Opioid use disorder trials in United States

In United States 229 Also abroad 254

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department
Where
San Francisco
Age
18 years and over
People
300
Run by
University of California, San Francisco
See details and how to joinNCT06872190
No phaseTaking people
Telehealth vs In-Person Evaluation of Addiction Treatment After Visiting the Emergency Department
Where
El Centro, Sacramento, Sylmar
Age
18 years and over
People
528
Run by
University of California, Davis
See details and how to joinNCT06961058
Phase 2Taking people
Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City
Where
St Louis
Age
18 years and over
People
300
Run by
Washington University School of Medicine
See details and how to joinNCT07673380
No phaseTaking people
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
Where
Baltimore, Morgantown, New York, Tampa
Age
18 years to 60 years
People
29
Run by
InSightec
See details and how to joinNCT04197921
Phase 2Taking people
Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
Where
Pittsburgh
Age
18 years to 100 years
People
40
Run by
Sanjay R Patel
See details and how to joinNCT06521476
Phase 3Taking people
Smartphones for Opiate Addiction Recovery
Where
New York, Piscataway
Age
18 years to 85 years
People
225
Run by
NYU Langone Health
See details and how to joinNCT05033028
Early phase 1Taking people
Measuring Acute Drug Demand in Humans
Where
Baltimore
Age
18 years to 65 years
People
75
Run by
University of Maryland, Baltimore
See details and how to joinNCT05829655
No phaseNot yet taking people in United States
Resilience Among Individuals With Opioid Use Disorder
Where
Baltimore
Age
18 years and over
People
125
Run by
Johns Hopkins University
See details and how to joinNCT06954402
No phaseTaking people
Brief Digitally-Enhanced Intervention for Reducing Alcohol Use During MOUD
Where
Columbus
Age
18 years and over
People
80
Run by
Ohio State University
See details and how to joinNCT06718491
Phase 1Taking people
Cannabis and Opioid Use Disorder
Where
Lexington
Age
18 years to 55 years
People
15
Run by
Shanna Babalonis, PhD
See details and how to joinNCT05729932
No phaseEnrolling by invitation
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails
Where
Little Rock
Age
18 years and over
People
338
Run by
University of Arkansas
See details and how to joinNCT07490717
No phaseTaking people
Opioid Use Disorder and Pain
Where
New Haven
Age
21 years to 60 years
People
180
Run by
Yale University
See details and how to joinNCT06800703
Phase 4Taking people
Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP
Where
New Haven
Age
18 years and over
People
256
Run by
University of Connecticut
See details and how to joinNCT05669534
No phaseTaking people
Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment
Where
El Centro, Irvine, Placerville, Sacramento
Age
14 years and over
People
3,492
Run by
University of California, Davis
See details and how to joinNCT07024498
No phaseTaking people
Adaptive Decision Support for Addiction Treatment Master
Where
Guilford, New Haven
Age
18 years and over
People
1,912
Run by
Yale University
See details and how to joinNCT06799117
Phase 3Not yet taking people in United States
Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial
Where
The Bronx
Age
18 years and over
People
40
Run by
Montefiore Medical Center
See details and how to joinNCT07148206
No phaseTaking people
Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment
Where
Notre Dame
Age
18 years and over
People
60
Run by
University of Notre Dame
See details and how to joinNCT07342504
No phaseTaking people
Postpartum Intervention for Mothers With Opioid Use Disorders (R33)
Where
Ann Arbor, Stony Brook
Age
18 years to 50 years
People
80
Run by
Stony Brook University
See details and how to joinNCT07632053
No phaseEnrolling by invitation
Mobile Mindfulness Training (mMT) for People in Medication Treatment of Opioid Use Disorder (MOUD)
Where
Lexington
Age
18 years to 65 years
People
60
Run by
Amy Meadows
See details and how to joinNCT06857968
No phaseNot yet taking people in United States
Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs
Where
San Francisco
Age
18 years and over
People
50
Run by
University of California, San Francisco
See details and how to joinNCT07631559
Phase 3Taking people
Buprenorphine for Individuals in Jail
Where
Baltimore
Age
18 years and over
People
240
Run by
Friends Research Institute, Inc.
See details and how to joinNCT06306443
No phaseTaking people
Craving & Decision-Making
Where
Piscataway
Age
18 years and over
People
160
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT06440577
Phase 4Taking people
Integrated e-Health (Electronic Health) for HIV and Substance Use Disorders in Justice Involved Women
Where
Birmingham, New Haven
Age
18 years and over
People
250
Run by
Yale University
See details and how to joinNCT05547048
Early phase 1Taking people
A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use
Where
New York
Age
18 years to 65 years
People
60
Run by
Rachel R. Luba
See details and how to joinNCT06726200
No phaseEnrolling by invitation
Peer Recovery Support for Opioid Use Disorder Treatment Retention
Where
Philadelphia
Age
18 years and over
People
15
Run by
University of Pennsylvania
See details and how to joinNCT07620171