ALS (motor neurone disease) trials in United States

In United States 91 Also abroad 226

91 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Tofersen in Non-SOD1 ALS
Where
Atlanta, Boston, St Louis
Age
18 years and over
People
30
Run by
Washington University School of Medicine
See details and how to joinNCT07294144
No phaseTaking people
Healing ALS Registry Observational Study (HAROS)
Where
Park City
Age
18 years to 110 years
People
1,000
Run by
Healing Advocates Registry and Ministry
See details and how to joinNCT07233148
No phaseTaking people
Clinical Procedures to Support Research in ALS
Where
Durham, Irvine, Kansas City, Miami, Minneapolis, New York, Palo Alto, Portland, San Antonio, San Francisco, Winston-Salem
Age
18 years and over
People
1,200
Run by
University of Miami
See details and how to joinNCT03489278
Phase 2Taking people
A Study of Ranolazine in ALS
Where
Columbia, Columbus, Fairway, Jacksonville, San Francisco, Wichita
Age
18 years and over
People
72
Run by
Swathy Chandrashekhar, MBBS
See details and how to joinNCT06527222
No phaseTaking people
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
Where
Loma Linda
Age
18 years to 85 years
People
160
Run by
Loma Linda University
See details and how to joinNCT04097158
No phaseTaking people
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
Where
Boston, Stanford
Age
18 years to 80 years
People
3
Run by
Leigh R. Hochberg, MD, PhD.
See details and how to joinNCT05724173
No phaseTaking people
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Where
Atlanta, Boston, Houston, Providence, Sacramento, Stanford
Age
18 years to 80 years
People
27
Run by
Leigh R. Hochberg, MD, PhD.
See details and how to joinNCT00912041
No phaseTaking people
Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
Where
Davie
Age
18 years and over
People
10
Run by
Nova Southeastern University
See details and how to joinNCT07187388
No phaseTaking people
ALS/MND Natural History Study Data Repository
Where
Burlington, Chicago, Detroit, Gainesville, Grand Rapids, Loma Linda, Los Angeles, Minneapolis, Philadelphia, Pittsburgh, Portland, Richmond, St Louis
Age
18 years to 90 years
People
5,000 worldwide
Run by
Massachusetts General Hospital
See details and how to joinNCT05966038
No phaseTaking people
The National Amyotrophic Lateral Sclerosis Registry
Where
Atlanta
Age
18 years and over
People
30,000
Run by
Centers for Disease Control and Prevention
See details and how to joinNCT01772602
No phaseTaking people
EIM Via the Myolex mScan as an ALS Biomarker
Where
Ann Arbor, Boston, Lebanon, Phoenix, Winston-Salem
Age
18 years and over
People
80
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT06491732
Phase 1Taking people
AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
Where
Boston, Gainesville, Houston, Jacksonville, Knoxville, La Jolla, Orlando, Philadelphia, Rochester, Washington D.C.
Age
18 years and over
People
48 worldwide
Run by
Amylyx Pharmaceuticals Inc.
See details and how to joinNCT06665165
No phaseTaking people
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
Where
Ann Arbor, Boston, Sacramento
Age
22 years to 75 years
People
2
Run by
Paradromics
See details and how to joinNCT07357428
No phaseTaking people
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS)
Where
Boston
Age
18 years and over
People
125
Run by
Biogen
See details and how to joinNCT07259980
No phaseTaking people
Examining Interactions Between PALS and Caregivers
Where
University Park
Age
18 years to 90 years
People
152
Run by
Penn State University
See details and how to joinNCT06819124
No phaseTaking people
Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth
Where
Salisbury
Age
18 years and over
People
30
Run by
TidalHealth, Inc.
See details and how to joinNCT07491484
No phaseTaking people
Clinical Research in ALS Study
Where
Miami
Age
18 years and over
People
10,000
Run by
University of Miami
See details and how to joinNCT00136500
No phaseTaking people
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Where
Miami
Age
18 years and over
People
500
Run by
University of Miami
See details and how to joinNCT00317616
No phaseTaking people
Spinal Cord Associative Plasticity for ALS
Where
The Bronx
Age
18 years to 80 years
People
32
Run by
VA Office of Research and Development
See details and how to joinNCT06172621
Phase 1Taking people
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotrophic Lateral Sclerosis
Where
Baltimore
Age
18 years to 55 years
People
48
Run by
PRG Science & Technology Co., Ltd.
See details and how to joinNCT07221240
Phase 1/2Not yet taking people in United States
Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576)
Where
Rochester
Age
18 years and over
People
1
Run by
n-Lorem Foundation
See details and how to joinNCT07423494
No phaseTaking people
Assessing Perceptual Effects of Interactive Tasks
Where
University Park
Age
18 years to 65 years
People
1,300
Run by
Penn State University
See details and how to joinNCT06828523
No phaseTaking people
Intermuscular Coherence as a Biomarker for ALS
Where
Boston, Irvine, Miami, St Louis
Age
20 years to 90 years
People
650
Run by
University of Chicago
See details and how to joinNCT05104710
No phaseTaking people
Retinal Imaging in Neurodegenerative Disease
Where
Durham
Age
18 years and over
People
2,000
Run by
Duke University
See details and how to joinNCT03233646
No phaseTaking people
UPenn Observational Research Repository on Neurodegenerative Disease
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT04715399