Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 4Not yet taking people in United States
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Where
Chapel Hill
Age
12 years to 16 years
People
50
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT07544966
Phase 2Not yet taking people in United States
Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder
Where
Dallas, Richardson
Age
21 years to 55 years
People
100
Run by
Sherwood Brown, MD, PhD
See details and how to joinNCT07734701
No phaseTaking people
Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
Where
Stanford
Age
65 years and over
People
30
Run by
Stanford University
See details and how to joinNCT07188623
No phaseTaking people
Positive Processes and Transition to Health (PATH)
Where
Cleveland, Newark, Seattle
Age
18 years to 65 years
People
135
Run by
Case Western Reserve University
See details and how to joinNCT06093906
No phaseTaking people
Accelerated Intermittent Theta Burst in Treatment-Naive Adolescents
Where
Austin
Age
13 years to 20 years
People
40
Run by
University of Texas at Austin
See details and how to joinNCT06523439
No phaseTaking people
Enhancing Veteran-Clinical Collaboration in VA PRRCs
Where
Albuquerque, San Diego, West Los Angeles
Age
18 years and over
People
119
Run by
VA Office of Research and Development
See details and how to joinNCT06898879
Phase 1Taking people
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Where
Bethesda
Age
18 years to 70 years
People
64
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT04582916
No phaseTaking people
Home-Based tDCS Treatment Of Major Depressive Disorder
Where
Boston
Age
22 years to 70 years
People
200
Run by
Sooma Medical Inc
See details and how to joinNCT06976697
Phase 3Taking people
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
Where
Charlestown
Age
18 years to 55 years
People
20
Run by
Sharmin Ghaznavi
See details and how to joinNCT06247839
No phaseTaking people
taVNS or TMS or Both for Depression
Where
Charleston
Age
18 years to 75 years
People
24
Run by
Medical University of South Carolina
See details and how to joinNCT05725239
No phaseTaking people
Pain and Major Depressive Disorder
Where
Los Angeles
Age
18 years to 75 years
People
54
Run by
University of California, Los Angeles
See details and how to joinNCT04556890
Phase 3Taking people
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Atlanta, Boston, Bryant, Charlottesville, DeSoto, Glendale, Hollywood, Huntsville, Irvine, Mason, Miami, New York, Redlands, Saint Charles, San Francisco, Tampa, The Bronx
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06911112 · EU 2024-519420-25-00
No phaseTaking people
Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression
Where
Hanover, Lebanon
Age
18 years and over
People
320
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT07174557
Phase 2Taking people
Apimostinel + Automated Neurocognitive Training for Depression
Where
Pittsburgh
Age
18 years to 60 years
People
150
Run by
Rebecca Price
See details and how to joinNCT06400121
Phase 3Taking people
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Aurora, Cedarhurst, Charlotte, Chino, Cromwell, Farmington, Gaithersburg, Los Angeles, Maitland, Miami, New York, Philadelphia, Stanford, Tampa
Age
18 years and over
People
200 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT06963021 · EU 2024-519421-37-00
Phase 1/2Taking people
Psilocybin to Treat Depression in Spinal Cord Injury
Where
The Bronx
Age
22 years and over
People
30
Run by
James J. Peters Veterans Affairs Medical Center
See details and how to joinNCT07251491
No phaseTaking people
Maternal Mindfulness: Depression and Postpartum Pain
Where
Champaign
Age
18 years to 45 years
People
75
Run by
University of Illinois at Urbana-Champaign
See details and how to joinNCT05400382
No phaseTaking people
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
Where
Charleston, Durham
Age
21 years and over
People
96
Run by
Medical University of South Carolina
See details and how to joinNCT07050355
No phaseTaking people
Closed-Loop Deep Brain Stimulation for Major Depression
Where
San Francisco
Age
22 years to 70 years
People
12
Run by
Andrew Krystal
See details and how to joinNCT04004169
Phase 2Taking people
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Where
Allentown, Austin, Bellevue, Birmingham, Boston, Cedarhurst, Colorado Springs, Denver, DeSoto, Elgin, Encino, Farmington, Houston, Huntsville, Independence, Irvine, Jacksonville, Las Vegas, Los Angeles, Louisville, Margate, Memphis, Miami, Oklahoma City, Orem, Orlando, Russells Mills, San Antonio, Savannah, Upland, Walnut Creek, Wichita, Wichita Falls
Age
18 years to 64 years
People
164
Run by
Syndeio Biosciences, Inc
See details and how to joinNCT06547489
Phase 1/2Taking people
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
Where
Mason
Age
18 years to 60 years
People
67
Run by
University of Cincinnati
See details and how to joinNCT06795451
Phase 4Not yet taking people in United States
Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
Where
New York
Age
18 years to 59 years
People
12
Run by
New York State Psychiatric Institute
See details and how to joinNCT07139106
No phaseTaking people
Mindful Self-Compassion for Anxiety Disorders and Depression
Where
Washington D.C.
Age
18 years to 75 years
People
40
Run by
Georgetown University
See details and how to joinNCT05671419
Phase 2Taking people
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Where
Allentown, Atascocita, Cedarhurst, Chicago, DeSoto, Franklin, Independence, Jacksonville, Metairie, Miami, Montclair, Moosic, Naples, New York, Oceanside, Philadelphia, Phoenix, Raleigh, Redlands, Riverview, Rochester Hills, Rockville, San Francisco, San Jose, Stone Mountain, Towson, Tucson, Walnut Creek, West Palm Beach, Worcester
Age
18 years to 64 years
People
164
Run by
Syndeio Biosciences, Inc
See details and how to joinNCT07115329
Phase 2Taking people
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
Where
Atlanta, Bellevue, Bellflower, Bentonville, Canton, Chicago, Culver City, Decatur, DeSoto, Detroit, Doral, Garden Grove, Hollywood, Las Vegas, Lemon Grove, Little Rock, Los Angeles, Miami Lakes, New York, Orange, Philadelphia, Richardson, Riverside, St Louis, Torrance, West Palm Beach
Age
18 years to 65 years
People
320
Run by
LB Pharmaceuticals Inc.
See details and how to joinNCT07494305