Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors
Where
Austin, Cincinnati, Dallas, Detroit, Englewood, Fairfax, Fairway, Houston, La Jolla, Lake Success, Laredo, Los Angeles, Madison, Maple Grove, Nashville, Rochester, San Francisco, Tucson
Age
18 years and over
People
92
Run by
Aminex Therapeutics, Inc.
See details and how to joinNCT07287917
Phase 3Taking people
Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Stanford, Uniondale
Age
18 years and over
People
14,000
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07890415
Phase 1/2Taking people
A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
Where
Atlanta, Austin, Canton, Celebration, Charleston, Cincinnati, Dallas, Dayton, Detroit, Fairfax, Greenville, Las Vegas, Los Angeles, Louisville, Margate, Nashville, New York, Orlando, Plantation, Saint Paul, Santa Monica, Spokane, Tamarac, Tucson
Age
18 years and over
People
862 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT05914116
Phase 1/2Taking people
Intratumoral N17350 in Advanced Solid Tumors
Where
Buffalo, Houston, Los Angeles, San Diego, San Francisco
Age
18 years and over
People
275 worldwide
Run by
Onchilles Pharma Inc
See details and how to joinNCT07339176
Phase 1/2Taking people
Axelopran and Nivolumab in PD-1-Refractory Metastatic Melanoma
Where
Pittsburgh
Age
18 years and over
People
28
Run by
John Kirkwood
See details and how to joinNCT07631325
No phaseTaking people
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
Where
Columbus
People
500
Run by
Mohamed Abdel-Rahman
See details and how to joinNCT04792463
No phaseEnrolling by invitation
Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment
Where
Bethesda
Age
18 years and over
People
1,200
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05600933
No phaseNot yet taking people in United States
Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial
Where
Ann Arbor
Age
20 years to 39 years
People
142
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07529080
Phase 1/2Taking people
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
Where
Atlanta, Aventura, Baltimore, Chicago, City of Saint Peters, Coral Gables, Creve Coeur, Deerfield Beach, La Jolla, Lexington, Los Angeles, Miami, Mineola, New York, North Miami, Pittsburgh, Plantation, Salt Lake City, Shiloh, St Louis, Washington D.C.
Age
18 years and over
People
16
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05896839
Phase 1/2Taking people
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
Where
Chapel Hill, Cleveland, Iowa City, Jacksonville, Lexington, Madison, Miami, Minneapolis, Omaha, Orange, Philadelphia, Pittsburgh, Rochester, Sarasota, St Louis
Age
18 years to 90 years
People
300
Run by
Perspective Therapeutics
See details and how to joinNCT05655312
Phase 1Taking people
A Study of mRNA-4106 or mRNA-4200 Administered Alone or in Combination With Anti-Cancer Agents in Participants With Solid Tumors
Where
Grand Rapids, Los Angeles, San Antonio, West Valley City
Age
18 years and over
People
42
Run by
ModernaTX, Inc.
See details and how to joinNCT06880549
Phase 4Taking people
Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study
Where
Portland
Age
18 years and over
People
160
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT07405086
Phase 1/2Taking people
A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors
Where
Fairfax, Huntersville, New York, San Antonio
Age
18 years and over
People
499
Run by
Arvinas Inc.
See details and how to joinNCT07749586 · EU 2026-525614-57-00
Phase 1/2Taking people
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
Where
Atlanta, Boston, Cleveland, Detroit, Durham, Grand Rapids, Hartford, Houston, Madison, New Haven, New York, Phoenix, Pittsburgh, San Antonio, San Francisco, Sarasota, Tampa, West Valley City
Age
18 years and over
People
1,438 worldwide
Run by
BioNTech SE
See details and how to joinNCT07070232 · EU 2024-517261-16-00
No phaseNot yet taking people in United States
Trial Comparing CPDMA Versus Standard Breadloafing in WLE Specimens of Stage 1-II Cutaneous Melanoma
Where
Omaha
Age
19 years and over
People
282
Run by
University of Nebraska
See details and how to joinNCT07869381
Phase 1/2Taking people
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
Where
Fairfax, Grand Rapids, Houston, Pittsburgh, San Antonio, St Louis
Age
18 years and over
People
120 worldwide
Run by
AstraZeneca
See details and how to joinNCT07115043
No phaseTaking people
Well-Being and Health-Related Quality of Life in Melanoma Patients During COVID-19 Pandemic
Where
Houston
People
1,152
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04474301
Phase 2Taking people
A Study of Fianlimab, Cemiplimab, and Ipilimumab in People With Melanoma
Where
Basking Ridge, Commack, Hackensack, Harrison, Hartford, Houston, Los Angeles, Middletown, Montvale, New York, Stanford, Uniondale
Age
18 years and over
People
88
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06594991
Phase 2Not yet taking people in United States
Neoadjuvant RP2 + Nivolumab in Patients With Melanoma
Where
Pittsburgh
Age
18 years and over
People
34
Run by
Yana Najjar
See details and how to joinNCT07862530
Phase 1Taking people
IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors
Where
Houston
Age
18 years and over
People
54
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05039801
Phase 1Taking people
Phase Ib Study of AlpeliSib With PEmbroLizumab in Patients With mEtastatic Breast caNcer or melanomA (SELENA)
Where
Houston
Age
18 years and over
People
50
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06545682
Phase 2/3Taking people
Safety and Efficacy of EIK1001 in Combo With Pembro Versus Placebo and Pembro as First-Line Therapy in Patients With Advanced Melanoma.
Where
Bethesda, Canton, Chandler, Colorado Springs, Hialeah, Hot Springs, Kansas City, Los Angeles, Newark, Pittsburgh, Santa Rosa, St Louis, Sugar Land, Tamarac
Age
18 years and over
People
740 worldwide
Run by
Eikon Therapeutics
See details and how to joinNCT06697301 · EU 2024-512659-19-00
Phase 1/2Taking people
Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors
Where
Gilbert, Seattle, Tucson
Age
18 years to 99 years
People
30
Run by
University of Arizona
See details and how to joinNCT06814496
Phase 1Taking people
Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel)
Where
Houston
Age
18 years and over
People
39
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06660420
Phase 2Taking people
Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Where
Jacksonville
Age
18 years and over
People
50
Run by
Mayo Clinic
See details and how to joinNCT06265285