Heart failure trials in United States

In United States 386 Also abroad 1261

386 trials · From ClinicalTrials.gov, checked 10 Nov 2026. Ask the study team whether a trial fits you.

No phaseEnrolling by invitationResearch participation
Global Utilization And Registry Database for Improved heArt preservatioN
Where
Boston, Cincinnati, Dallas, Durham, Fort Wayne, Gainesville, Grand Rapids, Jacksonville, Lawrence, Memphis, New York, Norfolk, Orlando, Stanford, State College, Washington D.C.
People
4,000 worldwide
Run by
Paragonix Technologies
See details and how to joinNCT04141605Registry updated 2026-10-16
No phaseRecruitingResearch participation
The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
Where
Ann Arbor, Austin, Charleston, Charlottesville, Cleveland, Hershey, Jonesboro, Kansas City, Mesa, Naples, New York, Scottsdale
Age
22 years and over
People
320
Run by
EBR Systems, Inc.
See details and how to joinNCT07098858Registry updated 2026-10-16
Phase 4Enrolling by invitationTrial-stage medicine
Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF)
Where
Pleasanton
Age
60 years and over
People
240
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07298993Registry updated 2026-10-16
No phaseRecruitingResearch participation
NORM-HF Pivotal Study
Where
Baton Rouge, Boston, Chapel Hill, Chula Vista, Cincinnati, Colombus, Columbia, Dallas, Greenville, Jacksonville, Kansas City, New York, Omaha, Philadelphia, Plano, Round Rock, Sacramento, Sioux Falls, Tampa, Temple, Toledo, Tulsa
Age
18 years and over
People
800
Run by
Foundry Innovation & Research 1, Limited (FIRE1)
See details and how to joinNCT07574593Registry updated 2026-10-16
No phaseRecruitingResearch participation
Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction
Where
Norfolk
Age
18 years to 85 years
People
40
Run by
Old Dominion University
See details and how to joinNCT07644806Registry updated 2026-10-16
Phase 1RecruitingTrial-stage medicine
Resmetirom in Patients With MASH and HFpEF
Where
Fort Myers, Oxnard, Peoria, Riverview, University Park
Age
18 years and over
People
90
Run by
Madrigal Pharmaceuticals, Inc.
See details and how to joinNCT07830758Registry updated 2026-10-16
No phaseNot yet recruitingResearch participation
Inspiratory Muscle Training in Hospitalized Patients With Heart Failure Awaiting Advanced Therapies
Where
New York
Age
18 years and over
People
30
Run by
NYU Langone Health
See details and how to joinNCT07862738Registry updated 2026-10-16
Phase 3RecruitingTrial-stage medicine
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Ann Arbor, Atlanta, Aurora, Boston, Cincinnati, Cleveland, Columbus, Dallas, Gainesville, Hollywood, Houston, Indianapolis, Kansas City, New York, North Charleston, Philadelphia, Pittsburgh, Salt Lake City, St Louis, The Bronx, Wilmington
Age
6 months to 17 years
People
111 worldwide
Run by
Bayer
See details and how to joinNCT07188805EU 2024-519829-38-00Registry updated 2026-10-15
Phase 4RecruitingTrial-stage medicine
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
Where
Ann Arbor
Age
18 years and over
People
100
Run by
University of Michigan
See details and how to joinNCT07490067Registry updated 2026-10-15
Phase 4Not yet recruitingTrial-stage medicine
IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency
Where
Durham
Age
65 years and over
People
300
Run by
Duke University
See details and how to joinNCT07686692Registry updated 2026-10-15
Phase 2RecruitingTrial-stage medicine
Dose-finding Study of YMI024 to Assess Efficacy, Safety, and Tolerability in Adults With Stable Coronary Artery Disease and Elevated hsCRP
Where
Amarillo, Coral Gables, Fairhope, Foley, Ft. Washington, Los Angeles, Oxon Hill, Wichita, Winchester
Age
18 years to 80 years
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07830719EU 2026-525974-21-00Registry updated 2026-10-15
No phaseRecruitingResearch participation
Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure
Where
Baltimore, Hagerstown
Age
30 years to 70 years
People
156
Run by
Johns Hopkins University
See details and how to joinNCT06364644Registry updated 2026-10-14
Phase 2Enrolling by invitationResearch participation
Chronic Exogenous Ketosis in HFpEF
Where
Durham
Age
18 years and over
People
20
Run by
Duke University
See details and how to joinNCT06937320Registry updated 2026-10-14
No phaseRecruitingResearch participation
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Where
Oklahoma City
Age
18 years to 80 years
People
100
Run by
University of Oklahoma
See details and how to joinNCT02898181Registry updated 2026-10-13
No phaseRecruitingResearch participation
Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer
Where
New York
Age
18 years and over
People
60
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06228209Registry updated 2026-10-13
Phase 3RecruitingResearch participation
