Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Cognitive Strategies in Early Psychosis 2
Where
Minneapolis
Age
18 years to 35 years
People
24
Run by
University of Minnesota
See details and how to joinNCT07263022
No phaseTaking people
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression
Where
Boston
Age
18 years and over
People
20
Run by
Massachusetts General Hospital
See details and how to joinNCT07563868
No phaseTaking people
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
Where
Charleston
Age
18 years to 65 years
People
120
Run by
Medical University of South Carolina
See details and how to joinNCT05977439
No phaseTaking people
Transition Care for FEP
Where
Chicago, Harvey
Age
18 years to 40 years
People
75
Run by
University of Chicago
See details and how to joinNCT07713849
Phase 2Taking people
Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness
Where
Boston, Sunnyvale
Age
18 years to 65 years
People
180
Run by
Brigham and Women's Hospital
See details and how to joinNCT06376734
No phaseTaking people
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Where
Dallas
Age
21 years to 70 years
People
12
Run by
Nader Pouratian
See details and how to joinNCT03952962
No phaseTaking people
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
Where
Birmingham, Huntsville
Age
10 years to 24 years
People
240
Run by
University of Alabama at Birmingham
See details and how to joinNCT05437588
No phaseEnrolling by invitation
Intern Health Study 2026
Where
Ann Arbor
Age
18 years and over
People
1,000
Run by
University of Michigan
See details and how to joinNCT07685925
No phaseTaking people
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Where
Boston
Age
18 years to 65 years
People
120
Run by
Massachusetts General Hospital
See details and how to joinNCT07082998
No phaseNot yet taking people in United States
Debriefing Consult for Psychiatric Symptoms After Severe Maternal Morbidity
Where
Los Angeles
Age
18 years and over
People
52
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT07684521
Phase 1/2Not yet taking people in United States
Pregnenolone for Cannabis Use Disorder and Depression
Where
Dallas, Richardson
Age
18 years to 50 years
People
20
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07685964
No phaseTaking people
Enhancing Slow Wave Sleep in Depression
Where
Winston-Salem
Age
40 years to 80 years
People
12
Run by
Wake Forest University Health Sciences
See details and how to joinNCT07143838
No phaseTaking people
CARED : A Novel Rapid Treatment Paradigm for Depression
Where
Chapel Hill
Age
18 years to 70 years
People
30
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT07507370
No phaseTaking people
Sleep TMS for Depression
Where
Stanford
Age
18 years to 65 years
People
55
Run by
Stanford University
See details and how to joinNCT06824415
Phase 1Enrolling by invitation
Induction of Dreaming With EEG and Anesthesia in Healthy Adults
Where
Stanford
Age
18 years to 70 years
People
15
Run by
Stanford University
See details and how to joinNCT07198711
Phase 4Taking people
RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)
Where
Rochester
Age
18 years to 65 years
People
120
Run by
Mayo Clinic
See details and how to joinNCT07266545
Phase 1Taking people
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
Where
West Haven
Age
21 years to 65 years
People
60
Run by
Deepak C. D'Souza
See details and how to joinNCT06671977
No phaseNot yet taking people in United States
Sham-Controlled Rapid-Acting Neuromodulation for Depression
Where
Sacramento
Age
18 years to 65 years
People
264
Run by
University of California, Davis
See details and how to joinNCT07487454
Phase 2Taking people
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Where
Anaheim, Atlanta, Austin, Avon Lake, Bellaire, Bellevue, Chicago, Columbus, Dothan, Everett, Hollywood, Imperial, Jacksonville, Las Vegas, Lemon Grove, Little Rock, Long Beach, Memphis, Miami, New York, Norcross, Oklahoma City, Orlando, Phoenix, Richardson, Riverview, Sherman Oaks, Temecula, Walnut Creek, Warrenville
Age
18 years to 65 years
People
195
Run by
AbbVie
See details and how to joinNCT07276997
No phaseTaking people
Evaluating tDCS Brain-stimulation in Depression Using MRI
Where
Los Angeles
Age
20 years to 55 years
People
144
Run by
University of California, Los Angeles
See details and how to joinNCT05598034
No phaseTaking people
tDCS: Sleep to Mood in Depression (S2M-D)
Where
New York
Age
18 years to 65 years
People
35
Run by
NYU Langone Health
See details and how to joinNCT07572526
No phaseTaking people
Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis
Where
Chicago
Age
18 years to 64 years
People
146
Run by
University of Illinois Chicago
See details and how to joinNCT05051618
Phase 4Taking people
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
Where
Syracuse
Age
16 years to 70 years
People
2,500 worldwide
Run by
Parnassia Groep
See details and how to joinNCT05656469 · EU 2023-509680-25-00
No phaseTaking people
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Where
Boston
Age
18 years and over
People
80
Run by
Massachusetts General Hospital
See details and how to joinNCT06878859
Early phase 1Taking people
Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
Where
Atlanta
Age
18 years to 65 years
People
140
Run by
Emory University
See details and how to joinNCT05327699