Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Where
Atlanta, Baltimore, Birmingham, Boston, Chapel Hill, Cincinnati, East Providence, Evanston, Houston, New Haven, Rochester, Washington D.C.
Age
12 years to 17 years
People
258 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07227454 · EU 2024-518615-19-00
Phase 1Not yet taking people in United States
Shortened LSD Intervention for Major Depressive Disorder
Where
Baltimore
Age
21 years to 70 years
People
10
Run by
Johns Hopkins University
See details and how to joinNCT07503002
Phase 3Taking people
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Where
Atlanta, Baltimore, Bellevue, Bellflower, Boston, Brooklyn, Bryant, Cary, Chicago, Cincinnati, Clinton, Dallas, Doral, Edmond, Glendale, Hialeah, Houston, Las Vegas, Maitland, Marlton, Miami, Mount Kisco, New York, Oceanside, Oklahoma, Orange, Philadelphia, Riverside, Snellville, Stafford, Tampa, Walnut Creek, Watertown, West Palm Beach
Age
18 years to 74 years
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07573176
Phase 3Taking people
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Where
Bellevue, Cape Coral, Cedarhurst, Columbus, Farmington, Marietta, Miami, New York, Orlando, Redlands, Saint Maries, San Diego, Skokie, Snellville, Watertown
Age
18 years and over
People
348 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07716098
Phase 3Taking people
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Where
Atlantis, Austin, Baltimore, Beaumont, Bellevue, Birmingham, Boston, Bradenton, Chicago, Decatur, DeSoto, Harlingen, Hollywood, Irvine, Katy, Long Beach, Miami, Naples, Oakland, Omaha, Philadelphia, Phoenix, Provo, Sandy Springs, The Bronx, Troy, Valley Village, Watertown, West Chester, West Palm Beach
Age
18 years to 75 years
People
1,000 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07775300 · EU 2025-522310-24-00
No phaseTaking people
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Where
Rochester
Age
22 years to 60 years
People
60
Run by
Mayo Clinic
See details and how to joinNCT07862205
Phase 3Taking people
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Where
Atlanta, Austin, Baltimore, Birmingham, Boston, Chicago, DeSoto, Eden Prairie, Everett, Fort Worth, Gilbert, Glendale, Golden Valley, Houston, Imperial, Jacksonville, Las Vegas, Little Rock, Los Angeles, Maitland, Marietta, Marrero, Naples, New Haven, New Orleans, New York, Oklahoma City, Orange, Philadelphia, Rockville, San Antonio, San Juan Capistrano, Santa Monica, Seattle, Stanford, Tampa, The Bronx, Toms River, Watertown
Age
18 years to 85 years
People
330 worldwide
Run by
Cybin IRL Limited
See details and how to joinNCT06793397 · EU 2024-519270-40-00
Phase 3Taking people
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Atlanta, Avon Lake, Bellaire, Boston, Bryant, Cedarhurst, Chino, Cromwell, Dallas, DeSoto, Draper, Edmond, Farmington, Gaithersburg, Glendale, Hollywood, Houston, Huntsville, Irvine, Little Rock, Los Angeles, Maitland, Miami, Miami Gardens, Mount Kisco, New York, Oceanside, O'Fallon, Oklahoma City, Orange, Orlando, Palm Bay, Philadelphia, Pico Rivera, Richmond, Saint Charles, San Diego, San Francisco, San Jose, Stafford, Tampa, The Bronx, The Woodlands, Upland, Watertown
Age
18 years and over
People
850 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06966401 · EU 2024-519423-24-00
No phaseEnrolling by invitation
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
Where
Stanford
Age
18 years and over
People
12
Run by
Stanford University
See details and how to joinNCT07310381
Phase 2Taking people
Dupilumab in Major Depressive Disorder
Where
New York
Age
18 years to 65 years
People
34
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07908563
Phase 1Taking people
Open-Label Psilocybin Study in Transdiagnostic Population
Where
New Haven
Age
18 years and over
People
50
Run by
Yale University
See details and how to joinNCT06442423
Phase 1/2Taking people
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Where
Belmont
Age
18 years and over
People
100
Run by
Mclean Hospital
See details and how to joinNCT07593222
Phase 2Taking people
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Where
Austin, Buena Park, Chicago, Chino, Dallas, Jacksonville, Las Vegas, Lemon Grove, Maitland, McKinney, Mephis, Methuen, Miami, New Orleans, New York, Norcross, North Charleston, Orange, Orange City, Orlando, Phoenix, Plano, Provo, Rockville, San Diego, Tampa, Walnut Creek
Age
18 years and over
People
360
Run by
Tonix Pharmaceuticals, Inc.
