Multiple sclerosis: trials for referral
620 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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400 trials shown · Showing the 400 most recently updated of 620 open trials.
Phase 3155 sites
RecruitingAustria, Australia, Belgium, Bulgaria, Czechia, Germany
NCT07067463
A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis
Zenas BioPharma (USA), LLC
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT07066137
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
IRCCS Centro Neurolesi Bonino Pulejo
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingUnited States
NCT07914257
Treatment of Memory Retrieval Impairments in MS With HDtDCS to the LIFG in a Placebo Controlled Trial
The University of Texas at Dallas
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase6 sites
RecruitingFrance
NCT07292480
Monthly Monitoring of Plasma NfL in Treated Relapsing-remitting Multiple Sclerosis to Detect Persistent Infraclinical Disease Activity
Centre Hospitalier Universitaire de Nīmes
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase2 sites
RecruitingUnited States
NCT07376772
Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
University of Florida
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07738978
Understanding and Enhancing Human Health and Movement
Louis Stokes VA Medical Center
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
Recruiting
NCT07815990
Aerobic Fitness in Multiple Sclerosis: The Relationship Between Balance and Sensory Dual-Tasking
Suleyman Demirel University
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06951919
HOBSCOTCH-MS-Efficacy Trial
Dartmouth-Hitchcock Medical Center
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase2 sites
RecruitingCzechia, Slovenia
NCT07827586
Non-interventional Study of Subcutaneous Ocrelizumab in Persons With Relapsing-Remitting Multiple Sclerosis
Hoffmann-La Roche
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT07625800
Switch to Ofatumumab and Level of Immunoglobulins
University Hospital, Lille
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 222 sites
RecruitingCzechia, Germany, Poland
2024-517745-14-00
Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants with Multiple Sclerosis Spasticity
Celgene Corp.
Registry updated 30 Oct 2026
Registry record: EU CTISNo phase104 sites
RecruitingUnited Kingdom, Puerto Rico, United States
NCT06433752
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
TG Therapeutics, Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 48 sites
RecruitingPuerto Rico, United States
NCT07609719
A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
Genentech, Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 27 sites
RecruitingUnited States
NCT07840326
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
Sundance Biosciences, Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07615725
Dry Needling in Multiple Sclerosis
University of South Florida
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govPhase 230 sites
RecruitingGeorgia, North Macedonia, Poland, Serbia, Ukraine
NCT07503873
A Study to Evaluate Pharmacokinetics (PK) and Safety of Subcutaneous (SC) Ublituximab Administered at Various Injection Sites and Relative Bioavailability Via Autoinjector (AI) Versus Syringe Subcutaneously in Participants With Multiple Sclerosis (MS)
TG Therapeutics, Inc.
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govPhase 2/39 sites
RecruitingPoland, Slovakia, United States
NCT07220252
Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis
TG Therapeutics, Inc.
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06433765
A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
TG Therapeutics, Inc.
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT01730131
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
National Institute of Neurological Disorders and Stroke (NINDS)
Registry updated 29 Oct 2026
Registry record: ClinicalTrials.govNo phase5 sites
Not yet recruitingFrance
NCT07902479
Neurogenetics and Multi-omics of Neuroinflammatory Diseases in Multiplex Families to Improve Patients Health
Institut National de la Santé Et de la Recherche Médicale, France
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 22 sites
RecruitingUnited States
NCT06453694
Efgartigimod for the Treatment of Acute Optic Neuritis
Anastasia Vishnevetsky, MD, MPH
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 368 sites
RecruitingAustria, Belgium, Bulgaria, Czechia, Germany, Denmark
2023-504358-36-00
Efficacy and safety study of frexalimab (SAR441344) in adults with relapsing forms of multiple sclerosis
Sanofi-Aventis Recherche & Developpement
Registry updated 28 Oct 2026 · The registries disagree on the status
Registry record: EU CTISPhase 357 sites
RecruitingBulgaria, Germany, France, Peru, Russia, Ukraine
NCT06675955
An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment
Hoffmann-La Roche
Registry updated 28 Oct 2026
Registry record: ClinicalTrials.govPhase 3171 sites
RecruitingAustria, Australia, Belgium, Bulgaria, Czechia, Germany
NCT07299019
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Zenas BioPharma (USA), LLC
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT05754593
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
University Hospital, Bordeaux
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 261 sites
RecruitingAustralia, Canada, Czechia, Germany, Poland, Puerto Rico
NCT06782490
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Celgene
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruiting
NCT07899411
Evaluation of the Effect of Mental Imagery Training Combined With Modified Constraint-Induced Movement Therapy in Individuals With Multiple Sclerosis
Hacettepe University
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govNo phase3 sites
RecruitingUnited Kingdom
NCT07899502
REAL-MS: Observational Database Study of AHSCT and MS Therapies
Imperial College London
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govPhase 18 sites
RecruitingUnited States
NCT06680037
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
TG Therapeutics, Inc.
