Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Where
Atlanta, Austin, East Brunswick, Fairfax, Fort Worth, Grand Rapids, Houston, Lake Success, Nashville, New Haven, Sioux Falls, St Louis, West Valley City, Wilson
Age
18 years and over
People
124 worldwide
Run by
Pliant Therapeutics, Inc.
See details and how to joinNCT06270706
Phase 2Taking people
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Where
Jacksonville
Age
18 years and over
People
27
Run by
Mayo Clinic
See details and how to joinNCT07285044
Phase 2Taking people
NeoAdjuvant, Spare-Adjuvant (NASA) in Stage IIIB-IV (M1a) Melanoma
Where
Chapel Hill
Age
18 years and over
People
55
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT07740941
No phaseTaking people
Prebiotic Food-enriched Diet (PreFED) to Enhance the Microbiome and Response to First-line Immunotherapy in Unresectable Melanoma
Where
Houston
Age
18 years and over
People
75
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06466434
Phase 2Taking people
Neoadjuvant Immune Checkpoint Blockade + a Prebiotic Food-enriched Dietary Intervention to Optimize Immune Response in Melanoma: NEO-PreFED
Where
Houston
Age
18 years and over
People
35
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06548789
No phaseTaking people
DESTINY-PANTUMOUR04
Where
Birmingham, Boulder, Bullhead City, Canton, Casa Grande, Coral Springs, Dallas, Decatur, Durham, Farmington, Maumee, Nashville, Philadelphia, San Diego, St. Petersburg, Topeka, West Palm Beach, Wilson
Age
18 years to 130 years
People
100
Run by
AstraZeneca
See details and how to joinNCT07124000
Phase 3Taking people
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
Where
Aurora, Bartlett, Bethesda, Birmingham, Camden, Chicago, Cincinnati, Columbus, Detroit, Duarte, Easton, Edmonds, Kansas City, Lebanon, Los Angeles, Louisville, Minneapolis, Nashville, Orlando, Pittsburgh, Richmond, Salt Lake City, San Francisco
Age
18 years to 70 years
People
670 worldwide
Run by
Iovance Biotherapeutics, Inc.
See details and how to joinNCT05727904 · EU 2022-503140-41-00
Phase 1/2Taking people
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Where
Beverly Hills, Boston, Boynton Beach, Dallas, Glendale, Los Angeles, Nashville, Tacoma
Age
18 years and over
People
134
Run by
Neonc Technologies, Inc.
See details and how to joinNCT06047379
No phaseTaking people
Pan-tumor MRD Study
Where
Atlanta, Binghamton, Birmingham, Bullhead City, Canton, Casa Grande, Charlotte, Coral Springs, Corbin, Covington, Elizabethtown, Englewood, Farmington, Glendale, Goldsboro, Grand Rapids, Houston, Kingwood, Lancaster, Lexington, Lincoln, Little Rock, Louisville, Maumee, O'Fallon, Orange City, Oxnard, Portland, Richmond, Rochester, San Diego, Sayre, Shirley, Shreveport, Springdale, Springfield, Stockton, St. Petersburg, Tacoma, Texarkana, Topeka, Tulsa, Urbana, Wichita, Wilson, York
Age
18 years and over
People
1,350
Run by
Paradigm Health
See details and how to joinNCT06605404
Phase 3Taking people
Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
Where
