Sjögren's disease trials in United States

In United States 23 Also abroad 80

23 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden
Where
Bellaire, Boston, Charlotte, Clearwater, Cooper City, Corpus Christi, Euless, Houston, Jackson, League City, Leander, Memphis, Oklahoma City, Peoria, Potsdam, Saint Clair Shores, Searcy, Spokane, Tampa, Van Nuys, Voorhees Township, Willowbrook, Wilmington
Age
18 years and over
People
570 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07621809 · EU 2025-522271-29-00
Phase 2Taking people
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease
Where
Allen, Avondale, Bellaire, Chicago, Clearwater, Corpus Christi, Duncansville, Memphis, Oklahoma City, Tampa, Willowbrook, Willow Grove
Age
18 years to 100 years
People
344 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07737743 · EU 2025-524513-92-00
Phase 1Not yet taking people in United States
R-2487 in Patients With Sjogren's Syndrome (SjD)
Where
Ann Arbor, Baltimore
Age
18 years to 80 years
People
36
Run by
Rise Therapeutics LLC
See details and how to joinNCT06297213
No phaseTaking people
The Pathogenesis and Natural History of Sjogren's Disease
Where
Bethesda
Age
16 years to 100 years
People
300
Run by
National Institute of Dental and Craniofacial Research (NIDCR)
See details and how to joinNCT01425892
No phaseTaking people
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Where
Bethesda
Age
9 years to 85 years
People
225
Run by
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
See details and how to joinNCT07829497
Phase 2Taking people
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease
Where
Bethesda
Age
18 years to 75 years
People
60
Run by
National Institute of Dental and Craniofacial Research (NIDCR)
See details and how to joinNCT07281456
No phaseTaking people
Characterization of Diseases With Salivary Gland Involvement
Where
Bethesda
Age
4 years to 100 years
People
1,150
Run by
National Institute of Dental and Craniofacial Research (NIDCR)
See details and how to joinNCT02327884
Phase 3Taking people
Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease
Where
Allen, Amarillo, Baytown, Bellaire, Beverly Hills, Boise, Boston, Chandler, Charlotte, Chesapeake, Chicago, Clearwater, Cooper City, Dallas, Denver, Duncansville, Durham, Euless, Flagstaff, Fort Collins, Fort Worth, Glendale, Green Acres, Houston, Irving, Kansas City, Katy, Lake Charles, Miami, New Port Richey, Oklahoma City, Philadelphia, Phoenix, Rockville, Saint Clair Shores, Sarasota, Schaumburg, South Miami, Tampa, Tucson, Waco, Willowbrook, Willow Grove, Winter Park
Age
18 years to 75 years
People
250 worldwide
Run by
Vor Biopharma
See details and how to joinNCT07404865 · EU 2026-525556-28-00
Phase 1Not yet taking people in United States
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Where
Ann Arbor, Great Neck, Morristown, Newport Beach, Omaha, Philadelphia, Saint Paul, Salt Lake City, Seattle, Worcester
Age
18 years and over
People
60 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07873931
Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
No phaseEnrolling by invitation
Comparative Autoantibody and Immunologic Cell Marker Study
Where
Atlanta
Age
18 years and over
People
2,500
Run by
Emory University
See details and how to joinNCT02422875
Phase 1Taking people
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
Where
Madison
Age
18 years to 90 years
People
36
Run by
University of Wisconsin, Madison
See details and how to joinNCT06392711
Phase 1Taking people
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
Where
Brooklyn, Memphis, Orlando, Plano, Salt Lake City, Webster
Age
18 years and over
People
36 worldwide
Run by
Cullinan Therapeutics Inc.
See details and how to joinNCT07041099
Phase 1Taking people
A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE), Sjogren's Disease (SjD) and Rheumatoid Arthritis (RA)
Where
Avon Park, Clearwater, Harlingen, Margate, Memphis, Orland Park, Tampa
Age
18 years to 75 years
People
36 worldwide
Run by
AbbVie
See details and how to joinNCT06977724 · EU 2024-519157-10-00
No phaseTaking people
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
Where
Iowa City
Age
18 years to 100 years
People
400
Run by
Terry L. Wahls
See details and how to joinNCT07180537
Phase 2Taking people
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
Where
Arlington, Bellaire, Charleston, Charlotte, Chula Vista, Covina, Gainesville, Great Falls, Hixson, Iowa City, Irving, Jackson, Jupiter, Katy, Los Alamitos, Los Angeles, Mesquite, Miami, Norcross, Phoenix, Plantation, Red Oak, Roanoke, Santa Ana, Statesville, Tucson, Tuscaloosa, Tustin, Willowbrook, Woodland
Age
18 years and over
People
90 worldwide
Run by
Artiva Biotherapeutics, Inc.
See details and how to joinNCT06991114 · EU 2025-520461-41-00
No phaseNot yet taking people in United States
Sjogren's Mini-Pill Oral and Gut Microbiome Study
Where
Boston
People
90
Run by
Tufts University
See details and how to joinNCT07732582
Phase 3Taking people
A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)
Where
Avondale, Baytown, Beckley, Boston, Bothell, Bradenton, Charlotte, Clearwater, Colleyville, Covina, Durham, Flagstaff, Fort Collins, Gilbert, Glendale, Kansas City, Katy, La Jolla, McAllen, Miamisburg, Murfreesboro, Saint Clair Shores, Salisbury, Tampa, The Woodlands, Toledo, Tomball, Tucson, Vandalia, Voorhees Township
Age
18 years and over
People
844 worldwide
Run by
Amgen
See details and how to joinNCT06747949 · EU 2024-517513-32-00
No phaseNot yet taking people in United States
Penn SICCA Follow-up Study
Where
Philadelphia
Age
18 years and over
People
220
Run by
University of Pennsylvania
See details and how to joinNCT05056012
No phaseTaking people
Rheumatology Patient Registry and Biorepository
Where
New Haven
Age
18 years to 99 years
People
5,000
Run by
Yale University
See details and how to joinNCT04402086
No phaseTaking people
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
Where
Durham
People
1,000
Run by
Duke University
See details and how to joinNCT03276923
No phaseTaking people
The Myelin Disorders Biorepository Project
Where
Akron, Atlanta, Baltimore, Boston, Chicago, Columbus, Houston, Los Angeles, Minneapolis, Orange, Palo Alto, Philadelphia, Pittsburgh, Rochester, Sacramento, Salt Lake City, San Diego, San Francisco, Seattle, Washington D.C., Winston-Salem
People
12,000
Run by
Children's Hospital of Philadelphia
See details and how to joinNCT03047369
No phaseTaking people
Rheumatology Diet Study
Where
Orlando
Age
18 years to 65 years
People
500
Run by
University of Central Florida
See details and how to joinNCT06339957