Melanoma trials in United States

In United States 268 Also abroad 578

268 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Study of Adjuvant Darovasertib and Crizotinib in Participants With Primary Non-metastatic Uveal Melanoma
Where
Boston, Cleveland, Grand Rapids, Los Angeles, Madison, Nashville, New York, Philadelphia, Raleigh, Scottsdale
Age
18 years and over
People
450 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07804186
No phaseNot yet taking people in United States
Optimizing Tumor-Infiltrating Lymphocyte (TIL) Harvest Site and Patient Selection With CD8-PET Imaging in Patients With
Where
Houston
Age
18 years and over
People
6
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07819474
No phaseTaking people
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Where
Appleton, Aurora, Birmingham, Boston, Broomall, Chandler, Chapel Hill, Cincinnati, Cleveland, Dallas, East Brunswick, Edinburg, Forth Worth, Grand Rapids, Hollywood, Hot Springs, La Jolla, Lakeland, Lewiston, Myrtle Beach, New Orleans, Newport Beach, New York, Philadelphia, Redwood City, Rochester, Rock Hill, Sacramento, Salt Lake City, San Antonio, Shreveport, Toledo, York
Age
18 years and over
People
2,285 worldwide
Run by
Guardant Health, Inc.
See details and how to joinNCT05059444
Phase 2Not yet taking people in United States
Fianlimab&Cemiplimab as TotalNeoadj The (TNT) ForMelanoma
Where
Orange
People
35
Run by
University of California, Irvine
See details and how to joinNCT07527325
Phase 3Not yet taking people in United States
iSCIB1+ in Combination With Ipilimumab and Nivolumab as First-Line Treatment for Advanced Unresectable Melanoma
Where
Aurora
Age
18 years and over
People
550 worldwide
Run by
Scancell Ltd
See details and how to joinNCT07815574
Phase 2Taking people
Preoperative Radiotherapy and Immunotherapy for Sinonasal and Anorectal Mucosal Melanoma
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05546827
Phase 2Taking people
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
Where
Boston
Age
18 years and over
People
134
Run by
Brigham and Women's Hospital
See details and how to joinNCT04899908
Phase 2Taking people
Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma
Where
Aurora, Columbus, Pittsburgh, Washington D.C.
Age
18 years and over
People
44
Run by
Diwakar Davar
See details and how to joinNCT06070012
Phase 1/2Taking people
DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma
Where
Birmingham, Boston, Chapel Hill, Dallas, Duarte, Gilbert, Morristown, Scottsdale
Age
18 years and over
People
35
Run by
Diakonos Oncology Corporation
See details and how to joinNCT07288112
Phase 1Taking people
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
Where
Cleveland, Denver, Fairfax, Houston, Jacksonville, Los Angeles, Morristown, Nashville, New Brunswick, New York, Orlando, Rochester, San Diego, San Francisco
Age
18 years and over
People
400 worldwide
Run by
Pierre Fabre Medicament
See details and how to joinNCT04913285
No phaseTaking people
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years and over
People
26
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05837767
Phase 2Taking people
Study of the Efficacy of Intratumoral L19IL2 or L19TNF or L19IL2/L19TNF, in Combination With Pembrolizumab, in Unresectable Melanoma Patients
Where
Hartford, New York
Age
18 years and over
People
162 worldwide
Run by
Philogen S.p.A.
See details and how to joinNCT06284590 · EU 2024-519326-20-00
Phase 1/2Taking people
Phase I/IIa Dose Finding Study of Triplet Regimen of Relatlimab Ipilimumab and NIvolumab in First Line Therapy of Metastatic Melanoma (TRINITY)
Where
Houston
Age
18 years and over
People
30
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06683755
Phase 2Taking people
Cryoablation+Ipilimumab+Nivolumab in Melanoma
Where
Boston
Age
18 years and over
People
37
Run by
Massachusetts General Hospital
See details and how to joinNCT05779423
Phase 4Not yet taking people in United States
Impact of Dysport on PMFF Donor Scar
Where
Nashville
Age
18 years and over
People
50
Run by
Vanderbilt University Medical Center
See details and how to joinNCT07720726
Phase 1/2Taking people
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Where
Ann Arbor, Atlanta, Aurora, Birmingham, Boston, Chicago, Cincinnati, Houston, Indianapolis, Los Angeles, Memphis, Minneapolis, New York, Orange, Palo Alto, Philadelphia, Pittsburgh, San Francisco, Seattle, St Louis, Washington D.C.
Age
12 months to 30 years
People
147
Run by
Children's Oncology Group
See details and how to joinNCT04851119
Phase 2Taking people
ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab
Where
New York
Age
18 years and over
People
90
Run by
NYU Langone Health
See details and how to joinNCT07504796
No phaseTaking people
Molecular Testing for the MD Anderson Cancer Center Personalized Cancer Therapy Program
Where
Houston
People
12,000
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT01772771
Phase 2Taking people
A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab
Where
Bethesda
Age
18 years to 72 years
People
53
Run by
National Cancer Institute (NCI)
See details and how to joinNCT02621021
Phase 1/2Taking people
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Where
Jacksonville
Age
16 years and over
People
138
Run by
Mayo Clinic
See details and how to joinNCT05269381
Phase 1Taking people
Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors
Where
Chapel Hill
Age
18 years to 99 years
People
45
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT03454035
No phaseTaking people
High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial
Where
Boston, Seattle
Age
18 years and over
People
40
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06298734
Phase 3Enrolling by invitation
A Long-Term Follow-Up Study of Subjects Completing the AU-011-301(CoMpass) for Early Choroidal Melanoma
Where
Ann Arbor, Austin, Greenville, Madison, Nashville, Oklahoma City, Rochester, Sacramento, Salt Lake City, Southlake
Age
18 years and over
People
100 worldwide
Run by
Aura Biosciences
See details and how to joinNCT07338968 · EU 2025-524405-33-00
Phase 2Taking people
Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma
Where
La Jolla, San Francisco
Age
18 years and over
People
25
Run by
University of California, San Francisco
See details and how to joinNCT04598009
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Clovis, Hackensack, Houston, Iowa City, Los Angeles, Nashville, Newport Beach, New York, Portland
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709