Albuquerque, Anaconda, Arroyo Grande, Atlanta, Aurora, Avon, Bardstown, Baton Rouge, Battle Creek, Beachwood, Bemidji, Berlin Corners, Billings, Birmingham, Bismarck, Bozeman, Bridgeport, Buffalo, Burlington, Burr Ridge, Carmichael, Cary, Chadds Ford, Charleston, Charlottesville, Cheyenne, Chicago, Cincinnati, Cleveland, Cody, Coeur d'Alene, Colorado Springs, Columbus, Corbin, Daphne, Durango, Durham, East Norriton, Elk Grove, Elkton, Erie, Evanston, Fairbanks, Fairhope, Fargo, Glens Falls, Glenview, Grand Island, Grand Rapids, Great Falls, Hackensack, Hackettstown, Havre, Helena, Highland Park, Homer Glen, Irvine, Kalamazoo, Kalispell, Kansas City, Kearney, La Jolla, Lake Forest, Lakeland, Lake Mary, Lakewood, Lee's Summit, Lewes, Lexington, Loma Linda, London, Long Branch, Longmont, Los Angeles, Marshfield, Martinsburg, Maywood, Melrose Park, Menomonee Falls, Merced, Millville, Milwaukee, Mineola, Missoula, Mobile, Morgantown, Morristown, Mount Sterling, Muskegon, Nashville, Newark, New Berlin, New Brunswick, Newton, New York, Niles, Norton Shores, Oak Creek, Ocoee, Oklahoma City, Omaha, Orange, Orlando, Orland Park, Overland Park, Paramus, Parkersburg, Patchogue, Philadelphia, Phoenix, Pittsburgh, Pompton, Post Falls, Princeton, Pueblo, Raleigh, Reed City, Rehoboth Beach, Reno, Richmond, Rocklin, Sacramento, Saint Joseph, Sandpoint, San Luis Obispo, Santa Maria, Saraland, Seattle, Silverdale, Stockton, Stony Brook, Summit, The Bronx, Thief River Falls, Toms River, Traverse City, West Bend, Westminster, Weston, Westwood, Willow Grove, Wilmington, Woodland, Wyoming
Age
75 years and over
People
428
Run by
ECOG-ACRIN Cancer Research Group
See details and how to joinNCT07068074
Phase 2Taking people
A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
Where
Austin, Houston, Jacksonville, Knoxville, Memphis, Oakland, Orlando, Pensacola, Philadelphia, Pittsburgh, Salt Lake City, Toledo, Wilmington
Age
Up to 25 years
People
51
Run by
Children's Oncology Group
See details and how to joinNCT07621614
Phase 1Not yet taking people in United States
Adding Anakinra and Tocilizumab to Nivolumab and Ipilimumab for the Treatment of Melanoma Patients 50 Years of Age or Older
Where
Los Angeles
Age
50 years and over
People
40
Run by
University of Southern California
See details and how to joinNCT07838974
No phaseTaking people
Bright Light Therapy in Patients With Melanoma or Non-small Cell Lung Cancer (NSCLC) Who Are Receiving First-Line Immune Checkpoint Blockade
Where
New York
Age
18 years and over
People
12
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07661966
Phase 2Not yet taking people in United States
Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular Cancer
Where
Los Angeles
Age
18 years and over
People
46
Run by
University of Southern California
See details and how to joinNCT07836712
Phase 1Taking people
Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
Where
Columbus, Orlando, St Louis
Age
18 years and over
People
64
Run by
Washington University School of Medicine
See details and how to joinNCT06529822
No phaseTaking people
A Pilot Study of ctDNA-Guided Immune Checkpoint Inhibitor Duration in Patients With Advanced Melanoma.
Where
New Brunswick
Age
18 years to 90 years
People
35
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT07830225
Phase 1Taking people
Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer Patients
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT04038619
Phase 1/2Taking people
BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
Where
Duarte, New York, Philadelphia
Age
18 years and over
People
250 worldwide
Run by
BioInvent International AB
See details and how to joinNCT04752826 · EU 2023-509847-29-00
Phase 1/2Taking people
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
Where
Austin, Grand Rapids, Houston, Huntersville, Miami, Minneapolis, Nashville, Salt Lake City, San Antonio, St Louis
Age
18 years and over
People
159 worldwide
Run by
Aulos Bioscience, Inc.
