Depression: trials for referral
746 open trials in the registries we read. Each row links to its registry record.
Registry data only. Frontlight does not judge whether a patient can take part: the trial team decides.
Where the open trials are
Type a city to sort by distance. The distance is worked out in your browser; the city is not sent anywhere.
400 trials shown · Showing the 400 most recently updated of 746 open trials.
No phase1 site
RecruitingUnited States
NCT07862205
EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression
Mayo Clinic
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited Kingdom
NCT07694076
Mechanisms of Repeated Real-time Biofeedback With 7-Tesla MRI in Depression
University of Oxford
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT06462196
Natural History of Depression, Bipolar Disorder and Suicide Risk
National Institute of Mental Health (NIMH)
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 349 sites
RecruitingBrazil, Spain, Hungary, Italy, Romania, Taiwan
NCT07227454
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
Janssen Research & Development, LLC
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 22 sites
RecruitingUnited States
NCT00018057
Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
National Institute of Mental Health (NIMH)
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingUnited States
NCT05538910
Defining Neurobiological Links Between Substance Use and Mental Illness
National Institute on Drug Abuse (NIDA)
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 353 sites
RecruitingArgentina, Brazil, Canada, China, Malaysia, Taiwan
NCT07573176
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
Janssen Research & Development, LLC
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 339 sites
RecruitingChina, Japan, Taiwan, United States
NCT07716098
A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 3170 sites
RecruitingAustralia, Brazil, Canada, China, Germany, Spain
NCT07775300
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
Eli Lilly and Company
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govNo phase7 sites
RecruitingFrance
NCT06507787
Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects
Alcediag
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 3197 sites
RecruitingArgentina, Bulgaria, Brazil, Colombia, Czechia, Spain
NCT06559306
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Janssen Research & Development, LLC
Registry updated 3 Nov 2026 · The registries disagree on the status
Registry record: ClinicalTrials.govNo phase1 site
RecruitingIndia
NCT07893002
A Randomized, 52-Week Extension Study to Evaluate the Maintenance of Remission, Relapse Prevention, and Long-Term Safety of CreNeuroS™ in Patients With Major Depressive Disorder Who Achieved Remission Following an 8-Week Parent Study
Sichuan Credit Pharmaceutical Co., Ltd.
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 11 site
Not yet recruitingUnited States
NCT07503002
Shortened LSD Intervention for Major Depressive Disorder
Johns Hopkins University
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 30 sites
Not yet recruiting
NCT07747389
A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder
Intra-Cellular Therapies, Inc.
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 369 sites
RecruitingBulgaria, Spain, France, India, Lithuania, Serbia
NCT05850689
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
Intra-Cellular Therapies, Inc.
Registry updated 3 Nov 2026
Registry record: ClinicalTrials.govPhase 378 sites
RecruitingAustralia, Czechia, Germany, United Kingdom, Greece, Ireland
NCT06793397
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase0 sites
Not yet recruiting
NCT07910318
Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders
Assiut University
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 21 site
RecruitingUnited States
NCT07908563
Dupilumab in Major Depressive Disorder
Icahn School of Medicine at Mount Sinai
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
By invitation onlyGhana
NCT07064928
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
University of California, San Francisco
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingHong Kong SAR China
NCT07908628
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
New Life Psychiatric Rehabilitation Association
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase1 site
By invitation onlyUnited States
NCT07310381
Vagus Nerve Stimulation (VNS) Electroencephalogram (EEG) Protocol Supplement
Stanford University
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govNo phase4 sites
RecruitingUnited States
NCT07594483
Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Motif Neurotech, Inc.
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 3137 sites
RecruitingAustralia, Belgium, Bulgaria, Canada, Czechia, Estonia
NCT06966401
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Neurocrine Biosciences
Registry updated 2 Nov 2026
Registry record: ClinicalTrials.govPhase 1/21 site
RecruitingUnited States
NCT07593222
Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder
Mclean Hospital
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
Not yet recruitingCanada
NCT07906496
Acceptance and Committment Therapy Combined With Ketamine in Difficult-to-Treat Depression.
University of British Columbia
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govNo phase1 site
RecruitingFrance
NCT06234176
Impact of Psychomotor Therapy on the Quality of Life in Depression
Centre Hospitalier Esquirol
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 11 site
RecruitingUnited States
NCT03973268
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 21 site
Not yet recruitingDenmark
2026-526685-25-00
RECAP-D
Region Hovedstaden
Registry updated 30 Oct 2026
Registry record: EU CTISPhase 20 sites
Not yet recruiting
NCT07745569
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
University of New Mexico
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.govPhase 227 sites
RecruitingUnited States
NCT07621237
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
Tonix Pharmaceuticals, Inc.
