Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Accelerated TMS for Perinatal Depression
Where
Boston
Age
18 years to 55 years
People
24
Run by
Brigham and Women's Hospital
See details and how to joinNCT06968390
Phase 4Taking people
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Where
Augusta, Austin, Bonita Springs, Bryant, Chino, Fresno, Hialeah, Independence, Long Beach, Miami, Naperville, Omaha, Orange, Orange City, Port Charlotte, Redlands, Richmond, San Diego, Tampa
Age
18 years and over
People
100
Run by
Neurocrine Biosciences
See details and how to joinNCT07105111
Phase 4Not yet taking people in United States
Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional Blunting
Where
State College
Age
18 years to 75 years
People
30
Run by
Future Options Research, LLC
See details and how to joinNCT07824206
Phase 3Taking people
Lumateperone for Late-Life Depression
Where
St Louis, Tucson
Age
60 years and over
People
100
Run by
Eric Lenze
See details and how to joinNCT07623135
Phase 1Taking people
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Where
Houston
Age
21 years to 45 years
People
100
Run by
Texas A&M University
See details and how to joinNCT06480201
Phase 1Taking people
Pattern Separation in Major Depressive Disorder
Where
New York
Age
18 years to 50 years
People
30
Run by
Jeffrey Miller
See details and how to joinNCT07139834
No phaseTaking people
Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Where
San Diego
Age
18 years to 85 years
People
10
Run by
University of California, San Diego
See details and how to joinNCT07217223
Phase 1Taking people
DBS for Depression
Where
Queens
Age
18 years to 65 years
People
20
Run by
Northwell Health
See details and how to joinNCT06096207
No phaseTaking people
An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.
Where
Pittsburgh
Age
18 years and over
People
220
Run by
University of Pittsburgh
See details and how to joinNCT07373470
No phaseTaking people
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
Where
San Francisco
Age
18 years and over
People
90
Run by
University of California, San Francisco
See details and how to joinNCT04061148
Phase 2Taking people
Leucine in Midlife Depression
Where
Atlanta
Age
35 years to 65 years
People
75
Run by
Emory University
See details and how to joinNCT06580145
No phaseTaking people
One-Day cTBS Over the Precuneus
Where
Belmont
Age
18 years and over
People
69
Run by
Mclean Hospital
See details and how to joinNCT07758010
No phaseTaking people
Evaluating Conversational Artificial Intelligence for Depression Management
Where
Fairfax
Age
18 years to 85 years
People
130
Run by
George Mason University
See details and how to joinNCT07105397
No phaseNot yet taking people in United States
REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness
Where
Greenwich, New Haven
Age
22 years and over
People
50
Run by
Yale University
See details and how to joinNCT07792252
Early phase 1Not yet taking people in United States
Individualized fMRI-guided TMS for Depression
Where
Philadelphia
Age
18 years to 65 years
People
60
Run by
University of Pennsylvania
See details and how to joinNCT07804459
No phaseEnrolling by invitation
Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress
Where
Evanston
Age
18 years and over
People
8
Run by
Endeavor Health
See details and how to joinNCT07810023
No phaseNot yet taking people in United States
Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD)
Where
Washington
Age
13 years to 17 years
People
10
Run by
Edward Via Virginia College of Osteopathic Medicine
See details and how to joinNCT07807735
No phaseNot yet taking people in United States
Optimizing Stimulation Parameters for Electroconvulsive Therapy
Where
Philadelphia
People
64
Run by
University of Pennsylvania
See details and how to joinNCT07561307
Phase 2Not yet taking people in United States
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
Where
Atlanta, Boston, Cedarhurst, Cincinnati, Columbus, Dallas, Everett, Gaithersburg, Garden Grove, Glendale, Jacksonville, Lemon Grove, Little Rock, Mount Kisco, Oakland, Oklahoma City, Orlando, Phoenix, Rogers, Staten Island, Upland
Age
18 years to 65 years
People
200 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07772531
No phaseTaking people
Decoding and Modulating Affective Brain States
Where
Philadelphia
Age
18 years to 65 years
People
40
Run by
University of Pennsylvania
See details and how to joinNCT05437705
No phaseTaking people
The OBSERVE Protocol
Where
Ann Arbor, Atlanta, Bellaire, Milford, Moore, Nashville, New Haven, Seattle
People
450
Run by
Yale University
See details and how to joinNCT06725277
No phaseNot yet taking people in United States
Neural Correlates of Suicidal Behavior in Youth
Where
Cleveland
Age
14 years to 24 years
People
60
Run by
The Cleveland Clinic
See details and how to joinNCT07568054
No phaseTaking people
PCS in Severe Treatment Resistant Depression
Where
Minneapolis
Age
22 years to 70 years
People
15
Run by
University of Minnesota
See details and how to joinNCT04124341
No phaseTaking people
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Where
Tallahassee
Age
18 years to 65 years
People
72
Run by
Florida State University
See details and how to joinNCT06132581
Phase 2Taking people
5-HTP and Creatine for Depression R33 Phase
Where
Salt Lake City
Age
18 years to 65 years
People
106
Run by
University of Utah
See details and how to joinNCT05895747