See details and how to joinNCT05267626
Phase 1Taking people
R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors
Where
Denver, Nashville
Age
18 years to 80 years
People
33
Run by
Rise Therapeutics LLC
See details and how to joinNCT06398418
Early phase 1Taking people
Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma
Where
Tampa
Age
18 years and over
People
50
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT04741997
Phase 3Taking people
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
Where
Albuquerque, Austin, Bend, Beverly, Boston, Bowling Green, Cedar Park, Chapel Hill, Charleston, Chicago, Clark, Cleveland, Coral Springs, Dallas, Delray Beach, Hershey, Houston, Indianapolis, La Jolla, Las Vegas, Lee's Summit, Lewisville, Midland, Naperville, New York, North Little Rock, Oceanside, Oklahoma City, Philadelphia, Phoenix, Portland, Portsmouth, Redwood City, Richmond, Rockville, Salt Lake City, San Antonio, Scottsdale, Springfield, St Louis, Tampa, Troy, Tucson, Victor, Visalia, Washington D.C., Webster
Age
18 years and over
People
369 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06585410
Phase 2Taking people
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Where
Aberdeen, Alton, Ames, Anaconda, Anchorage, Ann Arbor, Antigo, Aurora, Aventura, Baker City, Ballwin, Battle Creek, Beachwood, Beavercreek, Bellingham, Belpre, Bend, Billings, Birmingham, Bloomington, Boardman, Boise, Bolivar, Boone, Boulder, Bozeman, Branson, Brighton, Buffalo, Burbank, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carroll, Carterville, Carthage, Centennial, Centerville, Centralia, Chardon, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clemmons, Cleveland, Clinton, Cody, Coeur d'Alene, Columbus, Coon Rapids, Coos Bay, Coral Gables, Danville, Dayton, Decatur, Deerfield Beach, Delaware, Denver, Des Moines, Dixon, Dublin, Eau Claire, Edina, Edmonds, Effingham, Emeryville, Emmett, Englewood, Eureka, Everett, Fairbanks, Fairhope, Farmington, Findlay, Fort Dodge, Fort Smith, Franklin, Fridley, Fruitland, Gahanna, Galesburg, Garden City, Goldsboro, Grand Rapids, Great Bend, Great Falls, Greeley, Greenville, Grove City, Issaquah, Jacksonville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kennewick, Kettering, Kewanee, Lacey, La Crosse, Lake Forest, Lakewood, Lancaster, Lima, Lincoln, Littleton, Lone Tree, Longview, Los Angeles, Loveland, Macomb, Madison, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marshalltown, Marshfield, Martinez, Medford, Meridian, Miami, Middleburg Heights, Minneapolis, Minocqua, Missoula, Mobile, Monticello, Mount Vernon, Muskegon, Nampa, Napa, New Albany, Newark, Newberg, New Richmond, New Ulm, Niles, Norton Shores, Oakland, O'Fallon, Oklahoma City, Ontario, Oregon City, Orlando, Ottawa, Paducah, Parma, Pekin, Peoria, Perrysburg, Peru, Pittsburgh, Plantation, Portland, Portsmouth, Port Townsend, Post Falls, Princeton, Ravenna, Redmond, Reed City, Rice Lake, Richmond, Robbinsdale, Rolla, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, San Diego, Sandpoint, Sandusky, Santa Rosa, Savannah, Seattle, Sedro-Woolley, Shakopee, Shelton, Sheridan, Sioux Falls, Springfield, Statesville, Stevens Point, Stillwater, St Louis, Sullivan, Sunset Hills, Swansea, Tampa, Thornton, Toledo, Traverse City, Troy, Twin Falls, Urbana, Vancouver, Waconia, Wadsworth, Walla Walla, Walnut Creek, Warren, Washington, Wausau, West Chester, West Des Moines, Westerville, Westlake, Weston, Wilkesboro, Willmar, Winston-Salem, Wisconsin Rapids, Woodbury, Wyoming, Yelm, Yorkville, Youngstown, Zanesville
Age
18 years and over
People
112
Run by
SWOG Cancer Research Network
See details and how to joinNCT04511013
Phase 1Taking people
A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma
Where
Harrison, New York
Age
18 years and over
People
40
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05607095
Phase 2Taking people
Sulforaphane for the Prevention of Melanoma in Patients With Multiple Atypical Nevi and a Prior History of Melanoma
Where
Pittsburgh
Age
18 years and over
People
120
Run by
ECOG-ACRIN Cancer Research Group
See details and how to joinNCT07040280