham, Camden, Charleston, Chicago, Detroit, Grand Rapids, Iowa City, Los Angeles, San Diego
Age
18 years and over
People
2,000 worldwide
Run by
Sequenom, Inc.
See details and how to joinNCT01429389
No phaseTaking people
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
Where
Akron, Albany, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Buffalo, Chapel Hill, Chicago, Cleveland, Columbia, Columbus, Dallas, Dayton, Detroit, Fargo, Fort Myers, Fort Worth, Grand Rapids, Greenville, Hackensack, Hollywood, Honolulu, Houston, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Madera, Madison, Marshfield, Memphis, Milwaukee, Minneapolis, Nashville, New Haven, Oakland, Oklahoma City, Omaha, Orlando, Pensacola, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Sacramento, San Antonio, San Diego, San Francisco, Seattle, Sioux Falls, Spokane, St Louis, Tampa, The Bronx, Wilmington, Winston-Salem
Age
6 years to 39 years
People
330 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT05702645
No phaseTaking people
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Where
Albuquerque, Aurora, Austin, Baltimore, Boston, Chapel Hill, Charleston, Chicago, Cincinnati, Columbia, Dallas, Durham, Hershey, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kansas City, Lebanon, Lexington, Little Rock, Los Angeles, Louisville, Madison, Milwaukee, Minneapolis, Morgantown, Nashville, New Orleans, Oklahoma City, Omaha, Palo Alto, Phoenix, Portland, Providence, Salt Lake City, Seattle, Sioux Falls, Wilmington
Age
0 years to 20 years
People
5,000 worldwide
Run by
Duke University
See details and how to joinNCT04278404
No phaseTaking people
Collaboration for Down Syndrome Progress (CDP)
Where
Aurora, Baltimore, Chapel Hill, Houston, Kansas City, Madison, Memphis, Miami, Minneapolis, Orange, Philadelphia, Pittsburgh, San Antonio, Seattle, St Louis
People
1,400
Run by
RTI International
See details and how to joinNCT07625579
No phaseTaking people
Trial-Ready Cohort-Down Syndrome (TRC-DS)
Where
Aurora, Beachwood, Boston, Cincinnati, Indianapolis, Kansas City, Las Vegas, Lexington, Madison, Nashville, Orange, Park Ridge, Phoenix, Pittsburgh, Portland, San Antonio, Staten Island, St Louis
Age
25 years to 55 years
People
550 worldwide
Run by
University of Southern California
See details and how to joinNCT04165109
No phaseTaking people
Patterns of Neurodevelopmental Disorders
Where
Phoenix
People
1,000
Run by
Richard Frye
See details and how to joinNCT06213090
No phaseTaking people
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
Where
The Woodlands
Age
4 years to 12 years
People
100
Run by
Healing Hope International
See details and how to joinNCT07493096
No phaseTaking people
Retinal Imaging in Neurodegenerative Disease
Where
Durham
Age
18 years and over
People
2,000
Run by
Duke University
See details and how to joinNCT03233646
No phaseTaking people
The Human Trisome Project
Where
Denver
Age
6 months to 89 years
People
2,500
Run by
University of Colorado, Denver
See details and how to joinNCT02864108
No phaseTaking people
DS-Connect®: The Down Syndrome Registry
Where
Aurora
People
100,000
Run by
University of Colorado, Denver
See details and how to joinNCT01950624