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited Arab Emirates
NCT07898371
A Study to Describe Multiple Sclerosis Patients Treated With Tolebrutinib as Per Label in a Real-world Setting
Sanofi
Registry updated 27 Oct 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States143 open trials
- France44 open trials
- Italy32 open trials
- Spain29 open trials
- Germany27 open trials
- Poland19 open trials
- United Kingdom19 open trials
- China19 open trials
- Belgium15 open trials
- Czechia14 open trials
- Portugal14 open trials
- Denmark14 open trials
- Canada14 open trials
- Switzerland13 open trials
- Greece12 open trials
- Australia12 open trials
- Bulgaria9 open trials
- Romania9 open trials
- Slovakia9 open trials
- Sweden9 open trials
- Netherlands8 open trials
- Croatia8 open trials
- Hungary7 open trials
- Austria6 open trials
- Finland6 open trials
- Slovenia5 open trials
- Lithuania5 open trials
- United Arab Emirates5 open trials
- Ukraine4 open trials
- Estonia4 open trials
- Puerto Rico4 open trials
- Brazil4 open trials
- Serbia3 open trials
- Georgia3 open trials
- Argentina3 open trials
- Norway3 open trials
- Mexico3 open trials
- Egypt3 open trials
- South Africa2 open trials
- Israel2 open trials
- Latvia2 open trials
- Luxembourg2 open trials
- Ireland2 open trials
- North Macedonia1 open trials
- Peru1 open trials
- Russia1 open trials
- Japan1 open trials
- India1 open trials
- New Zealand1 open trials
- Taiwan1 open trials
- Algeria1 open trials
- Saudi Arabia1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Amsterdam UMC Location Vrije Universiteit Amsterdam
Amsterdam, Netherlands
1 trials · 170 publications · ROR
Biomedical Research Networking Center on Neurodegenerative Diseases
Madrid, Spain
0 trials · 75 publications · ROR
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
0 trials · 64 publications · ROR
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Madrid, Spain
0 trials · 64 publications · ROR
National Hospital for Neurology and Neurosurgery
London, United Kingdom
2 trials · 175 publications · ROR
National Institute for Health and Care Research
London, United Kingdom
0 trials · 82 publications · ROR
National Institute of Neurological Disorders and Stroke
Bethesda, United States
1 trials · 92 publications · ROR
The University of Texas Health Science Center at Houston
Houston, United States
4 trials · 70 publications · ROR
The University of Texas Southwestern Medical Center
Dallas, United States
0 trials · 114 publications · ROR
University at Buffalo, State University of New York
Buffalo, United States
3 trials · 130 publications · ROR
University Medical Center of the Johannes Gutenberg University Mainz
Mainz, Germany
1 trials · 64 publications · ROR
University of California, San Francisco
San Francisco, United States
16 trials · 301 publications · ROR
University of North Carolina at Chapel Hill
Chapel Hill, United States
1 trials · 64 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Phase changed: No phase → Phase 2/3
A Long-Term Follow-Up Study for Participants Previously Treated With KYV-101
NCT07403188 · Phase 2/3 · Germany, United States
Source: ClinicalTrials.govPhase changed: No phase → Phase 4
Effect of Cladribine Treatment on Microglial Activation in the CNS
NCT04239820 · Phase 4 · Finland
Source: ClinicalTrials.govClosed for recruitment
Mastication, Cognition, and Nutritional Status in Multiple Sclerosis
NCT07411924 · No phase
Source: ClinicalTrials.govClosed for recruitment
Serum GFAP, NfL, VEGF and Clinical Progression in Progressive MS
NCT07535242 · No phase
Source: ClinicalTrials.govClosed for recruitment
Chewing Under Dual-Tasking in MS
NCT07366216 · No phase
Source: ClinicalTrials.govOpened for recruitment
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
NCT07066137 · No phase · Italy
Source: ClinicalTrials.gov
New reviews, guidelines and randomised trials in PubMed
Systematic review
Neurosurgical review · PubMed
Meta-analysis
BMC neurology · PubMed
Systematic review
Frontiers in neuroimaging · PubMed
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 29 Oct 2026
Completed86 participants
NCT07411924
Mastication, Cognition, and Nutritional Status in Multiple Sclerosis
No phaseEnded 19 Oct 2026
No phaseEnded 1 Oct 2026
No phaseEnded 18 Sept 2026
Completed28 participants
NCT05835622
Clinical Investigation of the Quality of Life Benefit of Using a Home Walking Exoskeleton for a Population of Multiple Sclerosis Patients.
