Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial
Where
The Bronx
Age
18 years to 70 years
People
30
Run by
Marianne Goodman
See details and how to joinNCT06854224
No phaseTaking people
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
Where
Newark
Age
18 years to 55 years
People
18
Run by
University of Delaware
See details and how to joinNCT06860724
Phase 2Taking people
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
Where
Boston
Age
18 years to 85 years
People
120
Run by
Massachusetts General Hospital
See details and how to joinNCT05570812
No phaseTaking people
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Where
Boston
Age
18 years to 65 years
People
600
Run by
Massachusetts General Hospital
See details and how to joinNCT04296604
Phase 4Enrolling by invitation
Precision Care for Major Depressive Disorder
Where
San Francisco
Age
18 years and over
People
150
Run by
University of California, San Francisco
See details and how to joinNCT06580041
No phaseEnrolling by invitation
Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models
Where
Brookline, Zanesville
Age
13 years to 60 years
People
500
Run by
Psyrin Inc.
See details and how to joinNCT06792175
No phaseTaking people
Mechanisms of Rumination Change in Adolescent Depression
Where
Columbus, Salt Lake City
Age
14 years to 17 years
People
183
Run by
Ohio State University
See details and how to joinNCT03859297
Phase 4Taking people
PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
Where
Stony Brook
Age
18 years to 65 years
People
14
Run by
Stony Brook University
See details and how to joinNCT07095205
No phaseEnrolling by invitation
Intern Health Study 2025
Where
Ann Arbor
Age
18 years and over
People
1,000
Run by
University of Michigan
See details and how to joinNCT07052357
No phaseTaking people
Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits
Where
Portland
Age
18 years and over
People
24
Run by
Portland VA Medical Center
See details and how to joinNCT06728774
No phaseNot yet taking people in United States
Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling
Where
Palo Alto
Age
18 years to 80 years
People
120
Run by
Stanford University
See details and how to joinNCT06748950
No phaseEnrolling by invitation
Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions
Where
New York, Sunnyvale
Age
18 years to 68 years
People
200
Run by
Psyrin Inc.
See details and how to joinNCT06823024
Phase 4Taking people
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Where
Atlanta, Bellflower, Boston, Brandon, Brooklyn, Cherry Hill, Chicago, Cincinnati, Dallas, Doral, Edmond, Everett, Friendswood, Hialeah, Hickory, Jacksonville, Lafayette, Las Vegas, Memphis, Miami, Mount Kisco, New Orleans, New York, Oceanside, Oklahoma City, Orlando, Overland Park, Portland, Redlands, Riverside, Saint Charles, San Antonio, San Diego, Staten Island, Toms River, Upland, Wichita Falls
Age
18 years to 65 years
People
350
Run by
Axsome Therapeutics, Inc.
See details and how to joinNCT06223880
No phaseTaking people
Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
Where
Houston
Age
18 years and over
People
16
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT06695767
No phaseTaking people
RIVER At Home Ketamine Protocols
Where
Bigfork, Helena
Age
18 years and over
People
50,000
Run by
RIVER Foundation
See details and how to joinNCT06070766
No phaseTaking people
InMotion - Telehealth Delivered Exercise Promotion to Treat Major Depression After TBI
Where
Seattle
Age
18 years to 64 years
People
80
Run by
University of Washington
See details and how to joinNCT06005194
No phaseNot yet taking people in United States
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
Where
San Diego
Age
18 years to 80 years
People
170 worldwide
Run by
Neurovalens Ltd.
See details and how to joinNCT06470035
No phaseEnrolling by invitation
Operation of Brain Stimulation Equipment Under Remote Viewing Effectiveness Registry
Where
Encinitas, Plano
Age
12 years and over
People
5,000
Run by
Biomedical Discoveries and Neuroscientific Foundations LLC
See details and how to joinNCT06512324
Phase 2Not yet taking people in United States
Ketamine Treatment for PTSD and MDD in TBI
Where
Minneapolis
Age
18 years to 75 years
People
40
Run by
Minneapolis Veterans Affairs Medical Center
See details and how to joinNCT06228391
No phaseTaking people
Integrated Tele-Behavioral Activation and Fall Prevention for Low-income Homebound Seniors With Depression
Where
Austin
Age
50 years to 100 years
People
320
Run by
University of Texas at Austin
See details and how to joinNCT05011864
No phaseNot yet taking people in United States
Studying Patterns in Patient Engagement Among Treatment Resistant Depression Patients
Where
San Francisco
Age
18 years and over
People
500
Run by
Power Life Sciences Inc.
See details and how to joinNCT06101914
No phaseTaking people
Peripheral Neuroimmune Mechanisms of Hyperthermia
Where
Boston
Age
18 years to 65 years
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT05366270