Polycystic kidney disease: trials for referral
47 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
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47 trials shown
No phase1 site
RecruitingUnited States
NCT06325644
Well-Formulated Ketogenic Diet Polycystic Kidney Disease
Ohio State University
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 10 sites
Not yet recruiting
NCT07909070
A Study to Investigate the Pharmacokinetics of JMKX003142 in Healthy Participants and Participants With Hepatic Impairment
Jemincare
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 322 sites
RecruitingBelgium, Germany, Spain, United Kingdom, Poland, United States
NCT04782258
A Study to See if Tolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old With Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govEarly Phase 11 site
Not yet recruitingChina
NCT07891364
GBP-213 in Patients With Autosomal Dominant Polycystic Kidney Disease
RenJi Hospital
Registry updated 23 Oct 2026
Registry record: ClinicalTrials.govPhase 115 sites
RecruitingChina, United Kingdom, United States
NCT07228364
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
AstraZeneca
Registry updated 13 Oct 2026
Registry record: ClinicalTrials.govPhase 291 sites
RecruitingAustralia, Belgium, Canada, Germany, Spain, France
NCT06902558
ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Calico Life Sciences LLC
Registry updated 6 Oct 2026 · The registries disagree on the status
Registry record: ClinicalTrials.govPhase 11 site
RecruitingCanada
NCT07792408
Effects of VX-407 on the Pharmacokinetics of Combined Oral Contraceptives
Vertex Pharmaceuticals Incorporated
Registry updated 30 Sept 2026
Registry record: ClinicalTrials.govPhase 23 sites
RecruitingUnited States
NCT07282821
Bempedoic Acid Therapy for Polycystic Kidney Disease
Kenneth Hallows
Registry updated 29 Sept 2026
Registry record: ClinicalTrials.govPhase 325 sites
RecruitingAustria, Belgium, Switzerland, Germany, Spain, France
NCT05373264
HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life
University Medical Center Groningen
Registry updated 25 Aug 2026
Registry record: ClinicalTrials.govPhase 330 sites
RecruitingAustria, Germany, Spain, Netherlands
NCT07280585
STOP-PKD: SGLT2-inhibition to Improve Prognosis in Polycystic Kidney Disease
University of Cologne
Registry updated 28 Jul 2026
Registry record: ClinicalTrials.govPhase 112 sites
RecruitingAustralia, Hong Kong, New Zealand
NCT06714006
Phase 1 Study to Evaluate the Safety and Tolerability of Intravenously Administered PYC-003
PYC Therapeutics
Registry updated 27 Jul 2026
Registry record: ClinicalTrials.govPhase 349 sites
RecruitingAustralia, United Kingdom, New Zealand
NCT04939935
Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)
The University of Queensland
Registry updated 31 Mar 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingChina
NCT06800651
Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Jemincare
Registry updated 3 Jul 2025
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT06582875
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
University of Colorado, Denver
Registry updated 6 May 2025
Registry record: ClinicalTrials.govPhase 23 sites
By invitation onlyTaiwan
NCT05870007
Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
Taipei Medical University Shuang Ho Hospital
Registry updated 23 May 2023
Registry record: ClinicalTrials.govPhase 22 sites
RecruitingNetherlands
NCT05478083
A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease
University Medical Center Groningen
Registry updated 4 Nov 2022
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited Kingdom
NCT07260071
Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
King's College London
Registry updated 4 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders
Assistance Publique - Hôpitaux de Paris
Registry updated 21 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT04039061
ADPKD Patient Registry
PKD Foundation
Registry updated 22 Sept 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT07745920
Managing Depressive Symptoms in ADPKD
Mayo Clinic
Registry updated 7 Aug 2026
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT07651397
Dietary Modulation of Urinary MCP-1 in ADPKD
Assaf-Harofeh Medical Center
Registry updated 26 Jun 2026
Registry record: ClinicalTrials.govNo phase4 sites
RecruitingUnited States
NCT04338048
Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study
Children's Hospital of Philadelphia
Registry updated 15 Jun 2026
Registry record: ClinicalTrials.govNo phase6 sites
RecruitingUnited States
NCT01401998
ARPKD Database Study
Children's Hospital of Philadelphia
Registry updated 15 Jun 2026
Registry record: ClinicalTrials.govPhase 24 sites
