St. Michael's Hospital

The trials here

What the 98 trials at this site are about, from their registry records.

Conditions

• Depression11 trials
• Coronary artery disease9 trials
• Heart failure9 trials
• Atrial fibrillation8 trials
• Stroke7 trials
• Alzheimer disease6 trials
• Chronic kidney disease6 trials
• Multiple sclerosis6 trials
• Haemophilia5 trials
• Aortic stenosis4 trials
• High blood pressure4 trials
• Osteoarthritis3 trials
• and 22 more

Phase

• Phase 329 trials
• Phase 210 trials
• Phase 48 trials
• Phase 11 trial
• Phase 1/21 trial
• Phase 2/31 trial

Status

• Active, not recruiting29 trials
• Completed27 trials
• Recruiting24 trials
• Not yet recruiting9 trials
• Enrolling by invitation3 trials
• Terminated3 trials
• Withdrawn2 trials
• Suspended1 trial

Lead sponsor

• Unity Health Toronto11 trials
• Hoffmann-La Roche5 trials
• Ottawa Heart Institute Research Corporation5 trials
• Novo Nordisk A/S4 trials
• Population Health Research Institute4 trials
• and 53 more

Running trials

• Recruiting

  A Research Study Investigating Denecimig (Mim8) in Adults With Acquired Haemophilia A

  NCT07830732· Phase 3· Novo Nordisk A/S· Source

  Contact: Novo Nordisk

• Recruiting

  A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis

  NCT07521007· Phase 2· Beijing Inno Medicine Co., Ltd.· Source

  Contact: John Graham

• Recruiting

  Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients

  NCT07695090· Phase 2· Qanatpharma AG· Source

  Contact: Research Coordinator

• Recruiting

  Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares

  NCT07245732· Phase 4· Sunnybrook Health Sciences Centre· Source

  Contact: Lauren King, MD, PhD, FRCPC

• Active, not recruiting

  Intravascular Neuro OCT Imaging System for Aneurysm Treatment Evaluation

  NCT07214220· Spryte Medical· Source

• Recruiting

  Integrated Suicide & Trauma Therapy for Suicide Risk

  NCT05613972· Unity Health Toronto· Source

  Contact: Molly Hyde, MSc, PhD (cand.)

• Active, not recruiting

  A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

  NCT07170150· Phase 3· Hoffmann-La Roche· Source

• Recruiting

  Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

  NCT07059962· Bodyport Inc.· Source

  Contact: Disha Sharma

• Recruiting

  EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

  NCT07064473· Phase 3· Boehringer Ingelheim· Source

  Contact: Boehringer Ingelheim

• Active, not recruiting

  P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk

  NCT06468033· Phase 3· PharmaEssentia· Source

• Recruiting

  Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

  NCT07177352· Phase 3· Hoffmann-La Roche· Source

• Recruiting

  A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

  NCT06979362· Phase 2· Novo Nordisk A/S· Source

  Contact: Novo Nordisk

• Recruiting

  Shorter and Safer Treatment Regimens for Latent TB

  NCT06498414· Phase 2/3· McGill University Health Centre/Research Institute of the McGill University Health Centre· Source

  Contact: Natasha Sabur, MD

• Recruiting

  ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

  NCT06902558· Phase 2· Calico Life Sciences LLC· Source

  Contact: Calico Clinical Trial Communication

• Recruiting

  A Study of Transcatheter Aortic Valve Replacement Case Selection and Valve Sizing Using the ABC Bicuspid Sizing Algorithm

  NCT06991517· World Health Research Inc.· Source

  Contact: Sarah Tawadros, MD

• Recruiting

  Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

  NCT06563895· Phase 3· Eidos Therapeutics, a BridgeBio company· Source

• Recruiting

  COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty

  NCT06809998· Phase 1/2· Unity Health Toronto· Source

  Contact: Amir Khoshbin, MD, FRCS (C)

• Recruiting

  Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment

  NCT06780917· Centre for Addiction and Mental Health· Source

  Contact: Lina Buelvas

• Not yet recruiting

  Implementation of Online Mindfulness-Based Stress Reduction Tailored for People with Multiple Sclerosis

