Akut mieloid leukémia (AML): ki dolgozik rajta

Intézményenként egy kártya. Válassz célpontot, és csak az azon dolgozó csoportok maradnak.

• Minden célpont
• FLT3 36
• TP53 9
• NPM1 27
• IDH 29
• KMT2A 20
• RUNX1 2
• CD123 19
• BCL-2 10
• ABL1 2
• CD33 17
• PI3K 3
• mTOR 0
• KIT 3
• JAK 1
• CD19 8
• MAPK 0
• STAT3 0
• ERK 0
• AKT 0
• CD38 6
• HDAC 2
• MYC 1
• NRF2 0
• PD-1 4
• PPAR 0
• CXCR4 0
• BRD4 0
• PD-L1 0
• RAS 0
• STING 1
• HIF-1 0
• TIM-3 0
• METTL3 0
• CD47 1
• CTNNB1 0
• JNK 0
• KRAS 0
• MEK 0
• PARP 3
• EZH2 0
• IL-6 2
• BRAF 0
• EGFR 0
• FTO 0
• HSP90 0
• PDGFR 0
• PTEN 0
• CDK4/6 0
• FGFR 2
• GPX4 0
• HMGB1 0
• NLRP3 0
• NRAS 0
• SHP2 0
• AMPK 0
• CD20 1
• IL-15 1
• MDM2 0
• PINK1 0
• PKM2 0

1932 intézményből 24, a friss publikációk és a nyitott vizsgálatok szerint rendezve. Ez nem minőségi rangsor.

Funded research projects that name this disease in their title, terms or summary and have not ended yet: who is funded, where, how much and until when. Organisations only; the funder's page has the details.

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Targeting EP300/CBP in AML: from mechanistic discovery to therapeutic innovation (EPIC-AML)

  Universita Degli Studi di Parma· Parma, Olaszország· EU contribution 193 643 EUR· until 2029. aug.

• European Commission (Horizon Europe) · HORIZON-ERC

  Decoding the immuno-regulatory functions of the human bone marrow niche upon cancer cellular therapy (ImmunhOss)

  Lunds Universitet· Lund, Svédország· EU contribution 2 000 000 EUR· until 2032. jan.

  The disease is named only in the funder's project summary, not in the title.

• European Commission (Horizon Europe) · HORIZON-ERC

  Targeting bioactive lipids to overcome leukemia immune evasion and improve allogeneic hematopoietic stem cell transplantation outcomes (LIFE)

  Universitat Basel· Basel, Svájc· EU contribution 1 499 511 EUR· until 2031. dec.

• European Commission (Horizon Europe) · HORIZON-ERC

  Integrating DNA Methylation and Drug Abundance at Single-Cell Resolution to Predict Cancer Drug Sensitivity (EPI-SENSOR)

  Deutsches Krebsforschungszentrum Heidelberg· Heidelberg, Németország· EU contribution 1 499 423 EUR· until 2031. dec.

• European Commission (Horizon Europe) · HORIZON-ERC

  Perturbation-based Phosphoproteomics to Study Drug Response Heterogeneity (PerturbPhos)

  Universitatsklinikum Jena· Jena, Németország· EU contribution 1 491 735 EUR· until 2031. szept.

  The disease is named only in the funder's project summary, not in the title.

5 of 26 running projects, newest first. Listed amounts together: 53,2 M EUR.

Sources: NIH RePORTER (U.S. National Institutes of Health, public domain) and CORDIS (European Commission, CC BY 4.0). Changes: filtered by disease, organisations matched to ROR.

Leállított, visszavont és felfüggesztett vizsgálatok, a szponzor által a regiszterben megadott okkal, szó szerint idézve.

• Leállították

  Hu8F4 in Treating Patients With Advanced Hematologic Malignancies

  NCT02530034· M.D. Anderson Cancer Center· Frissítve: 2026. nov. 4.

  “FDA Clinical Hold”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  Olutasidenib Single Plus Combo Therapy in IDH1mut AML After Induction and Consolidation

  NCT07130695· Virginia Commonwealth University· Frissítve: 2026. okt. 29.

  “Budgetary constraints”A regiszter szövege, változtatás nélkül. Forrás

• Leállították

  Efficacy and Pharmacogenomics of Cladribine Based Salvage Chemotherapy in Patients With Relapse/Refractory and Secondary Acute Myeloid Leukemia (AML) and High Risk Myelodysplastic Syndrome (MDS)

  NCT03150004· Medical College of Wisconsin· Frissítve: 2026. okt. 21.

  “No longer have funding support to complete the pharmacogenetics component.”A regiszter szövege, változtatás nélkül. Forrás

• Felfüggesztve

  Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome That Is Newly-Diagnosed, Recurrent, or Refractory

  NCT03969446· City of Hope Medical Center· Frissítve: 2026. okt. 20.

  “Accrual goal Met”A regiszter szövege, változtatás nélkül. Forrás

• Felfüggesztve

  Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia

  NCT06454409· City of Hope Medical Center· Frissítve: 2026. okt. 20.

  “resources”A regiszter szövege, változtatás nélkül. Forrás

• Felfüggesztve

  8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

  NCT05263284· City of Hope Medical Center· Frissítve: 2026. okt. 20.

