Akut mieloid leukémia (AML): ki dolgozik rajta

Intézményenként egy kártya. Célpontra vagy országra szűkítheted a listát.

• Minden célpont
• FLT3 36
• TP53 9
• NPM1 27
• IDH 29
• KMT2A 20
• RUNX1 2
• CD123 19
• BCL-2 10
• ABL1 2
• CD33 17
• PI3K 3
• mTOR 0
• KIT 3
• JAK 1
• CD19 8
• MAPK 0
• STAT3 0
• ERK 0
• AKT 0
• CD38 6
• HDAC 2
• MYC 1
• NRF2 0
• PD-1 4
• PPAR 0
• CXCR4 0
• BRD4 0
• PD-L1 0
• RAS 0
• STING 1
• HIF-1 0
• TIM-3 0
• METTL3 0
• CD47 1
• CTNNB1 0
• JNK 0
• KRAS 0
• MEK 0
• PARP 3
• EZH2 0
• IL-6 2
• BRAF 0
• EGFR 0
• FTO 0
• HSP90 0
• PDGFR 0
• PTEN 0
• CDK4/6 0
• FGFR 2
• GPX4 0
• HMGB1 0
• NLRP3 0
• NRAS 0
• SHP2 0
• AMPK 0
• CD20 1
• IL-15 1
• MDM2 0
• PINK1 0
• PKM2 0

82+ intézményből 24, a friss publikációk és a nyitott vizsgálatok szerint rendezve. Ez nem minőségi rangsor.

Funded research projects that name this disease in their title, terms or summary and have not ended yet: who is funded, where, how much and until when. Organisations only; the funder's page has the details.

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Targeting EP300/CBP in AML: from mechanistic discovery to therapeutic innovation (EPIC-AML)

  Universita Degli Studi di Parma· Parma, Olaszország· EU contribution 193 643 EUR· until 2029. aug.

• European Commission (Horizon Europe) · HORIZON-ERC

  Decoding the immuno-regulatory functions of the human bone marrow niche upon cancer cellular therapy (ImmunhOss)

  Lunds Universitet· Lund, Svédország· EU contribution 2 000 000 EUR· until 2032. jan.

  The disease is named only in the funder's project summary, not in the title.

• European Commission (Horizon Europe) · HORIZON-ERC

  Targeting bioactive lipids to overcome leukemia immune evasion and improve allogeneic hematopoietic stem cell transplantation outcomes (LIFE)

  Universitat Basel· Basel, Svájc· EU contribution 1 499 511 EUR· until 2031. dec.

• European Commission (Horizon Europe) · HORIZON-ERC

  Integrating DNA Methylation and Drug Abundance at Single-Cell Resolution to Predict Cancer Drug Sensitivity (EPI-SENSOR)

  Deutsches Krebsforschungszentrum Heidelberg· Heidelberg, Németország· EU contribution 1 499 423 EUR· until 2031. dec.

• European Commission (Horizon Europe) · HORIZON-ERC

  Perturbation-based Phosphoproteomics to Study Drug Response Heterogeneity (PerturbPhos)

  Universitatsklinikum Jena· Jena, Németország· EU contribution 1 491 735 EUR· until 2031. szept.

  The disease is named only in the funder's project summary, not in the title.

5 of 26 running projects, newest first. Listed amounts together: 53,2 M EUR.

Sources: NIH RePORTER (U.S. National Institutes of Health, public domain) and CORDIS (European Commission, CC BY 4.0). Changes: filtered by disease, organisations matched to ROR.

Leállított, visszavont és felfüggesztett vizsgálatok, a szponzor által a regiszterben megadott okkal, szó szerint idézve.

• Leállították

  A Study of CG-806 in Patients With Relapsed or Refractory AML or Higher-Risk MDS

  NCT04477291· Aptose Biosciences Inc.· Frissítve: 2025. márc. 7.

  “Change in corporate strategy”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  Induction Therapy for Patients With FLT3 Mutated Acute Myeloid Leukemia

  NCT04982354· Guenther Koehne· Frissítve: 2024. okt. 1.

  “Could not accrue”A regiszter szövege, változtatás nélkül. Forrás

• Leállították

  A Study to Evaluate Lanraplenib (LANRA) in Combination With Gilteritinib in Participants With FLT3-mutated Relapsed or Refractory Acute Myeloid Leukemia (AML)

  NCT05028751· Kronos Bio· Frissítve: 2024. aug. 7.