  NCT06415552· Robert Simpson· Source

  Contact: Jillian Scandiffio

• Recruiting

  Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

  NCT06736574· Phase 3· Cytokinetics· Source

  Contact: Cytokinetics MD

• Active, not recruiting

  Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

  NCT06498960· CereVasc Inc· Source

• Active, not recruiting

  Evaluation of a Simple-Prep Controlled Embolic

  NCT06453642· Fluidx Medical Technology, Inc.· Source

• Recruiting

  Pericardiotomy in Cardiac Surgery

  NCT06486636· Population Health Research Institute· Source

  Contact: Dr. David Mazer

• Recruiting

  ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632

  NCT06320431· Phase 3· University of Calgary· Source

  Contact: Pawell Kostyrko

• Active, not recruiting

  EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

  NCT06531824· Phase 3· Boehringer Ingelheim· Source

• Recruiting

  Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial

  NCT05841056· Phase 3· Population Health Research Institute· Source

  Contact: Camila Mayorga Palacios

• Recruiting

  Fixed Duration vs Continuous Anti-CD38 Antibody Therapy Among Transplant Ineligible Older Adults With Newly-Diagnosed Multiple Myeloma

  NCT06182774· Phase 3· Canadian Cancer Trials Group· Source

  Contact: Martina Trinkaus

• Enrolling by invitation

  ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

  NCT05932615· Abbott Medical Devices· Source

• Recruiting

  The STOP-MED CTRCD Trial

  NCT06183437· Phase 4· Dinesh Thavendiranathan· Source

  Contact: Kim Connelly, MD

• Active, not recruiting

  Take-home Functional Electrical Stimulation for MDD

  NCT06261177· Unity Health Toronto· Source

• Active, not recruiting

  Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

  NCT05598333· Phase 2· AskBio Inc· Source

• Recruiting

  International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)

  NCT06174727· Montefiore Medical Center· Source

  Contact: Vitor Mendes Pereira, MD

• Active, not recruiting

  MS-DETECT: Early Detection of Multiple Sclerosis Progression With MSCopilot® Detect

  NCT05816122· Ad scientiam· Source

• Recruiting

  A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living With HIV

  NCT05495906· Phase 4· University of British Columbia· Source

  Contact: Klaudia Szczech, MSc

• Recruiting

  TOward a comPrehensive Supportive Care Intervention for Older Men With Metastatic Prostate Cancer

  NCT05582772· University Health Network, Toronto· Source

  Contact: Ronita Lee, MD

• Active, not recruiting

  Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD

  NCT05711940· Phase 3· COMPASS Pathways· Source

• Active, not recruiting

  Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

  NCT05478304· AtriCure, Inc.· Source

• Recruiting

  COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes

  NCT05633810· Phase 3· Montreal Heart Institute· Source

  Contact: Andrew Pinto, MD

• Active, not recruiting

  A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV

  NCT05481151· Phase 3· PharmaEssentia· Source

• Recruiting

  Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

  NCT05298124· Ottawa Heart Institute Research Corporation· Source

  Contact: Neil Fam, MD

• Enrolling by invitation

  Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

  NCT04451044· Philips Clinical & Medical Affairs Global· Source

• Recruiting

  Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

  NCT04634240· University of British Columbia· Source

  Contact: Neil Fam, MD

• Active, not recruiting

  A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

  NCT04544449· Phase 3· Hoffmann-La Roche· Source

• Recruiting

  Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

  NCT03573089· The University of Queensland· Source

  Contact: Ron Wald, Dr

• Active, not recruiting

  SyncAV Post-Market Trial

  NCT04100148· Abbott Medical Devices· Source

• Active, not recruiting

  A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis

  NCT04035005· Phase 3· Hoffmann-La Roche· Source

• Active, not recruiting

  A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B

  NCT03861273· Phase 3· Pfizer· Source

• Active, not recruiting

  Exploratory Study of the Edwards APTURE Transcatheter Shunt System (ALT-FLOW Canada)

  NCT04000607· Edwards Lifesciences· Source

• Active, not recruiting

  Reversal of Atrial Substrate to Prevent Atrial

  NCT03682991· Nova Scotia Health Authority· Source

• Active, not recruiting

  Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

  NCT03674307· University of British Columbia· Source

Showing 50 of 65.

Recruiting at the same time

How many trials recruit for the same indication here at once. A count, not a rating.

