Sickle cell disease trials in United States

In United States 133 Also abroad 204

133 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease
Where
Philadelphia
Age
18 years and over
People
50
Run by
University of Pennsylvania
See details and how to joinNCT07316478
No phaseTaking people
Writing Relaxing Beats in Adolescents Who Have Sickle Cell Disease
Where
Rochester
Age
11 years to 18 years
People
30
Run by
Mayo Clinic
See details and how to joinNCT07222475
Phase 1Taking people
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
Where
Boston
Age
13 years to 40 years
People
10
Run by
Daniel Bauer
See details and how to joinNCT06647979
No phaseTaking people
MULTIsite Feasibility of MUSIc Therapy to Address Quality Of Life in Sickle Cell Disease
Where
Cleveland, Greenville
Age
14 years and over
People
90
Run by
University of California, Irvine
See details and how to joinNCT06853158
No phaseTaking people
A Long-term Follow-up Study in Patients Who Received BEAM-101
Where
Atlanta, Birmingham, Boston, Charleston, Cleveland, Detroit, Hackensack, Jacksonville, Memphis, Milwaukee, Minneapolis, Nashville, New York, Philadelphia, Phoenix, St Louis
Age
14 years to 37 years
People
50
Run by
Beam Therapeutics Inc.
See details and how to joinNCT07373639
No phaseTaking people
Verifying Antibodies After Live Immunization Delivery (VALID): A Study of Measles Vaccine Immunogenicity in Children With Sickle Cell Disease
Where
Cincinnati
Age
6 months to 6 years
People
130 worldwide
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT07356050
No phaseTaking people
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
Where
Pittsburgh
Age
2 months to 60 years
People
50
Run by
Paul Szabolcs
See details and how to joinNCT04528355
Phase 1Taking people
Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
Where
Augusta
Age
18 years and over
People
18
Run by
Abdullah Kutlar
See details and how to joinNCT01245179
No phaseTaking people
Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises
Where
Baltimore
Age
18 years and over
People
30
Run by
University of Maryland, Baltimore
See details and how to joinNCT06184126
Phase 2Taking people
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
Where
Pittsburgh
Age
2 months to 55 years
People
100
Run by
Paul Szabolcs
See details and how to joinNCT01962415
No phaseTaking people
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease
Where
Boston
Age
8 years to 18 years
People
8
Run by
Boston Children's Hospital
See details and how to joinNCT04166526
No phaseTaking people
SMYLS Multi-site Trial
Where
Charleston
Age
14 years to 21 years
People
272
Run by
Medical University of South Carolina
See details and how to joinNCT06035939
No phaseTaking people
Integrative Training Program for Pediatric Sickle Cell Pain
Where
Atlanta, Cincinnati, Hartford
Age
12 years to 18 years
People
155
Run by
Emory University
See details and how to joinNCT06691867
No phaseTaking people
Cutaneous Hydration Assessment in SCD
Where
Pittsburgh
Age
12 years and over
People
30
Run by
Enrico Novelli
See details and how to joinNCT05210114
Phase 2Taking people
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
Where
New York
Age
18 years and over
People
60
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT05519111
Phase 2Taking people
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody
Where
Washington D.C.
Age
2 years to 25 years
People
12
Run by
Children's National Research Institute
See details and how to joinNCT06358638
Phase 4Taking people
Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)
Where
Cincinnati
Age
6 months and over
People
50
Run by
Children's Hospital Medical Center, Cincinnati
See details and how to joinNCT07177300
No phaseTaking people
Cerebral Oxygen Metabolism in Children
Where
St Louis
Age
3 years to 50 years
People
350
Run by
Washington University School of Medicine
See details and how to joinNCT04157179
Phase 1/2Enrolling by invitation
The BENeFiTS Trial in Beta Thalassemia Intermedia
Where
Boston, New York, Oakland, Weston
Age
18 years and over
People
36 worldwide
Run by
Phoenicia BioScience
See details and how to joinNCT04432623
No phaseTaking people
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
Where
Farmington
Age
50 years and over
People
50
Run by
UConn Health
See details and how to joinNCT07083531
Phase 1/2Taking people
Cannabidiol in Sickle Cell Disease
Where
Manhattan
Age
18 years and over
People
52
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT06930703
No phaseTaking people
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
Where
Augusta, Birmingham, Chicago, Cleveland, Houston, Memphis, Oakland, Philadelphia, Phoenix
Age
18 years and over
People
500
Run by
RTI International
See details and how to joinNCT06385886
Phase 3Not yet taking people in United States
A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis
Where
Atlanta, Baltimore, Coral Gables, Detroit, Greenville, Washington D.C.
Age
6 years to 21 years
People
120
Run by
Asklepion Pharmaceuticals, LLC
See details and how to joinNCT06989567
No phaseEnrolling by invitation
A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301
Where
Atlanta, Aurora, Charleston, Charlotte, Cleveland, Columbus, Dallas, Fort Worth, Minneapolis, Nashville, New Haven, New York, Oakland, Philadelphia, St. Petersburg
Age
12 years to 50 years
People
54 worldwide
Run by
Editas Medicine, Inc.
See details and how to joinNCT06363760
Phase 3Enrolling by invitation
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
Where
Atlanta, Bethesda, Birmingham, Chapel Hill, Charleston, Chicago, Durham, Hackensack, Houston, Minneapolis, New Hyde Park, New York, Oakland, Philadelphia, Richmond
Age
2 years to 53 years
People
85 worldwide
Run by
Genetix Biotherapeutics Inc.
See details and how to joinNCT04628585 · EU 2024-513901-30-00