Registry updated 30 Oct 2026
Registry record: ClinicalTrials.gov
The same sites as a list
- United States182 open trials
- Canada37 open trials
- China31 open trials
- Germany19 open trials
- Spain17 open trials
- United Kingdom16 open trials
- France14 open trials
- Poland13 open trials
- Czechia11 open trials
- Bulgaria11 open trials
- Netherlands11 open trials
- Taiwan10 open trials
- Italy9 open trials
- Brazil8 open trials
- Romania8 open trials
- Australia8 open trials
- Denmark8 open trials
- Hungary6 open trials
- South Korea6 open trials
- Serbia6 open trials
- Sweden6 open trials
- Slovakia5 open trials
- Japan4 open trials
- Mexico4 open trials
- Greece4 open trials
- India4 open trials
- Hong Kong SAR China4 open trials
- Belgium4 open trials
- Finland4 open trials
- Switzerland4 open trials
- Norway4 open trials
- Portugal3 open trials
- Lithuania3 open trials
- Pakistan3 open trials
- Argentina2 open trials
- Puerto Rico2 open trials
- Ireland2 open trials
- Estonia2 open trials
- Latvia2 open trials
- Chile2 open trials
- Vietnam2 open trials
- Indonesia2 open trials
- Austria2 open trials
- Malaysia1 open trials
- Colombia1 open trials
- Ghana1 open trials
- Croatia1 open trials
- Bahrain1 open trials
- Ethiopia1 open trials
- Singapore1 open trials
- Slovenia1 open trials
- Egypt1 open trials
- Kazakhstan1 open trials
- Malawi1 open trials
- Saudi Arabia1 open trials
- Bangladesh1 open trials
- Israel1 open trials
Who treats this
Institutions with trials or publications in this disease (OpenAlex, registries). Institutions only, no people.
Amsterdam UMC Location Vrije Universiteit Amsterdam
Amsterdam, Netherlands
1 trials · 63 publications · ROR
Centro de Investigación Biomédica en Red de Salud Mental
Madrid, Spain
0 trials · 125 publications · ROR
Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
0 trials · 120 publications · ROR
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Barcelona, Spain
0 trials · 57 publications · ROR
Donders Institute for Brain, Cognition and Behaviour
Nijmegen, Netherlands
0 trials · 71 publications · ROR
Florey Institute of Neuroscience and Mental Health
Melbourne, Australia
0 trials · 63 publications · ROR
South London and Maudsley NHS Foundation Trust
London, United Kingdom
1 trials · 90 publications · ROR
The Affiliated Yongchuan Hospital of Chongqing Medical University
Chongqing, China
0 trials · 113 publications · ROR
The University of Texas Health Science Center at Houston
Houston, United States
3 trials · 72 publications · ROR
The University of Texas Southwestern Medical Center
Dallas, United States
0 trials · 120 publications · ROR
University of California, San Francisco
San Francisco, United States
5 trials · 103 publications · ROR
University of Electronic Science and Technology of China
Chengdu, China
0 trials · 128 publications · ROR
University of North Carolina at Chapel Hill
Chapel Hill, United States
3 trials · 77 publications · ROR
What changed in the last 7 days
Registry facts, one per line, newest first.
Phase changed: No phase → Phase 4
NCT05656469 · Phase 4 · Germany, Spain, United Kingdom, Netherlands, Romania, Serbia
Source: ClinicalTrials.gov
Results card
Trials that finished or stopped in the last 3 years, with the reason the registry gives and linked publications.
