Sickle cell disease trials in United States

In United States 133 Also abroad 204

133 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Functional Ovarian Reserve in Sickle Cell Disease
Where
Memphis
Age
10 years to 18 years
People
440
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07392216
Phase 2Taking people
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, Rockville Centre
Age
2 years to 50 years
People
24
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05736419
Phase 1/2Taking people
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
Where
Grand Rapids, New Haven, St Louis, Wilmington
Age
1 day to 21 years
People
29
Run by
Washington University School of Medicine
See details and how to joinNCT03128996
Phase 2Taking people
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
Where
Chicago
Age
18 years to 60 years
People
20
Run by
University of Illinois Chicago
See details and how to joinNCT07175051
No phaseTaking people
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease
Where
Memphis
Age
6 years to 25 years
People
76
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT03353584
No phaseTaking people
A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
Where
Atlanta, Cincinnati, Philadelphia, Wilmington
Age
13 years to 21 years
People
310
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT06290401
No phaseTaking people
SickleFit Exercise and Nutrition Study
Where
Durham
Age
35 years and over
People
40
Run by
Duke University
See details and how to joinNCT07442851
Phase 2Taking people
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
Where
Memphis
Age
18 years to 21 years
People
40
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT05583721
Phase 1/2Taking people
Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
Where
Los Angeles
Age
14 years to 21 years
People
66
Run by
Children's Hospital Los Angeles
See details and how to joinNCT05685368
No phaseTaking people
Predictors of Pain in Sickle Cell Disease
Where
Durham
Age
15 years to 40 years
People
70
Run by
Duke University
See details and how to joinNCT06139510
No phaseTaking people
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Where
Boston
Age
8 years to 25 years
People
25
Run by
Boston Children's Hospital
See details and how to joinNCT06555939
No phaseTaking people
Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders
Where
Memphis
Age
13 years and over
People
352
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT04416178
No phaseNot yet taking people in United States
Development of a Provider-Focused Intervention to Improve Health Outcomes in Pediatric Sickle Cell Disease
Where
Hartford
Age
18 years and over
People
30
Run by
Connecticut Children's Medical Center
See details and how to joinNCT07540767
Phase 1/2Taking people
RH Genotype Matched RBC Transfusions
Where
Philadelphia
Age
6 months and over
People
35
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT04156893
No phaseTaking people
School Readiness Intervention for Preschool Children With Sickle Cell Disease
Where
Memphis
Age
42 months to 78 months
People
36
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06367192
No phaseTaking people
ATHNdataset Registry
Where
Hickory
People
200,000
Run by
American Thrombosis and Hemostasis Network
See details and how to joinNCT06820515
Phase 3Taking people
Study of a Single Dose of a 21-valent Pneumococcal Conjugate Vaccine in Children and Adolescents With Sickle Cell Disease
Where
Atlanta, Houston, New Brunswick, Omaha
Age
2 years to 17 years
People
100 worldwide
Run by
Sanofi
See details and how to joinNCT07247188
Phase 2Taking people
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
Where
Washington D.C.
Age
4 years to 21 years
People
99
Run by
Suvankar Majumdar
See details and how to joinNCT06635902
No phaseTaking people
Sickle Cell Kidney Biorepository
Where
Dallas
Age
18 years to 65 years
People
800
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07064174
Phase 3Taking people
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease
Where
Charlotte, Nashville, New York
Age
12 years to 35 years
People
26 worldwide
Run by
Vertex Pharmaceuticals Incorporated
See details and how to joinNCT05477563 · EU 2024-514641-12-00
No phaseTaking people
Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease
Where
Chicago, Columbus, Nashville, St Louis
Age
18 years and over
People
287
Run by
Ohio State University
See details and how to joinNCT06919224
Phase 2Taking people
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
Where
Cincinnati, Durham, Houston, Oakland, Philadelphia
Age
15 years to 40 years
People
34
Run by
University of California, San Francisco
See details and how to joinNCT06260891
Phase 2Taking people
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
Where
Charlotte, Chicago, Columbus, New York, Washington D.C.
Age
2 years to 25 years
People
100 worldwide
Run by
Robert Nickel
See details and how to joinNCT03587272
Phase 3Not yet taking people in United States
Optimal Timing of Ketamine Initiation for SCD Pain
Where
Brookline
Age
6 years to 24 years
People
90
Run by
Boston Children's Hospital
See details and how to joinNCT07450430
Phase 2Taking people
Cognitive Remediation Intervention to Prepare for Transition of Care
Where
Birmingham
Age
10 years to 18 years
People
120
Run by
University of Alabama at Birmingham
See details and how to joinNCT05336201