Down syndrome trials in United States

In United States 48 Also abroad 94

48 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome
Where
Chestnut Hill
Age
15 years to 35 years
People
40
Run by
Boston College
See details and how to joinNCT07008989
No phaseEnrolling by invitation
Parent and Infant Inter(X)Action Intervention (PIXI)
Where
Research Triangle Park
Age
Up to 99 years
People
120
Run by
RTI International
See details and how to joinNCT03836300
Phase 1/2Taking people
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Where
Boston, Cordova, Fairway, Indianapolis, Lady Lake, Matthews, Nashville, Orlando, Phoenix, San Antonio, St Louis, The Villages
Age
35 years to 85 years
People
304 worldwide
Run by
AC Immune SA
See details and how to joinNCT05462106 · EU 2022-500069-29-00
Phase 2Taking people
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Where
Nashville
Age
18 years to 55 years
People
30
Run by
Vanderbilt University Medical Center
See details and how to joinNCT05231798
No phaseTaking people
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
Where
East Lansing
Age
2 years to 7 years
People
30
Run by
Michigan State University
See details and how to joinNCT06951516
No phaseTaking people
Collaboration for Down Syndrome Progress (CDP)
Where
Aurora, Baltimore, Chapel Hill, Houston, Kansas City, Madison, Memphis, Miami, Minneapolis, Orange, Philadelphia, Pittsburgh, San Antonio, Seattle, St Louis
People
1,400
Run by
RTI International
See details and how to joinNCT07625579
No phaseTaking people
Drumming Lessons' Influence on Children With Down Syndrome
Where
Nashville
Age
7 years to 15 years
People
30
Run by
Vanderbilt University
See details and how to joinNCT07156318
No phaseTaking people
Trial-Ready Cohort-Down Syndrome (TRC-DS)
Where
Aurora, Beachwood, Boston, Cincinnati, Indianapolis, Kansas City, Las Vegas, Lexington, Madison, Nashville, Orange, Park Ridge, Phoenix, Pittsburgh, Portland, San Antonio, Staten Island, St Louis
Age
25 years to 55 years
People
550 worldwide
Run by
University of Southern California
See details and how to joinNCT04165109
No phaseTaking people
Patterns of Neurodevelopmental Disorders
Where
Phoenix
People
1,000
Run by
Richard Frye
See details and how to joinNCT06213090
No phaseTaking people
Gamma Frequency Stimulation in Individuals With Down Syndrome
Where
Cambridge
Age
25 years to 65 years
People
60
Run by
Massachusetts Institute of Technology
See details and how to joinNCT05196984
No phaseTaking people
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
Where
The Woodlands
Age
4 years to 12 years
People
100
Run by
Healing Hope International
See details and how to joinNCT07493096
No phaseTaking people
Sleep Intervention and Quality of Life in Down Syndrome
Where
Birmingham
Age
12 months to 30 years
People
20
Run by
University of Alabama at Birmingham
See details and how to joinNCT06783725
No phaseTaking people
Brain Outcomes With Lifestyle Change in Down Syndrome
Where
Kansas City
Age
18 years to 64 years
People
81
Run by
University of Kansas Medical Center
See details and how to joinNCT05985486
No phaseTaking people
Physical Activity and Community EmPOWERment Project
Where
Chapel Hill, Fayetteville
Age
18 years and over
People
376
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT06740162
No phaseTaking people
Retinal Imaging in Neurodegenerative Disease
Where
Durham
Age
18 years and over
People
2,000
Run by
Duke University
See details and how to joinNCT03233646
Phase 3Taking people
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
Where
Asheville, Atlanta, Canton, Chattanooga, Cumming, Douglasville, Johnson City, Knoxville, Lawrenceville, Marietta, Snellville
Age
8 years and over
People
225
Run by
Woolfson Eye Institute
See details and how to joinNCT07135167
No phaseTaking people
Comparison of a Demand Oxygen Delivery
Where
Cincinnati
Age
5 years to 17 years
People
10
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT06609694
Phase 1Enrolling by invitation
Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities
Where
Chicago, Cincinnati, Sacramento
Age
6 years to 24 years
People
68
Run by
University of California, Davis
See details and how to joinNCT05301361
No phaseEnrolling by invitation
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
Where
Ann Arbor
Age
3 years to 23 years
People
40
Run by
University of Michigan
See details and how to joinNCT06614582
No phaseTaking people
The Human Trisome Project
Where
Denver
Age
6 months to 89 years
People
2,500
Run by
University of Colorado, Denver
See details and how to joinNCT02864108
No phaseTaking people
Measuring Aided Language Development
Where
Orlando
Age
42 months to 60 months
People
60
Run by
University of Central Florida
See details and how to joinNCT06512168
No phaseTaking people
Pediatric Down Syndrome Post-Approval Study
Where
Cleveland, Houston, Orange, Phoenix, Queens, Tampa
Age
13 years to 18 years
People
60
Run by
Inspire Medical Systems, Inc.
See details and how to joinNCT06851338
No phaseTaking people
DS-Connect®: The Down Syndrome Registry
Where
Aurora
People
100,000
Run by
University of Colorado, Denver
See details and how to joinNCT01950624