No phaseEnded 15 Sept 2026
Completed77 participants
NCT07466823
Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients With Multiple Sclerosis
No phaseEnded 13 Sept 2026
Completed24 participants
NCT07028879
Effectiveness of a One-year Group Program for Fatigue Management in Minimally Impaired People With Multiple Sclerosis
Phase 1Ended 10 Sept 2026
Completed26 participants
2026-525208-90-00
A Phase 1, drug-drug interaction trial of IMU-838 with oral contraceptives in women
No phaseEnded 10 Sept 2026
Completed238 participants
NCT06587828
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
No phaseEnded 3 Sept 2026
Completed14 participants
NCT07550699
Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton
No phaseEnded 1 Sept 2026
Completed40 participants
NCT07680049
The Mediating Role of Balance in the Relationship Between Fatigue and Fear of Falling in Individuals With Multiple Sclerosis
No phaseEnded 1 Sept 2026
Completed75 participants
NCT07037966
Advancing Portable Brain Imaging: The NextMRI Project's Role in Revolutionizing Diagnostic MRI
No phaseEnded 31 Aug 2026
Completed11 participants
NCT07687693
Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis
No phaseEnded 31 Aug 2026
Completed900 participants
NCT03500328
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial
No phaseEnded 29 Aug 2026
Completed28 participants
NCT06595394
Effect of Combined Exercise Training in Patients With Multiple Sclerosis
No phaseEnded 12 Aug 2026
Completed60 participants
NCT06957145
Vista Protein Expression of Monocyte and T Cell Subsets in Multiple Sclerosis and Its Clinical Correlation
No phaseEnded 12 Aug 2026
Completed45 participants
NCT06800144
Effect of Music Therapy on Pain in People With Multiple Sclerosis
- Effect of Telerehabilitation-Based Music Therapy and Motor Imagery on Pain, Autonomic Function, and Psychosocial Outcomes in People With Multiple Sclerosis: A Randomized Controlled Trial Protocol. · Physiotherapy research international : the journal for researchers and clinicians in physical therapy, 2026
No phaseEnded 30 Jul 2026
Completed20 participants
NCT07831239
Association Between Peripheral Immune Biomarkers and Functional Performance in Multiple Sclerosis
No phaseEnded 30 Jul 2026
Completed50 participants
NCT05469568
Hybrid Rehabilitation Approach Through Group Exercise and Telerehabilitation in Patients With Multiple Sclerosis
No phaseEnded 29 Jul 2026
Completed46 participants
NCT04116424
VIGIP-SEP2: Training of Patients by Nurses on ADR Reporting by RRMS Patient Via an App
No phaseEnded 28 Jul 2026
Completed10 participants
NCT07663266
Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord Injury
No phaseEnded 28 Jul 2026
No phaseEnded 22 Jul 2026
Completed120 participants
NCT07507331
Turkish Version of the Neurogenic Bladder Symptom Score Short Form
No phaseEnded 20 Jul 2026
Completed38 participants
NCT07390201
Effect of Sensory Integration Therapy on Gait Variability and Quality Of Life in Patients With Multiple Sclerosis
Phase 3Ended 3 Jul 2026
Completed145 participants
2024-516672-16-00
A 96-Week, Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study to Compare Efficacy and Safety of Masitinib Dose Titration to 4.5 mg/kg/day versus Placebo in the Treatment of Patients with Primary Progressive or Secondary Progressive Multiple Sclerosis Without Relapse
Phase 2Ended 30 Jun 2026
Completed90 participants
2024-515470-26-00
No Evidence Of Disease Activity After Autologous Haematopoietic Stem Cell Transplantation In Aggressive Multiple Sclerosis
