Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation
Where
Cincinnati
Age
14 years to 18 years
People
60
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT07217444
No phaseTaking people
Optimizing Brain Excitability in Depression
Where
Iowa City, Stanford
Age
18 years to 65 years
People
145
Run by
Stanford University
See details and how to joinNCT07242105
No phaseEnrolling by invitation
Mindfulness-Based Therapy for Serious Mental Illness
Where
Providence
Age
18 years and over
People
160
Run by
Butler Hospital
See details and how to joinNCT06880796
No phaseTaking people
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Where
Boston, New York, Orangeburg
Age
18 years to 65 years
People
120
Run by
NYU Langone Health
See details and how to joinNCT05573074
Early phase 1Enrolling by invitation
Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder
Where
Los Angeles
Age
18 years to 65 years
People
30
Run by
University of California, Los Angeles
See details and how to joinNCT04509102
No phaseTaking people
Impact of Depression on Thermoregulation
Where
University Park
Age
18 years to 40 years
People
64
Run by
Penn State University
See details and how to joinNCT06805851
No phaseEnrolling by invitation
Psychiatric Genotype/Phenotype Project Repository
Where
Nashville
Age
16 years to 65 years
People
2,000
Run by
Vanderbilt University
See details and how to joinNCT00762866
Phase 4Not yet taking people in United States
Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse
Where
Austin
Age
21 years to 70 years
People
50
Run by
University of Texas at Austin
See details and how to joinNCT07369115
Phase 2Taking people
Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
Where
Anaheim, Atlanta, Beachwood, Beaumont, Bellevue, Berlin, Birmingham, Boston, Brandon, Brooklyn, Chandler, Cromwell, Decatur, Elgin, Encino, Fairfax, Glendale, Hialeah, Jacksonville, Lake City, Las Vegas, Long Beach, Los Alamitos, Miami, Miami Gardens, Newport Beach, New York, North Charleston, Oceanside, Oklahoma City, Orange, Orem, Orlando, Peachtree Corners, Phoenix, Rancho Cucamonga, Saint Charles, San Antonio, San Jose, Savannah, Sherman, Staten Island, Tampa, Tucson, Walnut Creek, Watertown, West Covina
Age
18 years to 65 years
People
230
Run by
Autobahn Therapeutics, Inc.
See details and how to joinNCT06633016
No phaseNot yet taking people in United States
Neuronavigated aiTBS for TRD
Where
Dallas, New York, San Diego
Age
18 years to 65 years
People
247
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07329153
No phaseTaking people
The Effect of PROSE or Scleral Lenses on Mental Health
Where
Needham
People
200
Run by
Boston Sight
See details and how to joinNCT07195721
No phaseTaking people
Taking Action for College Students
Where
Philadelphia
Age
18 years and over
People
300
Run by
Temple University
See details and how to joinNCT06700902
Phase 1Enrolling by invitation
Nitrous Oxide- Suicidal Ideation
Where
St Louis
Age
18 years to 65 years
People
50
Run by
Washington University School of Medicine
See details and how to joinNCT03736538
No phaseEnrolling by invitation
Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Where
Bellevue, Columbus, Costa Mesa, La Jolla, Los Angeles, Seattle, Sunnyvale
Age
18 years to 75 years
People
540
Run by
Kernel
See details and how to joinNCT06002100
No phaseTaking people
Neurofeedback to Treat Depression - 2
Where
Philadelphia
Age
18 years to 65 years
People
80
Run by
University of Pennsylvania
See details and how to joinNCT07159061
No phaseTaking people
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
Where
Houston
Age
22 years to 85 years
People
60
Run by
Joao L. DeQuevedo
See details and how to joinNCT04080778
Phase 2Taking people
Psilocybin rTMS for Treatment Resistant Depression
Where
Austin
Age
22 years to 65 years
People
100
Run by
University of Texas at Austin
See details and how to joinNCT06132178
No phaseTaking people
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Where
Pittsburgh, San Francisco
Age
65 years and over
People
120
Run by
University of Southern California
See details and how to joinNCT02434393
No phaseTaking people
Treating Major Depression With Yoga Mono-therapy
Where
San Francisco
Age
18 years and over
People
180
Run by
University of California, San Francisco
See details and how to joinNCT06091527
No phaseTaking people
Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI
Where
San Diego
Age
18 years to 70 years
People
76
Run by
University of California, San Diego
See details and how to joinNCT05377177
Phase 4Taking people
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
Where
Chapel Hill
Age
18 years to 45 years
People
75
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT06610305
Phase 3Taking people
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Avon Lake, Boston, Dallas, Everett, Garden Grove, Hollywood, Houston, Little Rock, Maitland, Mount Kisco, Orange, Pico Rivera, Richmond, San Diego, The Woodlands, Upland, Watertown, Westlake
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06786624 · EU 2024-519418-29-00
No phaseTaking people
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Where
Houston
Age
22 years to 70 years
People
84
Run by
Baylor College of Medicine
See details and how to joinNCT05418894
No phaseTaking people
Stress Dynamics and Familial Risk for Depression in Female Adolescents
Where
Belmont
Age
13 years to 15 years
People
148
Run by
Mclean Hospital
See details and how to joinNCT06816329
No phaseTaking people
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
Where
Belmont
Age
18 years to 45 years
People
228
Run by
Mclean Hospital
See details and how to joinNCT05630963