Hospital for Sick Children

Running trials

• Not yet recruiting

  A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex

  NCT06924827· Phase 4· Elizabeth Donner· Source

• Not yet recruiting

  COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

  NCT07281027· Phase 3· Yale University· Source

• Recruiting

  Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype

  NCT07282210· Phase 2· Biossil Inc.· Source

• Not yet recruiting

  Optimizing Care Transitions in CHD

  NCT07898384· The Hospital for Sick Children· Source

• Enrolling by invitation

  3D Ultrasound in Hemophilic Ankles

  NCT07452575· The Hospital for Sick Children· Source

• Recruiting

  MedlyPeds Feasibility Study

  NCT07556185· The Hospital for Sick Children· Source

• Recruiting

  A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

  NCT07192952· Phase 3· Bayer· Source

• Not yet recruiting

  CPAP vs High-Flow Nasal Cannula for Treating Sleep Apnea in Children

  NCT07600333· The Hospital for Sick Children· Source

• Not yet recruiting

  Phase I Clinical Trial of ThINKK Adoptive Immunotherapy After Allogeneic Hematopoietic Transplantation in Children With Leukemia or Neuroblastoma

  NCT07518654· Phase 1· Michel Duval· Source

• Recruiting

  A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis

  NCT07158242· Phase 3· Hoffmann-La Roche· Source

• Not yet recruiting

  MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .

  NCT07454681· The Hospital for Sick Children· Source

• Not yet recruiting

  Pain Caregiver Resource (PainCaRe)

  NCT06651190· The Hospital for Sick Children· Source

• Recruiting

  A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients

  NCT07549321· Phase 2/3· Renaissance Pharma Ltd.· Source

• Recruiting

  Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa

  NCT07213973· Phase 2· Incyte Corporation· Source

• Recruiting

  GMEB-SASS: A Gene-Modified Skin Substitute for RDEB Treatment

  NCT07193134· Phase 1/2· CHU de Quebec-Universite Laval· Source

• Recruiting

  A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

  NCT07287982· Phase 2· argenx· Source

• Active, not recruiting

  A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

  NCT07107945· Phase 3· Boehringer Ingelheim· Source

• Recruiting

  A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

  NCT06979453· Phase 3· Bristol-Myers Squibb· Source

• Not yet recruiting

  Deep Brain Stimulation vs. Vagus Nerve Stimulation for Epileptic Spasms

  NCT07010276· The Hospital for Sick Children· Source

• Recruiting

  A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction

  NCT07188805· Phase 3· Bayer· Source

• Recruiting

  The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services

  NCT06455384· Unity Health Toronto· Source

• Recruiting

  A Study of SGT-003 Gene Therapy in Ambulant Males With Duchenne Muscular Dystrophy (IMPACT DUCHENNE)

  NCT07160634· Phase 3· Solid Biosciences Inc.· Source

• Recruiting

  Magnesium Trial in Acute Asthma in Emergency Department

  NCT06785272· Phase 3· Suzanne Schuh· Source

• Recruiting

  Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

  NCT06942039· Early phase 1· C17 Council· Source

• Not yet recruiting

  The iPeer2Peer Mentorship Program for Young Adults With Heart Disease

  NCT07119216· Samantha Anthony· Source

• Recruiting

  Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

  NCT06333899· Early phase 1· Nationwide Children's Hospital· Source

• Not yet recruiting

  Three Times Weekly Symptom Screening for Children With Cancer

  NCT04275102· The Hospital for Sick Children· Source

• Recruiting

  CANnabinoids in Pediatric ONCology

  NCT05754840· Phase 1/2· University of Manitoba· Source

• Active, not recruiting

  A Study of CC-97540 (BMS-986353 or Zola-cel), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)

  NCT07015983· Phase 2· Juno Therapeutics, Inc., a Bristol-Myers Squibb Company· Source

