Long COVID and ME/CFS: open trials in United States

68 open trials have a site in United States. Registry data; only the trial team decides who can take part.

NCT07388550
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Trial Treatment · Phase 1 · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-06
NCT07916259
The Study of Brave-LC LDN Treatment Trial
Trial Treatment · Phase 3 · National Institute of Allergy and Infectious Diseases (NIAID)
Kennedy Krieger Institute, Baltimore · Children's of Alabama Child Health Research Unit (CHRU), Birmingham · Brigham and Women's Hospital, Boston · NYU Langone Hospital - Brooklyn, Brooklyn · Rush University Medical Center, Chicago · Exalt Clinical Research Inc, Chula Vista · Denver Health, Denver · University of Florida Health, Gainesville · Baylor College of Medicine, Houston · Dartmouth Health, Lebanon · Rutgers, Robert Wood Johnson Medical School, New Brunswick · Columbia University, New York · University of Massachusetts Chan Medical School, Worcester
Registry updated 2026-11-04
NCT05350774
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Trial Treatment · Phase 2 · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-11-03
NCT07523113
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
Trial Treatment · University of Alabama at Birmingham
University of Alabama at Birmingham, Birmingham
Registry updated 2026-10-29
NCT07597902
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
Trial Treatment · Phase 2 · Icahn School of Medicine at Mount Sinai
The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York
Registry updated 2026-10-28
NCT07600320
Fareon Open Label Device Clinical Trial
Trial Treatment · Icahn School of Medicine at Mount Sinai
The Cohen Center for Recovery from Complex Chronic Illnesses (CoRE), New York
Registry updated 2026-10-28
NCT06366724
LIFT: Life Improvement Trial
Trial Treatment · Phase 2 · Brigham and Women's Hospital
Brigham and Women's Hospital, Boston
Registry updated 2026-10-15
NCT07285473
Low-Dose Naltrexone For ME/CFS: Dose-Finding
Trial Treatment · Phase 2 · University of Alabama at Birmingham
University of Alabama at Birmingham, Birmingham
Registry updated 2026-10-08
NCT06928272
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
Trial Treatment · Phase 3 · Douglas D. Fraser
Laura Rodriguez Research Institute, San Diego
Registry updated 2026-10-06
NCT07856121
The Precision Mito- Mito Map COMPASS Study
Research · AI Agent Vault, Inc. d/b/a Precision Mito
Precision Mito, Fort Myers
Registry updated 2026-10-02
NCT07021794
SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
Trial Treatment · Phase 2 · Nancy Klimas
Nova Southeastern University, Fort Lauderdale
Registry updated 2026-09-29
NCT06928116
Heat thErapy And mobiLity in COVID-19 Survivors
Trial Treatment · University of Nebraska
University of Nebraska Omaha, Omaha
Registry updated 2026-09-28
NCT07781501
Long-Term Study of COVID-19 Infection and Long COVID
Research · University of North Carolina, Chapel Hill
University of North Carolina, Chapel Hill
Registry updated 2026-09-28
NCT06631287
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
Trial Treatment · Phase 3 · Wes Ely
Emory University, Atlanta · University of Colorado I Anschutz Medical Campus, Aurora · Brigham and Women's Hospital, Boston · NYU Langone Health - Brooklyn, Brooklyn · Illinois Research Network (ILLInet), University of Illinois Chicago, Chicago · The MetroHealth System, Cleveland · University Hospitals Cleveland Case Western, Cleveland · University of Florida College of Medicine, Gainesville · University of California Los Angeles (UCLA)., Los Angeles · University of Minnesota, Minneapolis · West Virginia Clinical and Translational Science Institute, Morgantown · Vanderbilt University Medical, Nashville · Yale University, New Haven · University of Texas at San Antonio, San Antonio · University of California San Francisco, San Francisco · Swedish Medical Center, Seattle · University of Arizona, Tucson
Registry updated 2026-09-25
NCT07123727
A Study to Examine Anktiva for the Treatment of COVID-19.
Trial Treatment · Phase 2 · ImmunityBio, Inc.
Chan Soon-Schiong Institute for Medicine (CSSIFM), El Segundo
Registry updated 2026-09-24
NCT06577467
Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
Research · National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-09-16
NCT07140094
Long-Covid-19 Alleviation Through Learning Mindfulness Study
Trial Treatment · Columbia University
Columbia University, New York
Registry updated 2026-08-31
NCT06865222
Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation
Trial Treatment · Mayo Clinic
Mayo Clinic in Rochester, Rochester
Registry updated 2026-08-19
NCT06920628
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Trial Treatment · Phase 1 · National Institute of Mental Health (NIMH)
National Institutes of Health Clinical Center, Bethesda
Registry updated 2026-08-18
NCT07770022
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
Research · University of California, San Francisco
Zuckerberg San Francisco General Hospital, San Francisco
Registry updated 2026-08-18
NCT07753122
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Trial Treatment · Fred Friedberg
Stony Brook University, Stony Brook
Registry updated 2026-08-07
NCT05373043
Long-term COVID and Rehabilitation
Trial Treatment · VA Office of Research and Development
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
Registry updated 2026-07-30
NCT04362150
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
Research · University of California, San Francisco
Zuckerberg San Francisco General Hospital (ZSFG), San Francisco
Registry updated 2026-07-23
NCT06086379
Cognitive Rehabilitation Therapy for COVID-19
Trial Treatment · VA Office of Research and Development
VA San Diego Healthcare System, San Diego, CA, San Diego
Registry updated 2026-07-15
NCT06940609
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
Trial Treatment · Phase 2 · University of New Mexico
University of New Mexico Health Science Center, Albuquerque
Registry updated 2026-07-15

All Long COVID and ME/CFS trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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