RecruitingFrance
NCT06291116
Safety of RotigotiNe in Patients With Autosomal Dominant Polycystic Kidney Disease
University Hospital, Rouen
Registry updated 9 Jun 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingDenmark
2024-512491-35-00
Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI
Aarhus Universitet
Registry updated 3 Jun 2026
Registry record: EU CTISNo phase12 sites
RecruitingGermany
NCT02497521
The German ADPKD Tolvaptan Treatment Registry
University of Cologne
Registry updated 30 Apr 2026
Registry record: ClinicalTrials.govNo phase3 sites
RecruitingUnited States
NCT02936791
Early PKD Observational Cohort Study
University of Kansas Medical Center
Registry updated 27 Apr 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT07535385
RADIOLOGICAL AND CLINICAL EVALUATION OF RENAL EMBOLIZATION USING EVOH IN DIALYSIS PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A PROSPECTIVE LONGITUDINAL OBSERVATIONAL STUDY
Fondazione IRCCS Policlinico San Matteo di Pavia
Registry updated 17 Apr 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingItaly
NCT05996731
Developing a Pipeline to Employ RNA-Seq as a Complementary Diagnostic Tool in Rare Diseases
Mario Negri Institute for Pharmacological Research
Registry updated 23 Mar 2026
Registry record: ClinicalTrials.govPhase 315 sites
RecruitingItaly
NCT03764605
Metformin versus Tolvaptan in adults with Autosomal Dominant Polycystic Kidney Disease (ADPKD): a phase 3a, independent, multi-centre, 2 parallel arms randomized controlled trial
University Of Bari Aldo Moro
Registry updated 10 Mar 2026
Registry record: EU CTIS
The same sites as a list
- United States21 open trials
- Italy6 open trials
- Germany5 open trials
- United Kingdom5 open trials
- Belgium4 open trials
- Spain4 open trials
- China4 open trials
- France4 open trials
- Netherlands4 open trials
- Canada3 open trials
- Australia3 open trials
- South Korea2 open trials
- Austria2 open trials
- New Zealand2 open trials
- Poland1 open trial
- Japan1 open trial
- Portugal1 open trial
- Switzerland1 open trial
- Hong Kong1 open trial
- Taiwan1 open trial
- Denmark1 open trial
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
The University of Texas Southwestern Medical Center
Dallas, United States
1 trial · 11 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Closed for recruitment
Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
NCT07161037 · Phase 2 · Belgium, Canada, Germany, Spain, France, United Kingdom
Source: ClinicalTrials.govOpened for recruitment
NCT06902558 · Phase 2 · Australia, Belgium, Canada, Germany, Spain, France
Source: ClinicalTrials.govClosed for recruitment
NCT06902558 · Phase 2 · Australia, Belgium, Canada, Germany, Spain, France
Source: ClinicalTrials.govOpened for recruitment
Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
NCT07161037 · Phase 2 · Belgium, Canada, Germany, Spain, France, United Kingdom
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
No phaseEnded 31 Dec 2025
Completed530 participants
NCT02925221
Canadian Medical Assessment of JINARC™ Outcomes Registry
- Eight Years of Canadian Real-World Assessment of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease: The C-MAJOR Registry. · Canadian journal of kidney health and disease, 2026
No phaseEnded 11 Dec 2025
Phase 2Ended 8 Dec 2025
Phase 2Ended 1 Dec 2025
Completed16 participants
NCT06435858
Short-term Effects of an SGLT2 Inhibitor on Divalent Ions in Autosomal Dominant Polycystic Kidney Disease
No phaseEnded 31 Oct 2025
Completed10 participants
NCT06594367
A Possible Founding PKD2 Mutation Associated With Variable Phenotypes of ADPKD in Bergamo Province
Phase 3Ended 1 Sept 2025
Phase 2Ended 4 Aug 2025
Completed1 participant
NCT04284657
Pravastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
Phase 4Ended 18 Jun 2025
No phaseEnded 6 May 2025
Phase 1Ended 27 Mar 2025
Completed68 participants
NCT05521191
A Study of RGLS8429 in Patients With Autosomal Dominant Polycystic Kidney Disease
- Emerging Therapies in Autosomal Dominant Polycystic Kidney Disease. · Kidney360, 2026
- Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease. · American journal of physiology. Renal physiology, 2026
No phaseEnded 10 Dec 2024
No phaseEnded Apr 2024
No phaseEnded 25 Mar 2024
Completed91 participants
NCT05646420
Thyroid Hormones in ADPKD
- Thyroid Hormones Exhibit Promising Prognostic and Therapeutic Potential in Autosomal Dominant Polycystic Kidney Disease. · Thyroid : official journal of the American Thyroid Association, 2026
No phaseEnded 11 Mar 2024
Completed594 participants
NCT02173080
Development and Assessment of The Polycystic Liver Disease Questionnaire (PLD-Q).
Not medical advice. fetched 11 Nov 2026