• Heart failure5 recruiting
• Aortic stenosis3 recruiting
• Chronic kidney disease3 recruiting
• Coronary artery disease3 recruiting
• Atrial fibrillation2 recruiting
• Depression2 recruiting
• High blood pressure2 recruiting
• Type 2 diabetes2 recruiting
• Amyloidosis1 recruiting
• Aortic aneurysm1 recruiting
• Brain aneurysm1 recruiting
• COPD1 recruiting
• Haemophilia1 recruiting
• HIV1 recruiting
• Multiple myeloma1 recruiting
• Multiple sclerosis1 recruiting
• Obesity1 recruiting
• Osteoarthritis1 recruiting
• Osteoporosis1 recruiting
• Polycystic kidney disease1 recruiting
• Prostate cancer1 recruiting
• Rheumatoid arthritis1 recruiting
• Stroke1 recruiting
• Tuberculosis1 recruiting

Closed trials

• Completed

  Incomplete Cervical SCI Without Instability

  NCT05653206· AO Foundation, AO Spine· Source

• Completed

  Musical Attention Control and Executive Function Training for Adults With MDD

  NCT05694156· Unity Health Toronto· Source

• Completed

  Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT

  NCT03825965· Phase 3· McMaster University· Source

• Completed

  A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)

  NCT05841030· Janssen Research & Development, LLC· Source

• Completed

  SMILE Trial - Imaging Sub-Study

  NCT05528718· Unity Health Toronto· Source

• Completed

  Personalized Smoking Cessation Infographic in COPD

  NCT04119934· Unity Health Toronto· Source

• Completed

  A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD

  NCT05113771· Phase 2· Denovo Biopharma LLC· Source

• Completed

  Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial

  NCT04957368· Phase 4· Unity Health Toronto· Source

• Completed

  A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation

  NCT05076149· Phase 3· Vertex Pharmaceuticals Incorporated· Source

• Completed

  Near Patient Study of the OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test in Oral Fluid and Fingerstick Whole Blood

  NCT04810559· Unity Health Toronto· Source

• Completed

  A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

  NCT04777409· Phase 3· Novo Nordisk A/S· Source

• Recruiting

  Nabilone for Agitation Blinded Intervention Trial

  NCT04516057· Phase 3· Sunnybrook Health Sciences Centre· Source

  Contact: NAB-IT Coordinating Centre

• Completed

  Nasal High Flow Therapy in Surgical Patients with Unrecognized Obstructive Sleep Apnea

  NCT03964376· University Health Network, Toronto· Source

• Recruiting

  Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

  NCT00843375· University of Michigan Rogel Cancer Center· Source

  Contact: Cancer AnswerLine

• Completed

  A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes

  NCT03914326· Phase 3· Novo Nordisk A/S· Source

• Completed

  (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

  NCT03580655· Phase 2· Blueprint Medicines Corporation· Source

• Completed

  A Study to Evaluate Prospective Efficacy and Safety Data of Current FIX Prophylaxis Replacement Therapy in Adult Hemophilia B Subjects (FIX:C≤2%) or Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Subjects (FVIII:C≤1%)

  NCT03587116· Phase 3· Pfizer· Source

• Completed

  Colchicine and Spironolactone in Patients with MI / SYNERGY Stent Registry

  NCT03048825· Phase 3· Population Health Research Institute· Source

• Completed

  PIONEER III Trial to Assess Safety and Efficacy of the BuMA Supreme™ Drug Coated Coronary Stent in Patients With Coronary Disease

  NCT03168776· Sino Medical Sciences Technology Inc.· Source

• Completed

  Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

  NCT03020303· Phase 3· Hamilton Health Sciences Corporation· Source

• Completed

  Antiarrhythmics or Ablation for Ventricular Tachycardia 2

  NCT02830360· Phase 4· John Sapp· Source

• Completed

  Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial

  NCT02168829· Phase 4· Ottawa Heart Institute Research Corporation· Source

• Completed

  SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System

  NCT02439775· Medtronic Vascular· Source

• Completed

  Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

  NCT01938248· Phase 4· Population Health Research Institute· Source

• Completed

  A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

  NCT02398656· Phase 3· University of Calgary· Source

• Terminated

  Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in AF

  NCT02387229· Phase 3· Montreal Heart Institute· Source

• Withdrawn

  Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry

  NCT04110912· Unity Health Toronto· Source

• Completed

  Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

  NCT02089217· Mayo Clinic· Source

• Terminated

  Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients

  NCT02085265· Phase 2· Sunnybrook Health Sciences Centre· Source

• Completed

  ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

  NCT02078427· Baxalta now part of Shire· Source

• Completed

  Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction

  NCT00673842· Phase 3· University of Calgary· Source

• Completed

  A Study of the Efficacy and Safety of Ocrelizumab in Patients With Relapsing-Remitting Multiple Sclerosis

  NCT00676715· Phase 2· Genentech, Inc.· Source