Phase 3Ended 23 Oct 2026
Completed223 participants
NCT06564818
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
Phase 2Ended 16 Oct 2026
Phase 1Ended 26 Sept 2026
Completed232 participants
NCT07452692
A Study to Assess the Skin Irritation and Sensitization of Selegiline TDS in Healthy Subjects
Phase 1/2Ended 11 Sept 2026
No phaseEnded 31 Aug 2026
Completed41 participants
NCT07088939
Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course
Phase 3Ended 20 Aug 2026
Completed786 participants
NCT06827431
The Research of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With Depression
Phase 2Ended 10 Aug 2026
Completed105 participants
NCT06785012
A Study to Explore the Efficacy of JNJ-89495120 in the Treatment of Major Depressive Disorder
Phase 3Ended 10 Aug 2026
Completed495 participants
NCT06029439
Long-term Study to Assess the Safety and Effectiveness of NMRA-335140 in Participants with Major Depressive Disorder
No phaseEnded 31 Jul 2026
Completed45 participants
NCT06050070
Targeting Large-scale Networks in Depression With Real-time Functional Magnetic Resonance Imaging (fMRI) Neurofeedback
Phase 2Ended 27 Jul 2026
Completed126 participants
NCT06236880
A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
Phase 4Ended 13 Jul 2026
Completed47 participants
NCT07053345
A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression
Phase 2Ended 8 Jul 2026
Completed497 participants
NCT06254612
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder
No phaseEnded 8 Jul 2026
Phase 2/3Ended 30 Jun 2026
Completed100 participants
NCT05054699
Electro-Magnetic Convulsive Therapies for Depression: a Non-inferiority Study
No phaseEnded 30 Jun 2026
Completed58 participants
NCT04502758
Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation
No phaseEnded 30 Jun 2026
Completed9 participants
NCT07274917
Stereotactic Radiotherapy Treatment for Treatment-Resistant Depression
No phaseEnded 30 Jun 2026
Completed120 participants
NCT05257902
Clinical Effectiveness of Choline Alphoscerate for Older Adults With Major Depression and Subjective Memory Complaints
No phaseEnded 30 Jun 2026
Phase 3Ended 19 Jun 2026
Completed140 participants
NCT05415397
Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
No phaseEnded 18 Jun 2026
Completed56 participants
NCT07369180
NQ Square TMS for Major Depressive Disorder: One Day, Three Sessions in Adults
Phase 3Ended 17 Jun 2026
Completed430 participants
NCT06058013
Study to Assess the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder
No phaseEnded 15 Jun 2026
Phase 3Ended 11 Jun 2026
Completed422 participants
NCT06058039
Study to Assess the Effects of Oral NMRA-335140 in Participants With Major Depressive Disorder
No phaseEnded 11 Jun 2026
Phase 2Ended 6 Jun 2026
Completed20 participants
NCT05757791
Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD)
Early Phase 1Ended 6 Jun 2026
No phaseEnded 4 Jun 2026
Early Phase 1Ended 1 Jun 2026
Phase 2Ended 1 Jun 2026
No phaseEnded 1 Jun 2026
No phaseEnded 30 May 2026
Completed50 participants
NCT05435820
Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder: A Study of Dosing With Laser
No phaseEnded 30 May 2026
Completed20 participants
NCT06670040
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
No phaseEnded 29 May 2026
Completed176 participants
NCT04675593
Using mHealth to Improve Adherence and Reduce Blood Pressure in Individuals With Hypertension and Mood Disorders
No phaseEnded 22 May 2026
Completed40 participants
NCT06874374
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
Phase 1Ended 18 May 2026
Completed26 participants
NCT06570369
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
No phaseEnded 18 May 2026
Phase 4Ended 16 May 2026
No phaseEnded 12 May 2026
Completed24 participants
NCT05239780
Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients
Phase 2Ended 8 May 2026
No phaseEnded 1 May 2026
Completed120 participants
NCT06981000
A Feasibility Study of Nature-based Health Interventions for People With Mild to Moderate Anxiety, Depression and Stress
No phaseEnded 28 Apr 2026
Phase 1Ended 28 Apr 2026
Completed15 participants
NCT06920238
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
Phase 3Ended 15 Apr 2026
Completed258 participants
NCT05624268
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Phase 2Ended 14 Apr 2026
Phase 1Ended 9 Apr 2026
Phase 2Ended 9 Apr 2026
Phase 1/2Ended 1 Apr 2026
No phaseEnded 31 Mar 2026
Completed13 participants
NCT01590862
ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators
Phase 4Ended 31 Mar 2026
Completed120 participants
NCT04276259
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
Phase 2Ended 18 Mar 2026
Completed233 participants
NCT06423781
Long-term Safety Study of BHV-7000 in Participants With Major Depressive Disorder (MDD)
Phase 3Ended 11 Mar 2026
No phaseEnded 5 Mar 2026
Completed104 participants
NCT06357832
New Investigational Stimulation Protocol for Treatment of Major Depression Disorder (MDD)
No phaseEnded 2 Mar 2026
Completed12 participants
NCT05486676
VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression
No phaseEnded 1 Mar 2026
Phase 4Ended 28 Feb 2026
No phaseEnded 27 Feb 2026
No phaseEnded 26 Feb 2026
Completed2 participants
NCT06655623
A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case
Phase 2Ended 23 Feb 2026
Completed214 participants
NCT06836063
Study to Evaluate Efficacy and Safety of Ropanicant in MDD Patients
Phase 4Ended 23 Feb 2026
Phase 2Ended 9 Feb 2026
Completed126 participants
NCT07101120
A Phase 2 Study to Evaluate Efficacy and Safety of KH607 Tablets in Adult Participents With Major Depressive Disorder
Not medical advice. fetched 4 Nov 2026