Huntington's disease trials in United States

In United States 21 Also abroad 51

21 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease
Where
Boston, Charlestown, Columbus, Englewood
Age
25 years and over
People
400 worldwide
Run by
Skyhawk Therapeutics, Inc.
See details and how to joinNCT07378644 · EU 2025-522263-14-00
Phase 3Taking people
Pridopidine Phase 3 Study in Huntington's Disease
Where
Baltimore, Birmingham, Boca Raton, Burlington, Charlestown, Chicago, Cincinnati, Cleveland, Columbus, Durham, Gainesville, Golden Valley, Houston, Kansas City, Kirkland, La Jolla, Los Angeles, Nashville, New York, Portland, Sacramento, Seattle, Washington D.C., Wichita
Age
23 years to 65 years
People
400 worldwide
Run by
Prilenia
See details and how to joinNCT07609108 · EU 2026-526093-16-00
No phaseTaking people
Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study
Where
Ann Arbor
Age
18 years and over
People
60
Run by
University of Michigan
See details and how to joinNCT07280650
No phaseNot yet taking people in United States
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease
Where
Nashville, Rochester
Age
25 years to 65 years
People
75
Run by
BioSensics
See details and how to joinNCT07315984
Phase 3Taking people
A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease
Where
Albany, Atlanta, Baltimore, Birmingham, Boston, Buffalo, Burlington, Chapel Hill, Chicago, Cleveland, Detroit, Durham, Englewood, Fairway, Farmington, Georgetown, Grand Rapids, Houston, Indianapolis, Iowa City, La Jolla, Little Rock, Madison, Memphis, Miami, Nashville, New York, Philadelphia, Pittsburgh, Portland, Richmond, Rochester, Sacramento, San Francisco, Seattle, Stanford, Tampa, Washington D.C., Wichita
Age
21 years to 70 years
People
770 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07326709 · EU 2025-522227-99-00
No phaseTaking people
Digital Measures for Clinical Trial Endpoints in Huntington's Disease
Where
Rochester
Age
25 years to 65 years
People
100
Run by
University of Rochester
See details and how to joinNCT07010705
Phase 1/2Taking people
A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Where
Boston, Cincinnati, Columbus, Philadelphia, Pittsburgh
Age
25 years to 65 years
People
53
Run by
Hoffmann-La Roche
See details and how to joinNCT06826612
No phaseTaking people
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
Where
Baltimore, Englewood, Houston, Nashville, Washington D.C., Winston-Salem
Age
11 years to 75 years
People
2,500 worldwide
Run by
University College, London
See details and how to joinNCT02855476
Phase 1/2Taking people
Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease
Where
Irvine
Age
18 years to 65 years
People
21
Run by
Leslie Thompson
See details and how to joinNCT07451613
No phaseTaking people
Cognitive Assessment Tools for Huntington's Disease.
Where
Columbus
Age
30 years to 65 years
People
76
Run by
Ohio State University
See details and how to joinNCT06546488
No phaseTaking people
Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease
Where
Houston
Age
18 years to 80 years
People
10
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT05326451
No phaseTaking people
Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease
Where
San Antonio
Age
18 years to 85 years
People
16
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT06843252
No phaseTaking people
Retinal Imaging in Neurodegenerative Disease
Where
Durham
Age
18 years and over
People
2,000
Run by
Duke University
See details and how to joinNCT03233646
No phaseTaking people
Social Cognition Training in Individuals With Huntington's Disease
Where
Chicago
Age
18 years to 65 years
People
20
Run by
Rush University Medical Center
See details and how to joinNCT06828471
No phaseTaking people
Longitudinal Endpoint Assessment of Disease Burden in HD
Where
Rochester
Age
18 years and over
People
600
Run by
Huntington Study Group
See details and how to joinNCT06475898
No phaseTaking people
Gut Microbiomes in HD
Where
Orlando
Age
18 years and over
People
36
Run by
University of Central Florida
See details and how to joinNCT06448546
No phaseTaking people
Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping
Where
Palo Alto
People
200
Run by
Stanford University
See details and how to joinNCT06941662
No phaseTaking people
University of Central Florida CereBank
Where
Orlando
Age
18 years and over
People
50,000
Run by
University of Central Florida
See details and how to joinNCT06876857
No phaseTaking people
NYSCF Scientific Discovery Biobank
Where
New York
Age
30 days and over
People
10,000
Run by
New York Stem Cell Foundation Research Institute
See details and how to joinNCT06203106
No phaseTaking people
Extracellular Vesicles for HD
Where
Orlando
Age
18 years to 75 years
People
100
Run by
University of Central Florida
See details and how to joinNCT06082713
No phaseTaking people
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
Where
Albany, Ann Arbor, Atlanta, Augusta, Baltimore, Birmingham, Boston, Burlington, Camden, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Columbus, Detroit, Durham, Englewood, Fargo, Farmington, Gainesville, Henrico, Houston, Indianapolis, Iowa City, Irvine, Kansas City, Kirkland, Las Vegas, Loma Linda, Los Angeles, Louisville, Madison, Memphis, Miami, Minneapolis, Nashville, New Brunswick, New York, Omaha, Philadelphia, Phoenix, Pittsburgh, Portland, Richmond, Rochester, Rockford, Sacramento, Salt Lake City, San Diego, San Francisco, Seattle, St Louis, Tampa, Washington D.C., Wichita, Winston-Salem
Age
18 years and over
People
35,000 worldwide
Run by
CHDI Foundation, Inc.
See details and how to joinNCT01574053