Multiple sclerosis trials in United States

In United States 185 Also abroad 503

185 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Enrolling by invitation
A Study of Imaging in Demyelinating Diseases
Where
Rochester
Age
18 years and over
People
200
Run by
Mayo Clinic
See details and how to joinNCT05805839
No phaseTaking people
Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis
Where
Houston
Age
18 years and over
People
66
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT07606742
No phaseTaking people
Clinical Applications of Advanced Ophthalmic Imaging
Where
Miami
Age
18 years to 99 years
People
5,000
Run by
University of Miami
See details and how to joinNCT03135327
No phaseTaking people
Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation
Where
Richardson
Age
18 years to 65 years
People
100
Run by
The University of Texas at Dallas
See details and how to joinNCT05958381
Phase 2Taking people
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Austin, Birmingham, Boston, Buffalo, Chapel Hill, Charlottesville, Chicago, Cleveland, Columbus, Draper, Honolulu, Kansas City, Knoxville, Madison, New York, Novi, Omaha, Philadelphia, Rockville, San Diego, Santa Rosa, Seattle, Shreveport, Tampa, Towson, Tucson, Worcester
Age
18 years to 80 years
People
100
Run by
Reunion Neuroscience Inc
See details and how to joinNCT07002034
No phaseEnrolling by invitation
FES: Effect on Walking in the Real World and Participation in Daily Life in People With Multiple Sclerosis.
Where
San Francisco
Age
22 years to 75 years
People
70
Run by
University of California, San Francisco
See details and how to joinNCT07706114
Phase 3Taking people
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Where
Chicago, Cincinnati, El Paso, Loma Linda, Louisville, Milwaukee, New Brunswick, Portland, Sacramento, Tampa, Teaneck
Age
10 years to 17 years
People
194 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06408259 · EU 2022-501332-42-00
Phase 1Taking people
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
Where
New Haven
Age
18 years to 90 years
People
105
Run by
Yale University
See details and how to joinNCT06999434
No phaseEnrolling by invitation
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
Where
Baltimore, Nashville, Portland, Seattle, Waltham, Washington D.C.
Age
22 years and over
People
2,000
Run by
Accelerated Cure Project for Multiple Sclerosis
See details and how to joinNCT06441617
No phaseTaking people
The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot Study
Where
Atlanta, Austin, Baltimore, Houston, Irvine, Milwaukee, Morgantown, Plymouth, Seattle
Age
22 years to 60 years
People
60
Run by
SetPoint Medical Corporation
See details and how to joinNCT06796504
No phaseTaking people
Identifying and Characterizing Preclinical MS
Where
North Haven
Age
18 years and over
People
1,000
Run by
Yale University
See details and how to joinNCT05787795
Phase 1Taking people
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
Where
Aurora, Cleveland, Milwaukee, New York, Seattle, St Louis, Tucson, Washington D.C.
Age
18 years to 60 years
People
24 worldwide
Run by
AstraZeneca
See details and how to joinNCT07224373
Early phase 1Not yet taking people in United States
Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
Where
Pittsburgh, Washington D.C.
Age
18 years and over
People
48
Run by
Medstar Health Research Institute
See details and how to joinNCT07643974
No phaseTaking people
A Study Comparing Effectiveness of Kesimpta® (Ofatumumab) Versus Ocrevus® (Ocrelizumab) in Real-world Practice
Where
East Hanover
Age
18 years to 100 years
People
7,466
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07779460
Phase 2Not yet taking people in United States
A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS
Where
Cleveland
Age
18 years to 60 years
People
20
Run by
Moein Amin
See details and how to joinNCT07222956
No phaseTaking people
Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study
Where
Austin
Age
18 years to 80 years
People
64
Run by
University of Texas at Austin
See details and how to joinNCT07759115
No phaseTaking people
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
Where
Cleveland
Age
18 years and over
People
60
Run by
Louis Stokes VA Medical Center
See details and how to joinNCT07768761
Phase 3Taking people
Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research
Where
Charleston, Dallas, Houston, Livonia
Age
18 years to 50 years
People
210
Run by
Oculis
See details and how to joinNCT07623668
No phaseTaking people
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Where
Aurora, Durham
People
908 worldwide
Run by
Biogen
See details and how to joinNCT05658497
No phaseTaking people
Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)
Where
San Francisco
Age
18 years to 64 years
People
250
Run by
University of California, San Francisco
See details and how to joinNCT06940323
No phaseTaking people
Brain Imaging and Immune Changes During Remibrutinib Treatment in Multiple Sclerosis.
Where
St Louis
Age
40 years to 70 years
People
15
Run by
Washington University School of Medicine
See details and how to joinNCT07758270
No phaseTaking people
A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis
Where
East Hanover
Age
18 years to 70 years
People
78
Run by
Kessler Foundation
See details and how to joinNCT06197685
No phaseTaking people
This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.
Where
St Louis
Age
18 years and over
People
80
Run by
Washington University School of Medicine
See details and how to joinNCT07115017
No phaseTaking people
Exploration of Novel Imaging Biomarkers on OCT for Ublituximab Treatment Response in Multiple Sclerosis
Where
Baltimore
Age
18 years to 65 years
People
30
Run by
University of Maryland, Baltimore
See details and how to joinNCT06864936
No phaseTaking people
Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia
Where
Lawrenceville
People
15
Run by
Bristol-Myers Squibb
See details and how to joinNCT07732907