• Recruiting

  ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

  NCT06838676· Phase 2· Nationwide Children's Hospital· Source

• Active, not recruiting

  Timely Ordering of Pharmacogenetic Testing

  NCT06902688· The Hospital for Sick Children· Source

• Recruiting

  A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

  NCT06124157· Phase 2· National Cancer Institute (NCI)· Source

• Recruiting

  A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

  NCT06941272· Phase 1/2· Merck Sharp & Dohme LLC· Source

• Recruiting

  A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

  NCT06401330· Phase 3· Children's Oncology Group· Source

• Recruiting

  Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

  NCT06647953· Phase 3· Children's Oncology Group· Source

• Active, not recruiting

  Vomiting Prevention in Children With Cancer

  NCT06886451· The Hospital for Sick Children· Source

• Recruiting

  Ziftomenib in Combination With Chemotherapy for Children With Relapsed/Refractory Acute Leukemia

  NCT06376162· Phase 1· PedAL BCU, LLC· Source

• Recruiting

  VIdeo Clips for Diagnostic Evaluation of Obstructive Sleep Apnea in Children

  NCT06801366· Children's Hospital of Eastern Ontario· Source

• Enrolling by invitation

  Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

  NCT06823115· Indiana University· Source

• Recruiting

  WeRoaM: Wearable Remote Monitoring in Heart Failure

  NCT06969560· University of Alberta· Source

• Enrolling by invitation

  A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)

  NCT06908226· Phase 3· Longboard Pharmaceuticals· Source

• Recruiting

  Study of Olutasidenib and Temozolomide in HGG

  NCT06161974· Phase 2· Rigel Pharmaceuticals· Source

• Recruiting

  A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

  NCT06548360· Phase 3· Incyte Corporation· Source

• Recruiting

  A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

  NCT06609226· Phase 3· Novo Nordisk A/S· Source

• Recruiting

  CLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies

  NCT06208735· Phase 1· British Columbia Cancer Agency· Source

• Active, not recruiting

  Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

  NCT06627179· Phase 2· Laboratoires Thea· Source

• Recruiting

  A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)

  NCT06519682· Daniel Morgenstern· Source

• Recruiting

  Avapritinib Rollover Study

  NCT06748001· Phase 4· Blueprint Medicines Corporation· Source

• Active, not recruiting

  Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older

  NCT06460506· Phase 3· Vertex Pharmaceuticals Incorporated· Source

• Active, not recruiting

  A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

  NCT06719141· Phase 3· Longboard Pharmaceuticals· Source

Showing 50 of 223.

Recruiting at the same time

How many trials recruit for the same indication here at once. A count, not a rating.

• Childhood cancers49 recruiting
• Heart failure8 recruiting
• Neuroblastoma8 recruiting
• Acute lymphoblastic leukaemia7 recruiting
• Congenital heart disease7 recruiting
• Epilepsy7 recruiting
• High blood pressure5 recruiting
• Sarcoma5 recruiting
• Acute myeloid leukaemia4 recruiting
• Crohn's disease4 recruiting
• Glioblastoma4 recruiting
• Psoriasis4 recruiting
• Sickle cell disease4 recruiting
• Brain metastases3 recruiting
• Cerebral palsy3 recruiting
• Chronic kidney disease3 recruiting
• Cystic fibrosis3 recruiting
• Haemophilia3 recruiting
• Ulcerative colitis3 recruiting
• Asthma2 recruiting
• Charcot-Marie-Tooth disease2 recruiting
• Diffuse large B-cell lymphoma2 recruiting
• Duchenne muscular dystrophy2 recruiting
• Kidney cancer2 recruiting
• Lupus (SLE)2 recruiting
• Obesity2 recruiting
• Obstructive sleep apnoea2 recruiting
• Ovarian cancer2 recruiting
• Psoriatic arthritis2 recruiting
• Pulmonary arterial hypertension2 recruiting
• Aortic stenosis1 recruiting
• Autism1 recruiting
• Burkitt lymphoma1 recruiting
• Chronic lymphocytic leukaemia1 recruiting
• Down syndrome1 recruiting
• Epidermolysis bullosa1 recruiting
• Friedreich ataxia1 recruiting
• Gastric and oesophageal cancer1 recruiting
• Hidradenitis suppurativa1 recruiting
• Liver and biliary tract cancer1 recruiting
• Mantle cell lymphoma1 recruiting
• Multiple sclerosis1 recruiting
• Myelodysplastic syndromes1 recruiting
• Nephrotic syndrome1 recruiting
• Neuromyelitis optica (NMOSD)1 recruiting
• Pancreatic cancer1 recruiting
• Retinitis pigmentosa1 recruiting
• Rheumatoid arthritis1 recruiting
• Spinal cord injury1 recruiting
• Spinal muscular atrophy1 recruiting
• Stroke1 recruiting
• Systemic sclerosis (scleroderma)1 recruiting
• Thalassaemia1 recruiting
• Type 1 diabetes1 recruiting
• Vitiligo1 recruiting

