Opioid use disorder trials in United States

In United States 229 Also abroad 254

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Adapting the Penny Chatbot for Perinatal OUD Patients: COPILOT
Where
Philadelphia
People
20
Run by
University of Pennsylvania
See details and how to joinNCT06969261
No phaseEnrolling by invitation
Pre-Pilot (R61) WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD
Where
Newburgh, New York
Age
18 years and over
People
7
Run by
Dawn A. Goddard-Eckrich
See details and how to joinNCT07665502
No phaseTaking people
A Unique, Co-Designed Family-Based Therapy
Where
Columbus
Age
18 years and over
People
120
Run by
Ohio State University
See details and how to joinNCT07587359
Phase 4Taking people
Low-dose Buprenorphine Initiation for Opioid Use Disorder
Where
The Bronx
Age
18 years and over
People
70
Run by
Montefiore Medical Center
See details and how to joinNCT05450718
Phase 2Taking people
Outpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder
Where
Baltimore
Age
21 years to 70 years
People
90
Run by
Johns Hopkins University
See details and how to joinNCT06067737
No phaseTaking people
Adversity, Brain and Opioid Use Study
Where
Ann Arbor
Age
18 years to 55 years
People
185
Run by
University of Michigan
See details and how to joinNCT06355778
No phaseTaking people
Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery
Where
La Jolla
Age
18 years and over
People
100
Run by
University of California, San Diego
See details and how to joinNCT07693270
No phaseTaking people
Mindfulness Texting for Medication Adherence and Chronic Pain Management
Where
Albuquerque
Age
18 years and over
People
60
Run by
University of New Mexico
See details and how to joinNCT07711795
Phase 2Taking people
Combined THC and CBD for OUD and Chronic Pain
Where
New Haven
Age
18 years to 65 years
People
147
Run by
Yale University
See details and how to joinNCT06544291
No phaseTaking people
Methadone Patient Access to Collaborative Treatment
Where
Tucson
Age
18 years and over
People
1,080
Run by
University of Arizona
See details and how to joinNCT06556602
No phaseTaking people
Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery
Where
Bridgeport, Enfield, West Haven
Age
18 years and over
People
532
Run by
Yale University
See details and how to joinNCT07115030
No phaseEnrolling by invitation
Multimodal Fetal and Placental Imaging and Biomarkers of Clinical Outcomes in Opioid Use Disorder
Where
Indianapolis, Pittsburgh
Age
18 years to 100 years
People
250
Run by
Senthil Sadhasivam
See details and how to joinNCT06415994
No phaseEnrolling by invitation
Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare Workers and Peer Supporters, and Implementation of Evidence Based Interventions.
Where
Columbus
Age
18 years and over
People
200
Run by
Alicia Bunger
See details and how to joinNCT07439783
Phase 2Taking people
Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use
Where
Philadelphia
Age
18 years and over
People
60
Run by
University of Pennsylvania
See details and how to joinNCT06379984
No phaseTaking people
Autobiographical Memory in Opioid Use Disorder
Where
Philadelphia
Age
18 years to 60 years
People
30
Run by
University of Pennsylvania
See details and how to joinNCT06643988
Phase 2Taking people
Psilocybin on Brain Mechanisms of Motivation in OUD
Where
Philadelphia
Age
18 years to 60 years
People
24
Run by
University of Pennsylvania
See details and how to joinNCT06810310
Phase 2Taking people
Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects
Where
Richmond
Age
18 years and over
People
100
Run by
Virginia Commonwealth University
See details and how to joinNCT06981195
Phase 1Taking people
Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine
Where
Madison
Age
21 years to 65 years
People
10
Run by
University of Wisconsin, Madison
See details and how to joinNCT04161066
Phase 1Taking people
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Where
New Haven
Age
25 years to 55 years
People
12
Run by
Yale University
See details and how to joinNCT06160284
No phaseNot yet taking people in United States
Family-Focused Study to Support Medication for Opioid Use Disorder
Where
Chicago, Madison
Age
18 years and over
People
338
Run by
University of Wisconsin, Madison
See details and how to joinNCT07451197
No phaseTaking people
An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)
Where
Philadelphia
Age
18 years and over
People
50
Run by
University of Pennsylvania
See details and how to joinNCT06576323
Phase 1Taking people
Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
Where
Minneapolis
Age
18 years and over
People
40
Run by
University of Minnesota
See details and how to joinNCT07158853
Phase 2Taking people
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
Where
Spokane
Age
18 years and over
People
60
Run by
Washington State University
See details and how to joinNCT06323837
No phaseTaking people
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
Where
Boston
Age
18 years and over
People
185,810
Run by
Boston University
See details and how to joinNCT07232641
No phaseTaking people
tDCS to Decrease Opioid Relapse (UH3)
Where
Providence
Age
21 years to 60 years
People
100
Run by
Butler Hospital
See details and how to joinNCT06432465