Down syndrome trials in United States

In United States 48 Also abroad 94

48 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Where
Akron, Albany, Albuquerque, Allentown, Anaheim, Anchorage, Ann Arbor, Arroyo Grande, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Battle Creek, Bellevue, Bellflower, Bethesda, Birmingham, Boise, Boston, Bridgeport, Brooklyn, Burlington, Carson City, Chapel Hill, Charleston, Charlotte, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Dearborn, Denver, Des Moines, Detroit, Downey, Duarte, Durham, East Lansing, El Paso, Falls Church, Fargo, Fontana, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Green Bay, Greenville, Hackensack, Hartford, Henderson, Hershey, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Kingman, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Lubbock, Madera, Madison, Martinsburg, Maywood, Mesa, Milwaukee, Mineola, Minneapolis, Mobile, Morgantown, Morristown, Muskegon, Nashville, Newark, New Brunswick, New Hyde Park, New Orleans, New York, Niles, Norfolk, Norton Shores, Oakland, Oklahoma City, Omaha, Orange, Orlando, Pahrump, Palo Alto, Parkersburg, Paterson, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reed City, Reno, Renton, Richmond, Rochester, Royal Oak, Sacramento, Saint Joseph, Salt Lake City, San Antonio, San Diego, San Francisco, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, St Louis, Stony Brook, St. Petersburg, Sylvania, Syracuse, Tacoma, Tampa, The Bronx, Toledo, Torrance, Traverse City, Troy, Tucson, Tulsa, Washington D.C., West Palm Beach, Wilmington, Winston-Salem, Wyoming, Yakima
Age
1 year to 30 years
People
461 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04546399
No phaseTaking people
Harness-based Mobility Intervention for Infants With Down Syndrome
Where
Boston
Age
Up to 2 years
People
6
Run by
Boston University Charles River Campus
See details and how to joinNCT06219863
No phaseNot yet taking people in United States
Executive Function Play Opportunities for Children With Down Syndrome
Where
Fort Collins
Age
36 months to 72 months
People
150 worldwide
Run by
Colorado State University
See details and how to joinNCT07792382
No phaseTaking people
Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy
Where
Bethesda
Age
1 year to 120 years
People
700
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT07416201
No phaseNot yet taking people in United States
Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance
Where
Boston
Age
18 years and over
People
50
Run by
Boston University Charles River Campus
See details and how to joinNCT07898592
Phase 2Taking people
Treatment of Atopic Dermatitis and Alopecia Areata With Abrocitinib in Individuals With Down Syndrome
Where
New York
Age
12 years and over
People
56
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07242638
No phaseTaking people
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment
Where
Atlanta, Baton Rouge, Houston, New York, Phoenix, Riverside, Sarasota, West Covina
People
1,000
Run by
BillionToOne Inc.
See details and how to joinNCT07643896
Phase 3Taking people
Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome
Where
Aurora
Age
18 years to 50 years
People
200
Run by
University of Colorado, Denver
See details and how to joinNCT07238465
Phase 2Taking people
A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
Where
Indianapolis, Maitland, Naples, St Louis
Age
40 years to 55 years
People
58 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT07636811 · EU 2025-523390-42-00
Phase 1Not yet taking people in United States
Escalating Doses of Memantine in Down Syndrome (MEDS-123)
Where
Cleveland
Age
18 years to 32 years
People
25
Run by
University Hospitals Cleveland Medical Center
See details and how to joinNCT07531940
No phaseTaking people
Vascular Function in Adults With Down Syndrome
Where
Las Vegas
Age
18 years to 35 years
People
46
Run by
University of Nevada, Las Vegas
See details and how to joinNCT07630207
Phase 2Taking people
Down Syndrome Obstructive Sleep Apnea
Where
Ann Arbor, Cincinnati, Cleveland, Los Angeles, Norfolk, Philadelphia, Seattle
Age
5 years to 18 years
People
230
Run by
Brigham and Women's Hospital
See details and how to joinNCT06043440
Phase 2Not yet taking people in United States
An Open-Label Phase II Feasibility Study for the Use of Ublituximab in Adults With Down Syndrome Regression Disorder
Where
Los Angeles
Age
18 years to 40 years
People
20
Run by
Jonathan Santoro
See details and how to joinNCT07812181
No phaseNot yet taking people in United States
Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome
Where
Chicago
Age
18 years and over
People
72
Run by
Northwestern University
See details and how to joinNCT07469176
No phaseTaking people
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
Where
Ann Arbor, Aurora, Cincinnati, Dallas, Houston, Norfolk, Portland
Age
2 years to 17 years
People
304
Run by
Oregon Health and Science University
See details and how to joinNCT05508971
No phaseTaking people
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
Where
Birmingham, Camden, Charleston, Chicago, Detroit, Grand Rapids, Iowa City, Los Angeles, San Diego
Age
18 years and over
People
2,000 worldwide
Run by
Sequenom, Inc.