See details and how to joinNCT07621237
Early phase 1Taking people
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
Where
Belmont
Age
18 years and over
People
30
Run by
Mclean Hospital
See details and how to joinNCT07785102
No phaseTaking people
Digital Intervention for Physical Activity
Where
Auburn
Age
19 years to 40 years
People
50
Run by
Auburn University
See details and how to joinNCT07130734
Phase 2Taking people
Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder
Where
Atlanta, Bellaire, Birmingham, Brooklyn, Charlotte, Chino, Clinton, Cromwell, Decatur, Denver, Encino, Everett, Flowood, Garden Grove, Houston, Jacksonville, Las Vegas, Lemon Grove, Marlton, Miami, Montclair, New York, O'Fallon, Oklahoma City, Orange, Orlando, Palm Bay, Phoenix, Portland, Rogers, Saint Charles, Salt Lake City, San Jose, Tampa, Temecula, Warrenville, Wichita Falls
Age
18 years to 70 years
People
230
Run by
Supernus Pharmaceuticals, Inc.
See details and how to joinNCT07226661
No phaseTaking people
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
Where
Costa Mesa
Age
65 years and over
People
20
Run by
BrainHealth Solutions, Inc.
See details and how to joinNCT07876908
Phase 2Taking people
A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder
Where
Jacksonville
Age
18 years to 65 years
People
180
Run by
Alkermes, Inc.
See details and how to joinNCT07901179
No phaseTaking people
Tracking Response to Antidepressants in Advance of Investigational Trials
Where
Watertown
Age
18 years and over
People
400
Run by
Adams Clinical
See details and how to joinNCT04748276
Phase 2Taking people
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
Where
Boston
Age
25 years to 50 years
People
100
Run by
Massachusetts General Hospital
See details and how to joinNCT06136546
No phaseTaking people
Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease
Where
San Francisco
Age
18 years and over
People
10
Run by
University of California, San Francisco
See details and how to joinNCT07896343
No phaseTaking people
Characterization and Treatment of Adolescent Depression
Where
Bethesda, Denver, Los Angeles
Age
11 years to 25 years
People
4,100
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT03388606
Phase 2Taking people
Study of ALTO-300 in MDD
Where
Albuquerque, Allentown, Austin, Bellflower, Blackfoot, Boise, Carlsbad, Chicago, Cincinnati, Clermont, Clinton, Colorado Springs, Conroe, Creve Couer, Dallas, Denver, Evergreen, Fairfax, Fayetteville, Fort Worth, Glendale, Hattiesburg, Hickory, Houston, Jackson, Lafayette, Las Vegas, Los Angeles, Mankato, Marrero, Mather, Media, Miami Gardens, Miami Lakes, Minneapolis, Mission Viejo, Missouri City, Monroe, Moorpark, Moosic, New York, Norwalk, Okeechobee, Oklahoma City, Omaha, Phoenix, Plano, Provo, Richmond, Roanoke, Rochester, Rogers, Rose Hill, San Marcos, Savannah, Snellville, Staten Island, Stephenville, St Louis, Stone Mountain, Tampa, Temecula, West Palm Beach, Wichita, Winston-Salem, Worcester, Yuma
Age
18 years to 70 years
People
325
Run by
Alto Neuroscience
See details and how to joinNCT05922878
Phase 2Taking people
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
Where
Albany, Amherst, Annapolis, Ann Arbor, Austin, Baltimore, Bloomfield Hills, Bryan, Cary, Cedarhurst, Charlotte, Chino, Cincinnati, Dallas, Dayton, Dothan, East Providence, Fairfax, Fort Worth, Galveston, Garfield Heights, Grand Rapids, Houston, Indianapolis, Irving, La Jolla, Lewiston, Los Angeles, Marietta, Naperville, North Myrtle Beach, Oakland, Oceanside, Palo Alto, Phoenix, Pikesville, Plano, Rockville, Sacramento, Saint Augustine, San Diego, San Jose, Savannah, Seattle, Snellville, South Charleston, St Louis, Syracuse, Toms River, Valley Village, Wilton, Worcester
Age
18 years to 75 years
People
178 worldwide
Run by
Alto Neuroscience
See details and how to joinNCT07553637
Phase 2Not yet taking people in United States
Psilocybin for Depression in Veterans
Where
Minneapolis, Salt Lake City, San Diego, San Francisco
Age
18 years to 70 years
People
150
Run by
VA Office of Research and Development
See details and how to joinNCT07895134