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Abington, Albany, Alexander City, Alexandria, Allen, Altamonte Springs, Amarillo, Anderson, Ann Arbor, Asheville, Atlanta, Augusta, Aurora, Beverly Hills, Birmingham, Bloomfield Hills, Boca Raton, Boston, Bradenton, Bridgewater, Brooklyn, Camp Hill, Chapel Hill, Charleston, Charlotte, Chicago, Cincinnati, Clearwater, Clifton Park, Columbia, Covina, Cypress, Dallas, Dayton, Dearborn, Delray Beach, Durham, Elkhart, El Paso, Encinitas, Evansville, Fairhope, Fall River, Falls Church, Farmington Hills, Flint, Fort Lauderdale, Gainesville, Glenview, Greensboro, Hammond, Hazel Crest, Henderson, Hershey, Horsham, Houston, Huntsville, Indianapolis, Jackson, Jacksonville, Jersey City, Kansas City, Katy, Knoxville, Ladson, Lancaster, Lincoln, Little Rock, Los Angeles, Louisville, Manhasset, Mansfield, Maumee, McKinney, Memphis, Miami, Miami Lakes, Minneapolis, Muncie, Munster, Nashville, New Orleans, Newport Beach, Newport News, New Windsor, New York, North Chicago, North Las Vegas, Odessa, Oklahoma City, Orange, Palm Beach Gardens, Peachtree City, Pearland, Pensacola, Peoria, Philadelphia, Phoenix, Pinehurst, Port Charlotte, Portland, Providence, Puyallup, Rapid City, Redding, Richmond, Rockville, Safety Harbor, Saint Augustine, Saint Paul, Salt Lake City, San Antonio, San Diego, San Francisco, Santa Ana, Seattle, Sherman, Shreveport, Somerset, Springfield, Staten Island, Statesville, Stony Brook, St. Petersburg, Tacoma, Tampa, Temple, The Bronx, Thomasville, Thousand Oaks, Troy, Tucker, Tullahoma, Tyler, Vista, Waterloo, West Hills, West Monroe, Wheat Ridge, Wichita, Wilmington, Winfield, Worcester, Ypsilanti
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652EU 2023-508162-15-00Registry updated 2026-10-13
No phaseRecruitingTrial-stage medicine
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Where
Ann Arbor, Atlanta, Augusta, Cincinnati, Cleveland, Columbus, Dallas, Durham, Falls Church, Gainesville, Grand Rapids, Greensboro, Greenville, Houston, Irvine, Jackson, Kansas City, Long Beach, Louisville, Milwaukee, Minneapolis, Nashville, Oak Lawn, Oklahoma City, Philadelphia, Richmond, Royal Oak, Sacramento, St Louis, Winston-Salem
Age
22 years and over
People
400 worldwide
Run by
Reprieve Cardiovascular, Inc
See details and how to joinNCT06898515Registry updated 2026-10-13
No phaseRecruitingResearch participation
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
Where
Charlotte, Dallas, Durham, Hackensack, Indianapolis, Minneapolis, Nashville, New Brunswick, New York, Philadelphia, Pittsburgh, Salt Lake City, St Louis, Tampa, Valhalla, Winston-Salem
Age
18 years to 80 years
People
250
Run by
Abiomed Inc.
See details and how to joinNCT06965504Registry updated 2026-10-13
Phase 4RecruitingTrial-stage medicine
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
Where
Detroit
Age
18 years and over
People
200
Run by
VA Office of Research and Development
See details and how to joinNCT07210606Registry updated 2026-10-13
Phase 2RecruitingTrial-stage medicine
A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
Where
Baltimore, Beverly Hills, Birmingham, Charleston, Charlottesville, Cincinnati, Dallas, Fort Wayne, Gainesville, Greensboro, Houma, Houston, Indianapolis, Jackson, Kansas City, Little Rock, Mechanicsburg, Minneapolis, New York, Peoria, San Diego, Seattle, St Louis, Tulsa, Vista, Ypsilanti
Age
30 years to 84 years
People
90
Run by
Edgewise Therapeutics, Inc.
See details and how to joinNCT07795814Registry updated 2026-10-13
No phaseRecruitingResearch participation
Technical Development of Cardiovascular Magnetic Resonance Imaging
Where
Bethesda, Washington D.C.
Age
18 years to 100 years
People
3,400
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT04927429Registry updated 2026-10-09
No phaseNot yet recruitingTrial-stage medicine
A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation.
Where
Birmingham, Boston, Burlington, Charleston, Charlottesville, Cleveland, Columbus, Delray Beach, Glenview, Hackensack, Houma, Houston, Indianapolis, Kansas City, Largo, Manhasset, Minneapolis, Murray, Norfolk, Phoenix, Plano, Portland, Roanoke, Sacramento, San Diego, San Francisco, San Jose, St Louis, Tampa, The Bronx, Washington D.C.
Age
18 years to 85 years
People
780
Run by
P+F Products + Features USA Inc.
See details and how to joinNCT06458907Registry updated 2026-10-09
Phase 1RecruitingTrial-stage medicine
Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure
Where
New York
Age
18 years and over
People
40
Run by
Melana Yuzefpolskaya, MD
See details and how to joinNCT07490054Registry updated 2026-10-08
No phaseRecruitingResearch participation
CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)
Where
Ann Arbor, Birmingham, Cleveland, Dallas, Decatur, Gainesville, Hines, Houston, Little Rock, Long Beach, Louisville, Madison, Minneapolis, Nashville, New York, Palo Alto, Portland, Richmond, Salt Lake City, Washington D.C., West Los Angeles
Age
60 years and over
People
1,400
Run by
VA Office of Research and Development
See details and how to joinNCT05996328Registry updated 2026-10-07
No phaseRecruitingResearch participation
Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation
Where
Cleveland, Detroit, Philadelphia, Salt Lake City
Age
18 years and over
People
100
Run by
University of Pennsylvania
See details and how to joinNCT06291922Registry updated 2026-10-07

All Heart failure trials and the map

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