Epilepsy trials in United States

In United States 208 Also abroad 452

208 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseEnrolling by invitation
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
Where
Great Neck
Age
5 years and over
People
450
Run by
Northwell Health
See details and how to joinNCT00859794
No phaseTaking people
Surgery as a Treatment for Medically Intractable Epilepsy
Where
Bethesda
Age
8 years to 99 years
People
300
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT01273129
No phaseTaking people
Investigating Epilepsy: Screening and Evaluation
Where
Bethesda
Age
8 years to 110 years
People
1,000
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT03478852
No phaseTaking people
Optimizing Brain Stimulation Parameters
Where
Rochester
Age
6 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT06617845
No phaseTaking people
Diagnosing Epilepsy To EffeCT Change
Where
Ann Arbor, Billings, Birmingham, Boston, Charlotte, Clevland, Dallas, Durham, Houston, Indianapolis, Irvine, Jacksonville, Miami, Minneapolis, New Haven, Palo Alto, Philadelphia, Phoenix, Rochester, San Diego, St Louis, Tampa
Age
18 years to 75 years
People
210
Run by
Epiminder America, Inc.
See details and how to joinNCT07110337
Phase 1/2Taking people
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Where
Ann Arbor, Aurora, Chicago, Columbus, Durham, Fort Worth, Miami, New York, Portland, Rochester, San Francisco
Age
6 months to 17 years
People
113 worldwide
Run by
Encoded Therapeutics
See details and how to joinNCT05419492
No phaseTaking people
Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up
Where
Ann Arbor, Billings, Birmingham, Boston, Charlotte, Cleveland, Durham, Indianapolis, Jacksonville, Miami, Minneapolis, New Haven, Palo Alto, Philadelphia, Phoenix, Rochester, San Diego, St Louis, Tampa
Age
18 years to 75 years
People
210
Run by
Epiminder America, Inc.
See details and how to joinNCT07110454
Phase 4Not yet taking people in United States
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS
Where
Fresno, New Orleans, Raleigh
Age
18 years and over
People
40
Run by
Jazz Pharmaceuticals
See details and how to joinNCT07728097
No phaseTaking people
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
Where
Boston
Age
18 years and over
People
240
Run by
Brigham and Women's Hospital
See details and how to joinNCT07883720
No phaseTaking people
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Where
Bethesda
Age
8 years to 120 years
People
700
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT02107989
Phase 1/2Enrolling by invitation
Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Where
Baltimore
Age
18 years and over
People
22
Run by
Johns Hopkins University
See details and how to joinNCT06369571
No phaseTaking people
Sleep-Sensitive Seizure Risk Assessment With Wearable EEGs
Where
Durham
Age
18 years and over
People
35
Run by
Duke University
See details and how to joinNCT06545643
No phaseTaking people
Artificial Intelligence for Brain MRI Analysis in Epilepsy
Where
Bethesda, Charleston, Chicago, Oakland, Philadelphia, Washington D.C.
People
2,000 worldwide
Run by
Istituto Giannina Gaslini
See details and how to joinNCT07881185
Early phase 1Taking people
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Where
Minneapolis
Age
18 years and over
People
30
Run by
University of Minnesota
See details and how to joinNCT05493722
No phaseTaking people
Overnight TI in TLE
Where
Durham
Age
18 years to 70 years
People
20
Run by
Duke University
See details and how to joinNCT07434986
No phaseTaking people
Post-Market Real-World Evidence Registry for the NeuroOne OneRF® Ablation System for Epilepsy
Where
Livingston, Miami, New Brunswick
People
100
Run by
NeuroOne Medical Technologies Corporation
See details and how to joinNCT07546253
Phase 2Taking people
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric and Young Adult Participants With KCNT1-related Epilepsy
Where
Hackensack, Rochester
Age
1 month to 21 years
People
61
Run by
Actio Biosciences, Inc.
See details and how to joinNCT07600736
No phaseTaking people
Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring
Where
Durham
Age
18 years and over
People
30
Run by
Duke University
See details and how to joinNCT07764718
No phaseTaking people
Ear-Seizure Detection (EarSD) Study
Where
Worcester
Age
18 years and over
People
40
Run by
Felicia Chu
See details and how to joinNCT06598189
Phase 3Enrolling by invitation
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
Where
Aurora, Austin, Bethesda, Boise, Boston, Gulf Breeze, Houston, Iowa City, Little Rock, Livingston, Los Angeles, Miami, Morristown, New York, Orlando, Palo Alto, Portland, Rochester, San Francisco, Tampa
Age
2 years to 66 years
People
324 worldwide
Run by
Longboard Pharmaceuticals
See details and how to joinNCT06908226 · EU 2024-514974-39-00
No phaseTaking people
Clinical and Electrographic Changes in Responsive Neurostimulation System (RNS) Patients With Acupuncture Treatment
Where
Houston
Age
15 years to 60 years
People
10
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT04677751
Phase 1/2Taking people
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Where
Boston, Columbus, Orange, Philadelphia, Rochester
Age
2 years to 12 years
People
20 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT07227857 · EU 2024-513332-17-00
Phase 3Taking people
An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome
Where
Charlotte, Chicago, Dallas, Detroit, Durham, Houston, Little Rock, Louisville, Marlboro, Miami, Morrisville, New York, Omaha, Orange, Orlando, Philadelphia, Roseville, Salt Lake City, Winter Park
Age
2 years to 55 years
People
260 worldwide
Run by
Epygenix
See details and how to joinNCT05066217
No phaseEnrolling by invitation
Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGS
Where
Austin, Louisville, Tacoma
Age
3 years and over
People
20
Run by
Byteflies
See details and how to joinNCT07225231
No phaseTaking people
Pediatric Epilepsy
Where
Dallas
Age
3 years to 25 years
People
200
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07350551