Multiple sclerosis trials in United States

In United States 185 Also abroad 503

185 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab
Where
Atlanta, Birmingham, Boston, Charlotte, Chicago, Cincinnati, Cleveland, Cullman, Dayton, Farmington, Fort Collins, Foxborough, Golden Valley, Greenville, Houston, Indianapolis, Iowa City, Kirkland, Knoxville, Lutherville, Milwaukee, New York, North Worcester, Oklahoma City, Orange, Overland Park, Plymouth, Raleigh, Salt Lake City, Savannah, Seattle, Spokane, St Louis, Tampa, Vienna, Washington D.C., Wellesley
Age
18 years to 65 years
People
800 worldwide
Run by
TG Therapeutics, Inc.
See details and how to joinNCT05877963 · EU 2024-519284-18-00
No phaseTaking people
Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
Where
Atlanta
Age
18 years to 89 years
People
138
Run by
Emory University
See details and how to joinNCT06495138
No phaseNot yet taking people in United States
Efficacy of Seated Physical Activity INtervention(SPIN) for Wheelchair Users With Multiple Sclerosis
Where
Houston
Age
18 years and over
People
100
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07891520
Phase 1/2Taking people
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Where
Bethesda
Age
18 years to 120 years
People
250
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03109288
Phase 3Taking people
Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)
Where
Aurora, Charlottesville, Cincinnati, Cleveland, Dallas, Detroit, Durham, Evanston, Houston, Milwaukee, Minneapolis, New York, Palo Alto, Philadelphia, Portland, Richmond, Rochester, Seattle, St Louis, Worcester
Age
18 years to 55 years
People
156
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT04047628
Phase 1Taking people
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS
Where
Naples
People
15 worldwide
Run by
The Foundation for Orthopaedics and Regenerative Medicine
See details and how to joinNCT05003388
Phase 1Taking people
Study of KITE-363 in Participants With Autoimmune Neurologic Diseases That Did Not Respond to Usual Treatment
Where
Newport Beach, New York, Palo Alto, Salt Lake City, Seattle
Age
18 years to 75 years
People
57 worldwide
Run by
Kite, A Gilead Company
See details and how to joinNCT07304154
Phase 1Taking people
Obe-cel in Refractory Progressive Forms of Multiple Sclerosis
Where
Palo Alto
Age
18 years to 60 years
People
24 worldwide
Run by
Autolus Limited
See details and how to joinNCT07139743 · EU 2024-519552-93-00
No phaseTaking people
Early Versus Delayed Start of Ocrevus Zunovo for Relapsing Multiple Sclerosis
Where
Oklahoma City
Age
18 years and over
People
45
Run by
Oklahoma Medical Research Foundation
See details and how to joinNCT07878923
Phase 2Taking people
Comparing Telehealth-Delivered CBT-I to Web-Based CBT-I to Enhance Sleep, Reduce Fatigue, and Promote Neuroprotection
Where
Kansas City
Age
18 years to 65 years
People
90
Run by
University of Kansas Medical Center
See details and how to joinNCT06434571
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Where
Albuquerque, Altamonte Springs, Aurora, Bethesda, Birmingham, Charlotte, Chicago, Cleveland, Cordova, Dallas, Farmington Hills, Foxborough, Frederick, Fullerton, Gainesville, Greenville, Homestead, Honolulu, Kansas City, Maitland, Miami, Naples, Nashville, Newport Beach, Orlando, Ormond Beach, Phoenix, Plano, Raleigh, Seattle, Smyrna, Spokane, Tampa, Tucson, Washington D.C., Wellesley, West Hollywood, Worchester
Age
18 years to 65 years
People
1,275 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07225504
Phase 3Taking people
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Where
Abington, Altamonte Springs, Atlanta, Aurora, Baltimore, Charlotte, Columbus, Cullman, El Paso, Farmington Hills, Fort Collins, Foxborough, Gainesville, Homewood, Knoxville, Lancaster, Milwaukee, Naples, Northbrook, Orlando, Ormond Beach, Phoenix, Plano, Raleigh, San Antonio, Scottsdale, Smyrna, Tampa, Teaneck, Tucson, West Hollywood, West Palm Beach
Age
18 years to 60 years
People
160 worldwide
Run by
Sanofi
See details and how to joinNCT07325292 · EU 2026-525688-41-00
Phase 1/2Not yet taking people in United States
C-CAR168, an Autologous Anti-CD20/BCMA Chimeric Antigen Receptor T-Cell Therapy, in Participants With Progressive Multiple Sclerosis Refractory to Standard Therapy
Where
Gilbert, La Jolla
Age
18 years to 55 years
People
119
Run by
AbelZeta Inc.
See details and how to joinNCT07825389
No phaseTaking people
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
Where
Bethesda
Age
1 month to 99 years
People
2,400
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT00794352
Phase 1Taking people
Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects
Where
Boston
Age
18 years to 65 years
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT04699747
Early phase 1Taking people
Entire-body PET Scans for Multiple Sclerosis
Where
Ladera Ranch
Age
25 years to 55 years
People
20
Run by
Brain Health Alliance
See details and how to joinNCT04390009
No phaseTaking people
The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis
Where
Chicago
Age
18 years and over
People
50
Run by
University of Illinois Chicago
See details and how to joinNCT07504120
Phase 2Taking people
Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
Where
Bethesda
Age
18 years to 120 years
People
30
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT02784210
Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
No phaseTaking people
A Study of the MIND Diet for Persons With Multiple Sclerosis
Where
New York
Age
18 years to 70 years
People
100
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06992115
Phase 3Not yet taking people in United States
Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project
Where
Boca Raton
Age
18 years and over
People
60
Run by
University of Miami
See details and how to joinNCT07472413
Phase 1Taking people
Vancomycin Study in Multiple Sclerosis (MS)
Where
New York
Age
18 years to 50 years
People
12
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT05539729
No phaseNot yet taking people in United States
Evaluation of an Online, On Demand Multimodal Wellness Program to Reduce Fatigue and Improve Quality of Life in Progressive Multiple Sclerosis.
Where
Iowa City
Age
45 years to 70 years
People
118
Run by
University of Iowa
See details and how to joinNCT07831928
No phaseTaking people
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
Where
Birmingham
Age
18 years to 64 years
People
22
Run by
University of Alabama at Birmingham
See details and how to joinNCT07475377
Phase 1/2Taking people
Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
Where
Cincinnati, Durham, Kansas City, La Jolla, New York, Rochester, Seattle, St Louis
Age
18 years to 65 years
People
39
Run by
Tr1X, Inc.
See details and how to joinNCT07477639