Epilepsy trials in United States

In United States 208 Also abroad 452

208 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Early phase 1Taking people
Pharmacological Modulation of Brain Oscillations in Memory Processing
Where
Dallas
Age
18 years to 55 years
People
60
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT05594017
No phaseTaking people
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Where
Minneapolis, Rochester
Age
18 years and over
People
16
Run by
Mayo Clinic
See details and how to joinNCT06038929
Phase 2Taking people
RENAISSANCE 2: SPN-817 Phase 2, Double-Blind, Placebo-Controlled Study in Adults With Focal Onset Seizures
Where
Albany, Amherst, Asheville, Baltimore, Bethesda, Charlotte, Cleveland, Covington, Detroit, El Paso, Frisco, Gulf Breeze, Hackensack, Houston, Kissimmee, Little Rock, Los Angeles, Louisville, McLean, Miami, Mission Hills, Nashville, Neptune City, New Haven, New Orleans, New York, Orange, Orlando, Philadelphia, Phoenix, Port Charlotte, Port Saint Lucie, Rochester, Springfield, Tucson, West Hills
Age
18 years to 70 years
People
216 worldwide
Run by
Supernus Pharmaceuticals, Inc.
See details and how to joinNCT06798896
Early phase 1Not yet taking people in United States
Cholinergic Enhancement of Theta
Where
Dallas
Age
18 years to 75 years
People
50
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07228338
Phase 2Taking people
A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related Disorders
Where
San Diego
Age
2 years to 60 years
People
20
Run by
Scripps Translational Science Institute
See details and how to joinNCT07847918
No phaseTaking people
Modulating Movement Intention Via Cortical Stimulation
Where
New York
Age
18 years to 65 years
People
30
Run by
NYU Langone Health
See details and how to joinNCT03233399
Early phase 1Taking people
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
Where
Jacksonville, Rochester, Scottsdale
Age
18 years to 75 years
People
12
Run by
Mayo Clinic
See details and how to joinNCT07012148
No phaseTaking people
Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy
Where
Gainesville
Age
Up to 50 years
People
400
Run by
University of Florida
See details and how to joinNCT02216500
No phaseEnrolling by invitation
Neuronal Mechanisms of Human Episodic Memory
Where
Los Angeles
Age
13 years and over
People
200
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT04500119
Early phase 1Not yet taking people in United States
Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring
Where
Minneapolis
Age
18 years and over
People
15
Run by
Adraxe Corp.
See details and how to joinNCT07821697
No phaseEnrolling by invitation
Neural Mechanisms of Social Attribution From Faces
Where
Los Angeles, Palo Alto
Age
18 years and over
People
100
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT07822178
No phaseEnrolling by invitation
RNS System for Drug-Resistant Focal Epilepsy in Adolescents: A Real-World Study
Where
Waltham
Age
13 years to 19 years
People
100
Run by
NeuroPace
See details and how to joinNCT07823465
Phase 1/2Taking people
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
Where
Boston, Charlottesville, Palo Alto
Age
18 years and over
People
8
Run by
NaviFUS Corporation
See details and how to joinNCT06388707
Phase 4Not yet taking people in United States
Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures
Where
Memphis, Winston-Salem
Age
1 month to 17 years
People
40
Run by
Azurity Pharmaceuticals
See details and how to joinNCT06534502
No phaseEnrolling by invitation
Neuronal Mechanisms of Learning and Utilizing Abstract Representations
Where
Los Angeles
Age
18 years and over
People
114
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT07454785
No phaseTaking people
Prospective Natural History Study of POLG Disease
Where
Akron, Aurora, Dallas, Houston, New York, Philadelphia, San Diego
People
300 worldwide
Run by
The POLG Foundation
See details and how to joinNCT07775872
No phaseTaking people
SeizEAR Safety Study
Where
New York
Age
18 years to 70 years
People
15
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07088835
No phaseNot yet taking people in United States
EASEE® System Pivotal Study for the United States of America
Where
New York
Age
18 years to 75 years
People
200
Run by
Precisis US, Inc.
See details and how to joinNCT07301346
No phaseNot yet taking people in United States
Epileptiform Potential of Fully Immersive Virtual Reality
Where
Lebanon
Age
13 years and over
People
40
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT07451093
No phaseTaking people
Physiological Brain Atlas Development
Where
Nashville
Age
6 years to 90 years
People
5,000
Run by
Vanderbilt University Medical Center
See details and how to joinNCT00575081
No phaseTaking people
Retraining and Control Therapy (ReACT): Sense of Control and Symptom Expectations as Targets of a Treatment for PNES
Where
Birmingham
Age
11 years to 18 years
People
68
Run by
University of Alabama at Birmingham
See details and how to joinNCT05096273
Phase 1/2Taking people
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Where
Austin, Baltimore, Bethesda, Birmingham, Boston, Cleveland, Columbus, Grand Rapids, Hackensack, Jacksonville, Kansas City, Lebanon, Milwaukee, New Brunswick, Palo Alto, Philadelphia, Phoenix, Pittsburgh
Age
18 years to 75 years
People
12
Run by
UniQure Biopharma B.V.
See details and how to joinNCT06063850
No phaseEnrolling by invitation
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Where
Nashville, Pasadena
Age
18 years and over
People
1,000
Run by
Peerbridge Health, Inc
See details and how to joinNCT07775976
No phaseTaking people
A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders
Where
Bethesda
Age
1 month to 100 years
People
999
Run by
National Human Genome Research Institute (NHGRI)
See details and how to joinNCT06092346
No phaseEnrolling by invitation
Causal Role of Top-Down Theta Oscillations in Prioritization
Where
Chapel Hill
Age
18 years to 80 years
People
50
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT06252532