Closed trials

• Completed

  Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis (CF)

  NCT06506773· Vertex Pharmaceuticals Incorporated· Source

• Completed

  Canadian CHO-KLAT/H-FIT Study - Quality of Life of, and Burden of Caring for, Persons With Hemophilia

  NCT06191068· The Hospital for Sick Children· Source

• Terminated

  A Study Of PGN-EDO51 In Participants With Duchenne Muscular Dystrophy Amenable To Exon 51-Skipping Treatment

  NCT06079736· Phase 2· PepGen Inc· Source

• Completed

  A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Active Ulcerative Colitis

  NCT05784246· Phase 3· Eli Lilly and Company· Source

• Completed

  Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study

  NCT03710343· Phase 2· Holland Bloorview Kids Rehabilitation Hospital· Source

• Terminated

  Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

  NCT05934630· Pediatric Brain Tumor Consortium· Source

• Completed

  A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex

  NCT05864846· Phase 4· Jazz Pharmaceuticals· Source

• Completed

  Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age

  NCT05882357· Phase 3· Vertex Pharmaceuticals Incorporated· Source

• Completed

  The IPAd Study: Exploring the Association Between Insomnia and Positive Airway Pressure Adherence in Children

  NCT05949164· The Hospital for Sick Children· Source

• Recruiting

  A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease

  NCT06198712· Phase 2· Forma Therapeutics, Inc.· Source

• Completed

  Dexamethasone Treatment for OSA in Children

  NCT05638087· Phase 3· The Hospital for Sick Children· Source

• Completed

  Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure

  NCT05257525· The Hospital for Sick Children· Source

• Completed

  Research Study Investigating How Well NDec Works in People With Sickle Cell Disease

  NCT05405114· Phase 2· Novo Nordisk A/S· Source

• Completed

  A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy

  NCT05115110· Phase 2/3· Hoffmann-La Roche· Source

• Terminated

  Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors

  NCT07121829· Phase 1· Day One Biopharmaceuticals, Inc.· Source

• Completed

  Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)

  NCT05312177· Carelon Research· Source

• Completed

  EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway

  NCT05093634· Phase 3· Rhythm Pharmaceuticals, Inc.· Source

• Completed

  A Research Study Looking at Mim8 in Children With Haemophilia A With or Without Inhibitors

  NCT05306418· Phase 3· Novo Nordisk A/S· Source

• Completed

  Adjunctive GNX Treatment Compared With Placebo in Children and Adults With TSC-related Epilepsy

  NCT05323734· Phase 3· Marinus Pharmaceuticals· Source

• Completed

  A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease

  NCT04987489· Phase 2· Forma Therapeutics, Inc.· Source

• Completed

  A Study to Assess Vamorolone in Boys Ages 2 to <4 Years and 7 to <18 Years With Duchenne Muscular Dystrophy (DMD)

  NCT05185622· Phase 2· Santhera Pharmaceuticals· Source

• Terminated

  A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome

  NCT05163314· Phase 3· Takeda· Source

• Completed

  A Study of Avapritinib in Pediatric Patients With Solid Tumors Dependent on KIT or PDGFRA Signaling

  NCT04773782· Phase 1/2· Blueprint Medicines Corporation· Source

• Completed

  Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older

  NCT05153317· Phase 3· Vertex Pharmaceuticals Incorporated· Source

• Completed

  Keeping in Touch (KiT) With Youth as They Transition to Adult Type 1 Diabetes Care

  NCT05434754· The Hospital for Sick Children· Source

• Completed

  Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE

  NCT05001737· Phase 3· Swedish Orphan Biovitrum· Source

• Completed

  A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors

  NCT05053139· Phase 3· Novo Nordisk A/S· Source

• Completed

  A Study of Soticlestat as an Add-on Therapy in Children, Teenagers, and Adults With Lennox-Gastaut Syndrome