  “Sponsor decision”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AML

  NCT03904069· Amgen· Frissítve: 2023. jún. 12.

  “Following a recent cellular therapy strategy assessment, Amgen has decided to cancel study 20180091.”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  GM-CLAG in Relapsed/Refractory FLT3-mutated AML

  NCT05330377· Ayman H Qasrawi· Frissítve: 2023. ápr. 25.

  “Sponsor withdrew funding”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic Malignancies

  NCT05279859· Erasca, Inc.· Frissítve: 2022. jún. 15.

  “Sponsor decision.”A regiszter szövege, változtatás nélkül. Forrás

• Visszavonták

  Daunorubicin or Idarubicin With Cytarabine Plus Quizartinib vs Physician's Choice in Newly Diagnosed FLT3-ITD+ AML

  NCT04676243· University Hospital Heidelberg· Frissítve: 2022. máj. 25.

  “Study turned out no longer feasible”A regiszter szövege, változtatás nélkül. Forrás

Vizsgálatok, amelyek regiszteradata szerint az egyéni résztvevői adatokat (IPD) megosztják.

• Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

  NCT06317649· National Cancer Institute (NCI)· Forrás

• A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)

  NCT05756777· Memorial Sloan Kettering Cancer Center· Forrás

• Testing the Investigational Medication Combination of Azacitidine, Venetoclax, and Quizartinib Compared to the Usual Treatment of Cytarabine, Daunorubicin, and Quizartinib for Patients With FLT3-ITD Mutant Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

  NCT07862517· National Cancer Institute (NCI)· Forrás

• A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase 3 (FLT3) Mutation

  NCT03182244· Astellas Pharma Inc· Forrás

• Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

  NCT06824168· Daiichi Sankyo· Forrás

• A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia

  NCT05520567· Astellas Pharma Global Development, Inc.· Forrás

• A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy

  NCT02752035· Astellas Pharma Global Development, Inc.· Forrás

• A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML

  NCT03591510· Novartis Pharmaceuticals· Forrás

• Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

  NCT06578247· Daiichi Sankyo· Forrás

• Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

  NCT03793478· Daiichi Sankyo· Forrás

Publikációk erről a betegségről egy MeSH-módszerkifejezés szerint, például szekvenálási vagy képalkotó módszerre.

• Single-Cell Analysis 39
• Mendelian Randomization Analysis 3
• CRISPR-Cas Systems 17
• Gene Expression Profiling 85
• Sequence Analysis, RNA 6
• Whole Genome Sequencing 7
• Exome Sequencing 1
• Proteomics 28
• Metabolomics 10
• Mass Spectrometry 3
• Flow Cytometry 88
• Immunohistochemistry 14
• Liquid Biopsy 1
• Circulating Tumor DNA 3
• Xenograft Model Antitumor Assays 160
• Positron-Emission Tomography 1
• Magnetic Resonance Imaging 11
• Machine Learning 33
• Deep Learning 12
• Cohort Studies 30
• Genome-Wide Association Study 3

• Computational deconvolution of drug sensitivity via single-cell-to-bulk transcriptome mapping.

  PLoS Comput Biol, 2026. okt.

• Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia.

  Nat Commun, 2026. okt.

• Unifying multimodal single-cell data with a mixture-of-experts β-variational autoencoder framework.

  Genome Res, 2026. okt.

• Integrative single-cell and bulk transcriptomics define polyamine-associated cell states in acute myeloid leukemia and implicate CCT6A in polyamine homeostasis.

  Front Immunol, 2026. szept.

• Single-cell chromatin profiling reveals relapse-related priming in pediatric acute myeloid leukemia.

  Life Sci Alliance, 2026. aug.

• Inhibition of high CXCR4 with motixafortide and absence of single-cell MRD predict outcome after AML consolidation.

  Blood, 2026. júl.

• Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML.

  Blood Adv, 2026. júl.

• Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia.

  Nature, 2026. júl.

• Quantitative single-cell analysis of PML-RARα oncogene-induced DNA damage along cell cycle progression.

  Methods, 2026. júl.

• Single-cell RNA sequencing reveals immunological heterogeneity of the tumor microenvironment in acute myeloid leukemia.

  Adv Clin Exp Med, 2026. júl.

Megmutatjuk, a betegség mely célpontjait említi az absztrakt, és onnan a rajtuk dolgozókhoz jutsz.