No phaseEnded 30 Jun 2026
Completed60 participants
NCT07269054
Effects of Home-based Respiratory Muscle Training With New Load Adjustment Test in People With Multiple Sclerosis
No phaseEnded 30 Jun 2026
No phaseEnded 30 Jun 2026
No phaseEnded 30 Jun 2026
No phaseEnded 22 Jun 2026
Completed39 participants
NCT07461987
Tai Chi and Square-Stepping Exercises in Women With Multiple Sclerosis
No phaseEnded 1 Jun 2026
No phaseEnded 1 Jun 2026
Completed300 participants
NCT07889271
Hand Grip Strength Correlates Strongly With Weekly Working Hours - the Importance of Upper Limb Function in Multiple Sclerosis
No phaseEnded 30 May 2026
No phaseEnded 29 May 2026
Completed19 participants
NCT06921551
Exploratory Pilot Study on the Prolonged Use of the ABLE Exoskeleton in Multiple Sclerosis
No phaseEnded 25 May 2026
Completed150 participants
NCT02454907
The Use of Technology to Improve MS Clinical Trials and Patient Care
No phaseEnded 22 May 2026
Completed196 participants
NCT05286242
Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients
No phaseEnded 10 May 2026
Completed30 participants
NCT07331350
Exercise Balance Program for Fall Prevention in Multiple Sclerosis
No phaseEnded 5 May 2026
No phaseEnded 1 May 2026
Completed39 participants
NCT07726667
Effects of CTAR and PNF Exercises on Swallowing in Multiple Sclerosis
No phaseEnded 30 Apr 2026
Completed261 participants
NCT07504783
A Study to Evaluate the Real-world Experience and Satisfaction Associated With Ofatumumab
No phaseEnded 30 Apr 2026
Completed40 participants
NCT07233044
Effect of Visually-Guided Gait Training on Balance, Mobility and Risk of Falling in Patients With Multiple Sclerosis
No phaseEnded 30 Apr 2026
Completed36 participants
NCT07624812
Behavioral and Electrophysiological Evidence of the Modulation of Fatigue in RR-MS
Phase 1/2Ended 27 Apr 2026
Completed15 participants
NCT05168384
Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis
No phaseEnded 27 Apr 2026
Completed62 participants
NCT06922942
MSCopilot Users' Feedback in Real Life - Outcomes Regarding Integration in Patients' pathWay and Users' ExpeRience
No phaseEnded 24 Apr 2026
No phaseEnded 17 Apr 2026
Completed76 participants
NCT07063810
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
No phaseEnded 15 Apr 2026
Completed66 participants
NCT03455582
Cognition Evolution and MRI Markers in PPMS Patients on 2 Years
- Interthalamic adhesion alterations in multiple sclerosis: associations with thalamic damage and cognition. · Journal of neurology, 2026
No phaseEnded 14 Apr 2026
Phase 1Ended 8 Apr 2026
No phaseEnded 2 Apr 2026
No phaseEnded 1 Apr 2026
Phase 1/2Ended 31 Mar 2026
No phaseEnded 31 Mar 2026
Completed12 participants
NCT06264336
Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
Phase 2Ended 28 Mar 2026
Completed16 participants
NCT07840924
The CanISleepinMS Study: Effect of Cannabidiol (CBD) on Sleep Quality in Patients With Multiple Sclerosis
No phaseEnded 18 Mar 2026
Completed200 participants
NCT06283524
Eye-tracking Investigation of Clinical Measures in Multiple Sclerosis
No phaseEnded 16 Mar 2026
Completed293 participants
NCT07195110
Prevalence of Periodontitis in Egyptian Multiple Sclerosis Patients.
No phaseEnded 15 Mar 2026
No phaseEnded 3 Mar 2026
No phaseEnded 28 Feb 2026
Completed361 participants
NCT06403631
Supporting Mental Health in Daily Life After the Diagnosis of Multiple Sclerosis
No phaseEnded 28 Feb 2026
Not medical advice. fetched 4 Nov 2026