  NCT04938427· Phase 3· Takeda· Source

• Completed

  A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome

  NCT04940624· Phase 3· Takeda· Source

• Completed

  Fitness to Aid the Brain and Cognitive Skills

  NCT05367076· The Hospital for Sick Children· Source

• Withdrawn

  Breastmilk Composition and Microbial Profile in the Growth and Development of Healthy Term-born Infants

  NCT06970535· The Hospital for Sick Children· Source

• Terminated

  Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma

  NCT04751383· Phase 1· National Cancer Institute (NCI)· Source

• Recruiting

  Study of Lunresertib Alone or in Combination With RP-3500 or Zedoresertib (Debio 0123) in Patients With Advanced Solid Tumors

  NCT04855656· Phase 1· Debiopharm International SA· Source

• Completed

  Exercise, Creatine and Coenzyme Q10 for Childhood Myositis

  NCT04286178· The Hospital for Sick Children· Source

• Completed

  Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene

  NCT04671433· Phase 3· MeiraGTx Ocular UK Ltd· Source

• Completed

  Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI

  NCT04391322· The Hospital for Sick Children· Source

• Terminated

  A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome

  NCT04572243· Phase 3· Eisai Inc.· Source

• Completed

  Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus

  NCT04335643· Michigan State University· Source

• Completed

  A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease Symptoms

  NCT04435600· Phase 3· AbbVie· Source

• Completed

  HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers

  NCT04670016· University of Calgary· Source

• Completed

  A Mindfulness-Based Intervention to Improve CPAP

  NCT05499286· The Hospital for Sick Children· Source

• Completed

  Topotecan Episcleral Plaque for Treatment of Retinoblastoma

  NCT04428879· Phase 1· The Hospital for Sick Children· Source

• Completed

  Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B

  NCT03938792· Phase 3· Pfizer· Source

• Recruiting

  Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

  NCT04278404· Duke University· Source

• Completed

  Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA TC Combination Therapy in Participants With Cystic Fibrosis Who Are 6 Years of Age and Older

  NCT04183790· Phase 3· Vertex Pharmaceuticals Incorporated· Source

• Completed

  Hyperpolarized Imaging for New Treatments

  NCT04259970· Phase 4· Children's Hospital Medical Center, Cincinnati· Source

• Completed

  The Pain Squad+ Smartphone App To Support Real-Time Pain Management for Adolescents With Cancer

  NCT03632343· The Hospital for Sick Children· Source

• Completed

  Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitors BMS-986158 and BMS-986378 in Pediatric Cancer

  NCT03936465· Phase 1· Dana-Farber Cancer Institute· Source

• Completed

  Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine

  NCT03832998· Phase 3· Amgen· Source

• Completed

  Deep Brain Stimulation in Children With Autism

  NCT03982888· The Hospital for Sick Children· Source

Showing 50 of 110.

Conditions

Diseases this institution publishes on or runs trials for.

• Childhood cancers86 works · 157 trials
• Epilepsy76 works · 15 trials
• Crohn's disease59 works · 7 trials
• Cystic fibrosis51 works · 13 trials
• Congenital heart disease49 works · 14 trials
• Asthma48 works · 5 trials
• Autism46 works · 2 trials
• Acute lymphoblastic leukaemia34 works · 25 trials
• Multiple sclerosis33 works · 3 trials
• Sarcoma30 works · 22 trials
• Glioblastoma29 works · 7 trials
• Lupus (SLE)24 works · 5 trials
• Hearing loss24 works · 0 trials
• Dystonia21 works · 0 trials
• Type 1 diabetes21 works · 4 trials
• Hydrocephalus20 works · 2 trials
• Hodgkin lymphoma18 works · 3 trials
• Neurofibromatosis type 117 works · 2 trials
• Nephrotic syndrome17 works · 2 trials
• Neuroblastoma16 works · 24 trials
• Obstructive sleep apnoea16 works · 6 trials
• Down syndrome16 works · 6 trials
• Cerebral palsy13 works · 4 trials
• Sickle cell disease13 works · 10 trials
• Haemophilia11 works · 12 trials
• Alopecia areata10 works · 0 trials
• Duchenne muscular dystrophy9 works · 6 trials
• Myocarditis9 works · 0 trials
• Cytomegalovirus infection9 works · 0 trials
• Iron deficiency anaemia7 works · 0 trials