See details and how to joinNCT01429389
Phase 4Taking people
Endotype DIrected Treatment for OSA in Down Syndrome
Where
Miami, Park Ridge, Philadelphia, San Diego, Tucson
Age
6 years and over
People
200
Run by
University of Arizona
See details and how to joinNCT07280468
Phase 2Taking people
Modulation of the Immune System in Down Syndrome for Improved Outcomes and Neurodevelopment - 1
Where
Aurora
Age
6 years to 22 years
People
92
Run by
University of Colorado, Denver
See details and how to joinNCT07598643
Phase 1/2Taking people
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
Where
Akron, Albany, Albuquerque, Allentown, Anchorage, Ann Arbor, Asheville, Atlanta, Aurora, Austin, Baltimore, Bangor, Bethesda, Birmingham, Boise, Boston, Brooklyn, Chapel Hill, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Corpus Christi, Dallas, Danville, Dayton, Denver, Des Moines, Detroit, Downey, Durham, East Lansing, El Paso, Falls Church, Fargo, Fort Lauderdale, Fort Myers, Fort Worth, Gainesville, Grand Rapids, Greenville, Hackensack, Hartford, Hershey, Hollywood, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Lebanon, Lexington, Little Rock, Loma Linda, Long Beach, Los Angeles, Louisville, Lubbock, Madera, Madison, Marshfield, Maywood, Memphis, Mesa, Miami, Mineola, Minneapolis, Mobile, Morgantown, Morristown, Nashville, Neptune City, New Brunswick, New Haven, New Hyde Park, New Orleans, New York, Norfolk, Oakland, Oak Lawn, Oklahoma City, Omaha, Orange, Orlando, Palo Alto, Park Ridge, Paterson, Pensacola, Peoria, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Richmond, Roanoke, Rochester, Royal Oak, Salt Lake City, San Antonio, San Diego, San Francisco, Savannah, Scarborough, Seattle, Sioux Falls, Spokane, Springfield, St Louis, Stony Brook, St. Petersburg, Syracuse, Tacoma, Tampa, The Bronx, Toledo, Tucson, Valhalla, Washington D.C., West Palm Beach, Wilmington, Winfield, Winston-Salem
Age
Up to 22 years
People
960 worldwide
Run by
PedAL BCU, LLC
See details and how to joinNCT04726241
No phaseTaking people
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
Where
Akron, Albany, Ann Arbor, Atlanta, Augusta, Austin, Baltimore, Birmingham, Buffalo, Chapel Hill, Chicago, Cleveland, Columbia, Columbus, Dallas, Dayton, Detroit, Fargo, Fort Myers, Fort Worth, Grand Rapids, Greenville, Hackensack, Hollywood, Honolulu, Houston, Jackson, Jacksonville, Kalamazoo, Kansas City, Knoxville, Las Vegas, Madera, Madison, Marshfield, Memphis, Milwaukee, Minneapolis, Nashville, New Haven, Oakland, Oklahoma City, Omaha, Orlando, Pensacola, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Reno, Sacramento, San Antonio, San Diego, San Francisco, Seattle, Sioux Falls, Spokane, St Louis, Tampa, The Bronx, Wilmington, Winston-Salem
Age
6 years to 39 years
People
330 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT05702645
No phaseTaking people
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Where
Albuquerque, Aurora, Austin, Baltimore, Boston, Chapel Hill, Charleston, Chicago, Cincinnati, Columbia, Dallas, Durham, Hershey, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kansas City, Lebanon, Lexington, Little Rock, Los Angeles, Louisville, Madison, Milwaukee, Minneapolis, Morgantown, Nashville, New Orleans, Oklahoma City, Omaha, Palo Alto, Phoenix, Portland, Providence, Salt Lake City, Seattle, Sioux Falls, Wilmington
Age
0 years to 20 years
People
5,000 worldwide
Run by
Duke University
See details and how to joinNCT04278404
No phaseTaking people
Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia
Where
Ann Arbor
Age
3 years to 21 years
People
40
Run by
University of Michigan
See details and how to joinNCT05527652
Phase 1Not yet taking people in United States
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
Where
Boston
Age
18 years and over
People
24
Run by
Brigham and Women's Hospital
See details and how to joinNCT07278492
No phaseTaking people
Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual Disabilities
Where
Kansas City
Age
18 years to 35 years
People
114
Run by
University of Kansas Medical Center
See details and how to joinNCT06961591
Phase 2Taking people
Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome
Where
Columbus
Age
5 years to 12 years
People
24
Run by
Ohio State University
See details and how to joinNCT07490444