Depression trials in United States

In United States 272 Also abroad 666

272 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
Where
Birmingham, Philadelphia, Portland, Seattle, Tuscaloosa
Age
18 years to 75 years
People
240
Run by
VA Office of Research and Development
See details and how to joinNCT07226232
Phase 1/2Not yet taking people in United States
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
Where
Indianapolis
Age
18 years and over
People
50
Run by
Indiana University
See details and how to joinNCT07499583
No phaseTaking people
Neural Mechanisms of Real-world Emotions and Internalizing
Where
Coral Gables
Age
18 years to 35 years
People
144
Run by
University of Miami
See details and how to joinNCT07891624
Phase 3Taking people
A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
Where
Albuquerque, Austin, Bellaire, Charlotte, Draper, Edmond, Friendswood, Glen Oaks, Iowa City, Marrero, Miami Gardens, New Haven, Oceanside, O'Fallon, Oklahoma City, Orange, Orlando, Palm Bay, Philadelphia, Roanoke, San Jose, Stafford, Tampa, Wichita Falls
Age
18 years and over
People
550 worldwide
Run by
Neurocrine Biosciences
See details and how to joinNCT07196501 · EU 2025-520541-72-00
No phaseNot yet taking people in United States
Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms
Where
Oxford
Age
18 years to 30 years
People
330
Run by
Miami University
See details and how to joinNCT07889908
Phase 2/3Taking people
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
Where
Belmont, Sarasota, West Palm Beach
Age
18 years to 80 years
People
240
Run by
NeuroRx, Inc.
See details and how to joinNCT07227103
Phase 2Taking people
A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety
Where
Columbus
Age
21 years to 65 years
People
40
Run by
Ohio State University
See details and how to joinNCT06820723
No phaseTaking people
Transcranial Direct Current Stimulation for Depression
Where
Woodbridge
Age
22 years and over
People
25
Run by
Soterix Medical
See details and how to joinNCT07042217
Phase 2Taking people
Mindfulness-based Psilocybin Therapy for PTSD
Where
Columbus
Age
21 years to 65 years
People
30
Run by
Anthony P King
See details and how to joinNCT07104916
Phase 2Taking people
Neurobiology of Suicide
Where
Bethesda
Age
18 years to 70 years
People
325
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT02543983
No phaseTaking people
In-patient SCC TMS
Where
Los Angeles
Age
18 years to 65 years
People
30
Run by
University of California, Los Angeles
See details and how to joinNCT05645575
No phaseTaking people
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Where
Atlanta, Austin, Birmingham, Boston, Charleston, Chicago, Cleveland, Columbus, Dallas, Houston, Indianapolis, Los Angeles, Milwaukee, Minneapolis, New Brunswick, New York, Philadelphia, Rochester, Sacramento, Salt Lake City, St Louis, Tampa
Age
22 years to 70 years
People
100
Run by
Abbott Medical Devices
See details and how to joinNCT06423430
Phase 2Taking people
Intravenous Ketamine for Treatment-Resistant Depression
Where
Rochester
Age
18 years to 65 years
People
30
Run by
Mayo Clinic
See details and how to joinNCT06668571
Phase 2Not yet taking people in United States
The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
Where
Pittsburgh, St Louis
Age
60 years and over
People
300 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT07810738
No phaseNot yet taking people in United States
Augmented Depression Therapy (ADepT) Case Series
Where
Columbus
Age
18 years to 65 years
People
40
Run by
Ohio State University
See details and how to joinNCT07733310
No phaseNot yet taking people in United States
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
Where
Birmingham
Age
18 years to 85 years
People
25
Run by
University of Alabama at Birmingham
See details and how to joinNCT07863817
Phase 2Taking people
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
Where
Allentown, Bellevue, Bellflower, Boston, Chicago, Columbus, Costa Mesa, Decatur, DeSoto, Fort Worth, Hialeah, Lafayette, Little Rock, Media, New York, Orlando, Phoenix, Seattle, Skokie, Tampa
Age
18 years to 75 years
People
118
Run by
Draig Therapeutics Ltd
See details and how to joinNCT07610473
No phaseTaking people
Cortical rTMS as a Treatment for Depression
Where
Houston
Age
18 years to 64 years
People
50
Run by
Baylor College of Medicine
See details and how to joinNCT05487911
No phaseNot yet taking people in United States
Sensory Synchronized Imaging and Neuromodulation
Where
Palo Alto
Age
18 years and over
People
250
Run by
VA Office of Research and Development
See details and how to joinNCT06548113
No phaseTaking people
Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
Where
Pittsburgh
Age
18 years to 55 years
People
200
Run by
Marta Peciña, MD PhD
See details and how to joinNCT06976840
Phase 3Taking people
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
Where
Atlanta, Austin, Bellaire, Bellflower, Brooklyn, Cherry Hill, Chicago, Chino, Cincinnati, Dallas, Edmond, Glendale, Houston, Imperial, Jacksonville, Las Vegas, Los Angeles, Memphis, Miami, New York, Norcross, Oceanside, Oklahoma City, Pikesville, Portland, Redlands, San Antonio, San Diego, Sherman Oaks, Snellville, Springfield, Staten Island, The Bronx, Toms River, Tucson, Walnut Creek
Age
18 years to 65 years
People
508
Run by
Axsome Therapeutics, Inc.
See details and how to joinNCT07484217
No phaseNot yet taking people in United States
Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study
Where
Boston, Cleveland, San Francisco
Age
18 years and over
People
60
Run by
University of California, San Francisco
See details and how to joinNCT07596914
No phaseTaking people
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
Where
Boston
Age
18 years to 65 years
People
80
Run by
Massachusetts General Hospital
See details and how to joinNCT05523817
Phase 1Taking people
Meditative Neurofeedback for Depression
Where
La Jolla
Age
18 years and over
People
60
Run by
University of California, San Diego
See details and how to joinNCT06675240
No phaseNot yet taking people in United States
Transcendental Meditation Intervention to Reduce Burnout and Enhance Resilience Among NewYork-Presbyterian Hospital and Weill Cornell Medicine Employees and Residents
Where
New York
Age
18 years and over
People
15
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07868783