Sickle cell disease trials in United States

In United States 133 Also abroad 204

133 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Where
Pittsburgh
Age
5 years to 40 years
People
5
Run by
Paul Szabolcs
See details and how to joinNCT03653338
No phaseTaking people
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
Where
Cincinnati
Age
14 years to 80 years
People
120
Run by
University of Cincinnati
See details and how to joinNCT06725550
Phase 3Enrolling by invitation
A Long-term Follow-up Study in Participants Who Received CTX001
Where
Charlotte, Chicago, Memphis, Nashville, New York, Palo Alto, Philadelphia, San Antonio
Age
2 years to 64 years
People
160 worldwide
Run by
Vertex Pharmaceuticals Incorporated
See details and how to joinNCT04208529 · EU 2024-512654-19-00
No phaseTaking people
Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)
Where
Memphis
Age
8 years and over
People
145
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT05810181
Phase 1/2Not yet taking people in United States
Feasibility and Acceptability of Amani
Where
Boston
Age
18 years and over
People
40
Run by
Massachusetts General Hospital
See details and how to joinNCT07648043
Phase 1/2Taking people
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
Where
Atlanta
Age
7 years to 21 years
People
21
Run by
Emory University
See details and how to joinNCT02447874
Phase 2Taking people
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
Where
Gainesville, Los Angeles, Milwaukee, Valhalla
Age
6 months to 21 years
People
40
Run by
New York Medical College
See details and how to joinNCT02675959
Phase 2Taking people
Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
Where
Memphis
Age
Up to 22 years
People
45
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07616154
Phase 2Taking people
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
Where
Sacramento
Age
18 years to 80 years
People
30
Run by
University of California, Davis
See details and how to joinNCT06016634
No phaseTaking people
Early Life Exposures Among Children With Sickle Cell Disease
Where
Birmingham
Age
18 years to 50 years
People
20
Run by
University of Alabama at Birmingham
See details and how to joinNCT05377372
Phase 2Taking people
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease
Where
Chicago
Age
16 years to 60 years
People
50
Run by
University of Illinois Chicago
See details and how to joinNCT03121001
Phase 4Not yet taking people in United States
Low Dose Bolus Ketamine For Use In Sickle Cell Pain Crisis
Where
Jackson
Age
2 years to 21 years
People
400
Run by
University of Mississippi Medical Center
See details and how to joinNCT07682662
Phase 1/2Taking people
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
Where
Columbus, Los Angeles, New York, Palo Alto, St Louis
Age
12 years to 50 years
People
15
Run by
Kamau Therapeutics
See details and how to joinNCT04819841
No phaseNot yet taking people in United States
Solving Stigma Through POV Simulation: Enhancing Pharmacist Empathy-based Practices With Sickle Cell Disease Patients
Where
Columbus
Age
18 years and over
People
200
Run by
Ohio State University
See details and how to joinNCT07217548
No phaseTaking people
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
Where
Memphis
Age
12 years to 25 years
People
65
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06477289
No phaseTaking people
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation
Where
Cincinnati
People
200
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT04093986
No phaseTaking people
Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)
Where
Wilmington
Age
15 years and over
People
68
Run by
Nemours Children's Clinic
See details and how to joinNCT05383911
Phase 1Taking people
131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
Where
New York
Age
12 years to 50 years
People
24
Run by
Columbia University
See details and how to joinNCT07015684
No phaseTaking people
Investigation of the Genetics of Hematologic Diseases
Where
Memphis
People
1,716
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT02720679
Phase 4Taking people
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study
Where
Augusta, Birmingham, Fort Worth, Greenville, Philadelphia, Washington D.C.
Age
6 months to 100 years
People
130 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT04657822 · EU 2024-510734-41-00
No phaseTaking people
Sickle Cell Clinical Research and Intervention Program
Where
Baton Rouge, Charlotte, Memphis, Peoria
People
10,000
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT02098863
No phaseTaking people
Let's Get REAL: Family Health Communication Tool in Pediatric Stem Cell Transplant and Cellular Therapy
Where
St Louis
Age
8 years and over
People
60
Run by
Washington University School of Medicine
See details and how to joinNCT06689800
Phase 2Taking people
Allo HSCT for High Risk Hemoglobinopathies
Where
Minneapolis
Age
Up to 55 years
People
62
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT06872333
No phaseTaking people
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
Where
Atlanta, Birmingham, Boston, Buffalo, Chapel Hill, Charlotte, Chicago, Columbus, Hackensack, Houston, Indianapolis, Memphis, New York, Oklahoma City, Philadelphia, Queens, Rochester, San Antonio, St Louis, The Bronx, Washington D.C., Wilmington
Age
3 years to 20 years
People
480 worldwide
Run by
University of Rochester
See details and how to joinNCT06941389
Phase 1/2Taking people
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
Where
Atlanta, Aurora, New Orleans, Philadelphia
Age
12 years to 45 years
People
24
Run by
Arkansas Children's Hospital Research Institute
See details and how to joinNCT07252050