Opioid use disorder trials in United States

In United States 229 Also abroad 254

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 4Taking people
Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery
Where
St Louis
Age
18 years and over
People
100
Run by
Jenna-Leigh Wilson
See details and how to joinNCT06949826
No phaseNot yet taking people in United States
NeuroCuple to Mitigate Post-Wisdom Teeth Extraction Opioid Risks
Where
Pittsburgh
Age
18 years to 50 years
People
120
Run by
nCap Medical
See details and how to joinNCT07461506
Phase 3Taking people
Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3
Where
Atlanta
Age
18 years to 75 years
People
103
Run by
Emory University
See details and how to joinNCT05834478
Phase 2Taking people
Remotely Observed Methadone Evaluation II
Where
Chicago
Age
18 years to 64 years
People
100
Run by
Sonara Health
See details and how to joinNCT06338280
No phaseTaking people
Preoperative Opioid Tapering Before Spine Surgery
Where
Philadephia
Age
18 years and over
People
45
Run by
Thomas Jefferson University
See details and how to joinNCT07221786
No phaseTaking people
Adolescent Outcomes of Post-operative Opioid EXposure
Where
Aurora, Boston, Cincinnati, Philadelphia, St. Petersburg
Age
12 years to 17 years
People
20,000
Run by
Sharon Levy
See details and how to joinNCT06350409
Phase 2Taking people
MDMA for Co-occurring PTSD and OUD After Childbirth
Where
Albuquerque
Age
18 years and over
People
15
Run by
University of New Mexico
See details and how to joinNCT05219175
No phaseTaking people
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Where
Eugene
Age
18 years and over
People
341
Run by
Chestnut Health Systems
See details and how to joinNCT06852170
No phaseTaking people
Optimization of NIBS for Treatment of Addiction
Where
Cambridge, Cleveland, Hinsdale
Age
18 years to 85 years
People
126
Run by
Case Western Reserve University
See details and how to joinNCT04379115
No phaseTaking people
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Where
Chicago
Age
18 years and over
People
600
Run by
University of Illinois Chicago
See details and how to joinNCT06823453
No phaseTaking people
Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder
Where
Colton
Age
18 years and over
People
500
Run by
RAND
See details and how to joinNCT06827288
No phaseTaking people
HIV, Equity, and Addiction Training (HEAT) Program
Where
Birmingham
Age
18 years and over
People
30
Run by
University of Alabama at Birmingham
See details and how to joinNCT06370481
No phaseTaking people
Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment
Where
Danville
Age
18 years to 89 years
People
218
Run by
Geisinger Clinic
See details and how to joinNCT07197801
No phaseTaking people
LIFU for Treatment for Refractory Opioid Use Disorder
Where
Morgantown
Age
22 years to 60 years
People
34
Run by
Ali Rezai
See details and how to joinNCT06218706
No phaseTaking people
Sensory Outcomes in Active Substance Users
Where
Boston
Age
18 years and over
People
40
Run by
Boston Medical Center
See details and how to joinNCT06639438
No phaseEnrolling by invitation
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
Where
Indianapolis
People
400
Run by
Indiana University
See details and how to joinNCT06084221
No phaseTaking people
Interpersonal Brain Function in Opioid Use
Where
La Jolla
Age
18 years and over
People
60
Run by
University of California, San Diego
See details and how to joinNCT07386769
Phase 2/3Taking people
Divided or Single Exposure (DOSE) Study
Where
Baltimore
Age
18 years to 100 years
People
150
Run by
University of Maryland, Baltimore
See details and how to joinNCT05459402
Phase 3Taking people
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
Where
La Jolla, New Brunswick, Salt Lake City
Age
18 years and over
People
300
Run by
University of Utah
See details and how to joinNCT06387290
Phase 2Taking people
Psilocybin for Opioid Use Disorder (OUD)
Where
Albuquerque, Brooklyn, New York, The Bronx
Age
18 years to 65 years
People
480
Run by
NYU Langone Health
See details and how to joinNCT06796062
No phaseTaking people
Opioid Adherence and Support Through Innovative Texting Strategies
Where
Albuquerque
Age
18 years and over
People
60
Run by
University of New Mexico
See details and how to joinNCT07350148
No phaseTaking people
OUD (Opioid Use Disorder) Target Trial
Where
Durham
Age
18 years and over
People
80
Run by
Duke University
See details and how to joinNCT06585709
No phaseTaking people
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Where
Durham
Age
21 years and over
People
60
Run by
Duke University
See details and how to joinNCT06747871
No phaseNot yet taking people in United States
Reentry Incentives and Support for Engagement With Contingency Management
Where
Warrenton
Age
18 years and over
People
75
Run by
Oregon Health and Science University
See details and how to joinNCT07322588
Phase 2Not yet taking people in United States
Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
Where
Detroit
Age
21 years to 60 years
People
20
Run by
Wayne State University
See details and how to joinNCT04231708