  “Safety Issues, status is being updated per PI due to safety issues. Study is now Temporarily Closed to Accrual.”A regiszter szövege, változtatás nélkül. Forrás

• Felfüggesztve

  Pyronaridine in Acute Myeloid Leukemia (AML)

  NCT05291390· Armaceutica, Inc.· Frissítve: 2026. okt. 19.

  “Change of protocol”A regiszter szövege, változtatás nélkül. Forrás

• Leállították

  A Study to Investigate Natural Killer Cell Engager (SAR443579) With Different Agents in Participants With Hematological Malignancies

  NCT06508489· Sanofi· Frissítve: 2026. okt. 19.

  “Early discontinuation based on strategic sponsor decision not driven by any safety concerns”A regiszter szövege, változtatás nélkül. Forrás

• Leállították

  AZA + Venetoclax as Maintenance Therapy in Patients With AML in Remission

  NCT04062266· M.D. Anderson Cancer Center· Frissítve: 2026. okt. 16.

  “\<75% participation”A regiszter szövege, változtatás nélkül. Forrás

• Felfüggesztve

  Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

  NCT06195891· City of Hope Medical Center· Frissítve: 2026. okt. 15.

  “Timeline Adjustment”A regiszter szövege, változtatás nélkül. Forrás

Vizsgálatok, amelyek regiszteradata szerint az egyéni résztvevői adatokat (IPD) megosztják.

• Allogeneic iNKT Cell Therapy (agenT-797) After SCT

  NCT07758218· University of Wisconsin, Madison· Forrás

• National Cancer Institute "Cancer Moonshot Biobank"

  NCT04314401· National Cancer Institute (NCI)· Forrás

• Testing the Addition of an Anti-cancer Drug, Navtemadlin, to the Usual Treatments (Cytarabine and Idarubicin) in Patients With Acute Myeloid Leukemia

  NCT04190550· National Cancer Institute (NCI)· Forrás

• Testing the Addition of an Anti-cancer Drug, M3814, to the Usual Treatment (Mitoxantrone, Etoposide, and Cytarabine) for Relapsed or Refractory Acute Myeloid Leukemia

  NCT03983824· National Cancer Institute (NCI)· Forrás

• ATRN-119 in Combination With Decitabine in Patients With TP53-Mutated AML or Higher-Risk MDS

  NCT07617363· Washington University School of Medicine· Forrás

• TAK-243 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes With Increased Blasts

  NCT03816319· National Cancer Institute (NCI)· Forrás

• Phase III Study of Induction and Consolidation Chemotherapy With Venetoclax in Patients With Newly Diagnosed AML or MDS-EB-2

  NCT04628026· University of Ulm· Forrás

• Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

  NCT06317649· National Cancer Institute (NCI)· Forrás

• The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

  NCT05436418· National Cancer Institute (NCI)· Forrás

• Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

  NCT04986657· Washington University School of Medicine· Forrás

Publikációk erről a betegségről egy MeSH-módszerkifejezés szerint, például szekvenálási vagy képalkotó módszerre.

• Single-Cell Analysis 39
• Mendelian Randomization Analysis 3
• CRISPR-Cas Systems 17
• Gene Expression Profiling 85
• Sequence Analysis, RNA 6
• Whole Genome Sequencing 7
• Exome Sequencing 1
• Proteomics 28
• Metabolomics 10
• Mass Spectrometry 3
• Flow Cytometry 88
• Immunohistochemistry 14
• Liquid Biopsy 1
• Circulating Tumor DNA 3
• Xenograft Model Antitumor Assays 160
• Positron-Emission Tomography 1
• Magnetic Resonance Imaging 11
• Machine Learning 33
• Deep Learning 12
• Cohort Studies 30
• Genome-Wide Association Study 3

• Proteomics in the discovery of biomarkers of major complications after allogeneic hematopoietic cell transplantation.

  Curr Opin Hematol, 2026. aug.

• Proteomic characterization of human kinases across tissue types: Implications for kinase-activated drugs.

  Drug Metab Dispos, 2026. aug.

• Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.

  Cells, 2026. aug.

• Novel CDK-independent function of CDC25 phosphatases in mRNA translation.

  EMBO Rep, 2026. júl.

• TCA-controlled histone succinylation identifies IDH3B as a prognostic and therapeutic target in AML.

  Clin Epigenetics, 2026. júl.

• Proteomics in Acute Myeloid Leukemia: Current Applications in Precision Medicine and Targeted Immunotherapy.

  Technol Cancer Res Treat, 2026. jún.

• A dataset supporting Combinatorial Proteome Integral Solubility/Stability Alteration Analysis (CoPISA).

  Sci Data, 2026. jún.

• Proteomics in myelodysplastic syndromes: towards novel prognostic and diagnostic biomarkers.

  Biochem Med (Zagreb), 2026. jún.

• A Minimally Invasive, Extracellular Vesicle-Based Approach for Monitoring Measurable Residual Disease in Acute Myeloid Leukemia: A Proof-of-Concept Study.

  Cells, 2026. jún.

• Organelle proteomics reveals novel metabolic vulnerabilities in FLT3-ITD cells.

  Leukemia, 2026. jún.

Megmutatjuk, a betegség mely célpontjait említi az absztrakt, és onnan a rajtuk dolgozókhoz jutsz.